Case Report: A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi in Vietnam

Abstract

Background

Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissues caused by different melanized fungi. The disease occurs worldwide, particularly in tropical and subtropical regions but not reported in Vietnam.

Case Summary

A 47-year-old women was admitted to hospital 103, Hanoi, Vietnam, with a 10-year lasting lesion on backside of her right shank. Diagnosis of chromoblastomycosis was made after discovery of a muriform cell in histopathological examination. A black, slow-growth fungus was isolated and identified as Fonsecaea pedrosoi after molecular analysis. After 1-month treatment with itraconazole, the lesion has significant improvement.

Conclusion

This is the first case of chromoblastomycosis caused by Fonsecaea pedrosoi reported in Vietnam.

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Abbreviations

CBM:

Chromoblastomycosis, chromomycosis

KOH:

Potassium hydroxide

DNA:

Deoxyribonucleic acid

dNTP:

Deoxynucleotide

PCR:

Polymerase chain reaction

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Acknowledgements

The authors are grateful to Mr. Robert Mayrhofer and Ms. Linh Khanh Le for revising the English text.

Authors’ Contributions

KLN and NAD conducted the study, as well as morphological and molecular analyses of the isolated strain. MHP collected clinical data. TTV made the histopathological examination. TAL designed the study and created the final draft of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Tran-Anh Le.

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The authors declare that they have no competing interests.

Availability of Data and Material

The sequence generated and analyzed during the current study is available in the GenBank under the code MF MF173064.

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The authors agreed to publish this article in Mycopathologia.

Ethics Approval and Consent to Participate

Written informed consent was obtained from the patient for the publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.

Additional information

Handling Editor: Yuping Ran.

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Le, TA., Nguyen, KL., Pham, MH. et al. Case Report: A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi in Vietnam. Mycopathologia 184, 115–119 (2019). https://doi.org/10.1007/s11046-018-0284-3

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Keywords

  • Case report
  • Fonsecaea pedrosoi
  • Chromoblastomycosis
  • Human
  • Vietnam
  • Molecular analysis