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Fungaemia Caused by Fusarium proliferatum in a Patient Without Definite Immunodeficiency

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Abstract

Recent literature has shown the growing importance of opportunistic fungal infections due to Fusarium spp. However, disseminated fusariosis remains rare in patients without neutropenia. We report a case of fungaemia in a 78-year-old French woman without definite immunodeficiency. Fusarium proliferatum grew from both central and peripheral blood cultures. Fever was the only clinical sign of the infection. An appropriate antifungal therapy with voriconazole led to the recovery of the patient. An environmental investigation was undertaken but failed to find a reservoir of Fusarium spores. A contaminated central venous catheter might have been the source of fungaemia.

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Authors and Affiliations

  1. Infection Control Department and Environmental Analysis Laboratory, Service Hygiène, Epidémiologie et Prévention, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, 5 place d’Arsonval, 69437, Lyon Cedex 03, France

    Cédric Dananché, Pierre Cassier, Michel Perraud, Marie-Christine Nicolle & Philippe Vanhems

  2. Centre International de Recherche en Infectiologie (CIRI), INSERM U1111 - CNRS UMR 5308, Université Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France

    Pierre Cassier

  3. Parasitology and Mycology Laboratory, Plateau Technique de Biologie, Centre Hospitalier Universitaire, Dijon, France

    Marc Sautour

  4. Institut National de la Recherche Agronomique (INRA), UMR 1347 Agroécologie, Dijon, France

    Nadine Gautheron

  5. Department of Orthopaedic Surgery, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, Lyon, France

    Julien Wegrzyn

  6. INSERM UMR 1033, Université Lyon 1, Lyon, France

    Julien Wegrzyn

  7. Medical Mycology Department, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France

    Anne-Lise Bienvenu

  8. Infectious Diseases Unit, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France

    André Boibieux

  9. Epidemiology and Public Health Group, Université Lyon 1, Lyon, France

    Philippe Vanhems

Authors
  1. Cédric Dananché
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  2. Pierre Cassier
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  3. Marc Sautour
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  4. Nadine Gautheron
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  5. Julien Wegrzyn
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  6. Michel Perraud
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  7. Anne-Lise Bienvenu
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  8. Marie-Christine Nicolle
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  9. André Boibieux
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  10. Philippe Vanhems
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Correspondence to Cédric Dananché.

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Dananché, C., Cassier, P., Sautour, M. et al. Fungaemia Caused by Fusarium proliferatum in a Patient Without Definite Immunodeficiency. Mycopathologia 179, 135–140 (2015). https://doi.org/10.1007/s11046-014-9817-6

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  • DOI: https://doi.org/10.1007/s11046-014-9817-6

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