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Mycopathologia

, Volume 183, Issue 3, pp 573–577 | Cite as

Donor Derived Candida stellimalicola in a Clinical Specimen: Preservation Fluid Contamination During Pancreas Procurement

  • Damien Dupont
  • Antoine Huguenin
  • Elodie Tisserand
  • Véronique Reiter
  • Emmanuel Morelon
  • Lionel Badet
  • Isabelle Villena
  • Martine Wallon
  • Dominique Toubas
Short Communication
  • 96 Downloads

Abstract

We report here a case of possible donor-derived Candida stellimalicola infection after pancreas transplantation. Candida stellimalicola, an environmental non-filamentous yeast, was isolated from both the peritoneal fluid of the graft donor and the preservation fluid of the transplanted pancreas. Interestingly, this strain exhibited high minimum inhibitory concentrations to azoles. These results justified the use of echinocandins as therapy instead of fluconazole. This switch permitted a favorable outcome. To our knowledge, this is the first report of C. stellimalicola from clinical samples and therefore the first reported case of a possible human infection. This case report highlights the need for standardized microbiological procedures in solid organ transplant settings. Moreover, it underlines the importance of using molecular identification technique when routine techniques do not allow successful identification of the pathogen. It is of utmost importance to determine sensitivity profile, even in the absence of species-level identification, because resistance to fluconazole is not uncommon, especially in emergent species.

Keywords

Candida stellimalicola Infection Transplant recipient Azole resistance Emerging pathogen 

Notes

Acknowledgements

The authors would like to thank Dr A. L. Bienvenu, M. Fernandes and A. Gaudin. They also thank the Biofidal staff for sequencing.

Compliance with Ethical Standards

Conflict of interest

The authors have no relevant conflicts of interest.

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Damien Dupont
    • 1
    • 2
  • Antoine Huguenin
    • 3
  • Elodie Tisserand
    • 4
  • Véronique Reiter
    • 5
  • Emmanuel Morelon
    • 6
  • Lionel Badet
    • 7
  • Isabelle Villena
    • 3
    • 8
  • Martine Wallon
    • 1
    • 2
  • Dominique Toubas
    • 3
    • 9
  1. 1.Institut des Agents Infectieux, Parasitologie MycologieHôpital de la Croix-Rousse, Hospices Civils de LyonLyonFrance
  2. 2.Integrative Physiology of the Brain Arousal Systems, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de MédecineUniversité Claude Bernard Lyon 1LyonFrance
  3. 3.Laboratoire de Parasitologie Mycologie, CHU de ReimsUniversité Reims Champagne Ardenne, Hôpital Maison BlancheReimsFrance
  4. 4.Pediatric Intensive Care Unit, CHU de ReimsUniversité Reims Champagne Ardenne, Hôpital Maison BlancheReimsFrance
  5. 5.PMO, CHU de ReimsUniversité Reims Champagne Ardenne, Hôpital Maison BlancheReimsFrance
  6. 6.Service de Transplantation, Néphrologie et ImmunologieHôpital Edouard Herriot, Hospices Civils de LyonLyonFrance
  7. 7.Service d’Urologie et TransplantationHôpital Edouard Herriot, Hospices Civils de LyonLyonFrance
  8. 8.Laboratoire de Parasitologie-Mycologie, EA3800, SFR Cap-Santé, UFR de MédecineUniversité de Reims Champagne-ArdenneReimsFrance
  9. 9.MéDIAN-Biophotonique et Technologies pour la Santé, CNRS UMR 7369 MEDyC, UFR de Médecine, SFR CAP SantéUniversité de Reims Champagne-ArdenneReimsFrance

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