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Chronic Paracoccidioidomycosis of the Intestine as Single Organ Involvement Points to an Alternative Pathogenesis of the Mycosis

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Abstract

Current knowledge on the natural history of paracoccidioidomycosis states that the chronic form of the disease results from reactivation of quiescent foci established years or decades before during the primary lung infection. Once reactivated, the fungi can disseminate to virtually any organ or system. We present herein two chronic paracoccidioidomycosis patients with a single organ involvement that points to an alternative pathogenesis of the mycosis. These patients suggest that the chronic form may also arise from reactivation of foci not confined to the lungs, due to the early dissemination of yeast cells during the primary infection.

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References

  1. Queiroz-Telles F, Escuissato DL. Pulmonary paracoccidioidomycosis. Semin Respir Crit Care Med. 2011;32:764–74.

    Article  PubMed  Google Scholar 

  2. Franco M, Montenegro MR, Mendes RP, Marques SA, Dillon NL, Mota NG. Paracoccidioidomycosis: a recently proposed classification of its clinical forms. Rev Soc Bras Med Trop. 1987;20:129–323.

    Article  PubMed  CAS  Google Scholar 

  3. Cunha MAR, Pereira AR, Gouveia OF, et al. Contribuição ao estudo radiológico da blastomicose sul-americana no aparelho digestivo. O Hospital. 1966;69:195–200.

    Google Scholar 

  4. Fonseca LC, Mignone C. Paracoccidioidomycosis of the small intestine. Radiologic and anatomo clinical aspects of 125 cases. Revista do Hospital das Clinicas da Faculdade de Medicina de Sao Paulo. 1976;31:199–207.

    CAS  Google Scholar 

  5. Goldani LZ. Gastrointestinal paracoccidioidomycosis: an overview. J Clin Gastroenterol. 2011;45:87–91.

    Article  PubMed  Google Scholar 

  6. Bellissimo-Rodrigues F, Machado AA, Martinez R. Paracoccidioidomycosis epidemiological features of a 1,000-cases series from a hyperendemic area on the southeast of Brazil. Am J Trop Med Hyg. 2011;85:546–50.

    Article  PubMed  Google Scholar 

  7. Benard G. An overview of the immunopathology of human paracoccidioidomycosis. Mycopathologia. 2008;165:209–21.

    Article  PubMed  CAS  Google Scholar 

  8. Costa AN, Benard G, Albuquerque ALP, et al. The lung in paracoccidioidomycosis: new insights into old problems. Clinics. 2013;68:1–8.

    Google Scholar 

  9. Shankar J, Restrepo A, Clemons KV, Stevens DA. Hormones and the resistance of women to paracoccidioidomycosis. Clin Microbiol Rev. 2011;24:296–313.

    Article  PubMed  CAS  Google Scholar 

  10. Opie E, Aronson J. Tubercle bacilli in latent tuberculous lesions and in lung tissue without tuberculous lesions. Arch Pathol Lab Med. 1927;4:1–21.

    Google Scholar 

  11. Hernandez-Pando R, Jeyanathan M, Mengistu G, et al. Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection. Lancet. 2000;356:2133–8.

    Article  Google Scholar 

  12. Barrios-Payan J, Saqui-Salces M, Jeyanathan M, et al. Extrapulmonary locations of mycobacterium tuberculosis DNA during latent infection. J Infect Dis. 2012;206:1194–205.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Medical Investigation Units 56 and 53, Clinics Hospital and Laboratory of Medical Mycology, Tropical Medicine Institute, University of São Paulo Medical School, Av Dr. Eneas de Carvalho Aguiar 470, São Paulo, CEP 05403-000, Brazil

    G. Benard

  2. Pulmonary Division, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil

    A. N. Costa

  3. Mycosis Outpatient Service, Division of Infectious Diseases, Medical School, Clinics Hospital, University of São Paulo, São Paulo, Brazil

    A. P. S. Leopércio, A. Kono & M. A. Shikanai-Yasuda

  4. Adolfo Lutz Institute, São Paulo, Brazil

    A. P. Vicentini

  5. Laboratory of Medical Investigation Unit 48, Tropical Medicine Institute, University of São Paulo, São Paulo, Brazil

    M. A. Shikanai-Yasuda

Authors
  1. G. Benard
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  2. A. N. Costa
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  3. A. P. S. Leopércio
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  4. A. P. Vicentini
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  5. A. Kono
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  6. M. A. Shikanai-Yasuda
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Correspondence to G. Benard.

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Benard, G., Costa, A.N., Leopércio, A.P.S. et al. Chronic Paracoccidioidomycosis of the Intestine as Single Organ Involvement Points to an Alternative Pathogenesis of the Mycosis. Mycopathologia 176, 353–357 (2013). https://doi.org/10.1007/s11046-013-9699-z

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  • DOI: https://doi.org/10.1007/s11046-013-9699-z

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