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Study on the Clinical Features and Prognosis of Penicilliosis marneffei Without Human Immunodeficiency Virus Infection

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To improve the diagnosis and treatment of Penicilliosis marneffei without human immunodeficiency virus infection.


Analyze and review the clinical features, diagnosis and treatment of six cases of P. marneffei without human immunodeficiency virus infection at The First Affiliated Hospital of Fujian Medical University.


Two cases were diagnosed in the ENT Department, three cases in the respiratory department and one case in the dermatological department. Penicillium marneffei infection was confirmed by sputum culture, blood culture and tissue biopsy. After definite diagnosis, one refused further treatment, and others showed significant improvement.


Penicilliosis marneffei is insidious onset and easy to be escaped and misdiagnosed. To achieve early diagnosis and appropriate treatment, doubtful cases should be alerted for the diagnoses as P. marneffei.

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Authors thank professor Lin Qi-chang, Department of Respiration, the First Affiliated Hospital of Fujian Medical University, for his kind of offering the cases of respiratory department. We also thank our colleagues of clinical laboratory for their assistance of fungal identification.

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Correspondence to Sheng-nan Ye.

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The research was compliance with ethical standards, and all the patients involved were informed consent.

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Wang, Yg., Cheng, Jm., Ding, Hb. et al. Study on the Clinical Features and Prognosis of Penicilliosis marneffei Without Human Immunodeficiency Virus Infection. Mycopathologia 183, 551–558 (2018).

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