Abstract
Paracoccidioidomycosis is an endemic mycosis caused by Paracoccidioides species limited to Latin America arising with the chronic form in 90% of cases. The capacity of microorganisms to form biofilms is considered of great importance medical since can contribute to the persistence and to the chronic state of the diseases. The ability of Paracoccidioides to form biofilm has been demonstrated in vitro. In our study, for the first time we have observed this capability in vivo on a vascular prosthesis using scanning electron microscope showing a dense network of Paracoccidioides yeasts covered by an extracellular matrix.
References
Teixeira MDM, Theodoro RC, De Oliveira FFM, Machado GC, Hahn RC, Bagagli E, et al. Paracoccidioides lutzii sp. nov.: biological and clinical implications. Med Mycol. 2014;52:19–28.
Negroni R. Paracoccidioidomycosis (South American blastomycosis, Lutz’s mycosis). Int J Dermatol. 1993;32:847–59.
Rüssel M, Melo VL, Paniagua BA, Tracogna F. Paracoccidioidomicosis: presentación inusual. Arch Argent Dermatol. 2016;66:12–4.
Sardi JC, Pitangui NS, Voltan AR, Braz JD, Machado MP, Fusco Almeida AM, et al. In vitro Paracoccidioides brasiliensis biofilm and gene expression of adhesins and hydrolytic enzymes. Virulence. 2015;6:642–51.
Pitangui NS, Sardi JC, Silva JF, Benaducci T, Moraes da Silva RA, Rodríguez-Arellanes G, et al. Adhesion of Histoplasma capsulatum to pneumocytes and biofilm formation on an abiotic surface. Biofouling. 2012;28:711–8.
Angiolella L, Stringaro A, De Bernardis F, Posteraro B, Bonito M, Toccacieli L, et al. Increase of virulence and its phenotypic traits in drug-resistant strains of Candida albicans. Antimicrob Agents Chemother. 2008;52:927–36.
Tronchin G, Marc Pihet M, Lopes-Bezerra L, Bouchara J. Adherence mechanisms in human pathogenic fungi. Med Mycol. 2008;46:749–72.
Benaducci T, Sardi JDC, Lourencetti NM, Scorzoni L, Gullo FP, Rossi SA, et al. Virulence of Cryptococcus sp. biofilms in vitro and in vivo using Galleria mellonella as an alternative model. Front Microbiol. 2016;7:290–1.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Cattana, M.E., Tracogna, M.F., Marques, I. et al. In Vivo Paracoccidioides sp. Biofilm on Vascular Prosthesis. Mycopathologia 182, 747–749 (2017). https://doi.org/10.1007/s11046-017-0126-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11046-017-0126-8