, Volume 175, Issue 1–2, pp 99–106 | Cite as

Disseminated Zygomycosis Caused by Cunninghamella bertholletiae in Patient with Hematological Malignancy and Review of Published Case Reports

  • Tsung-Ting Hsieh
  • Hsiang-Kuang Tseng
  • Pei-Lun SunEmail author
  • Yu-Hung Wu
  • Gon-Shen Chen


Cunninghamella bertholletiae is an unusual opportunistic pathogen belonging to the class Zygomycetes, order Mucorales, and the family Cunninghamellaceae. It has been identified with increased frequency in immunocompromised patients, especially those with hematological malignancy. Clinical infection by this fungus is almost always devastating. We report a fatal case of disseminated zygomycosis due to Cunninghamella bertholletiae in an acute myeloid leukemia patient without chemotherapy. We also reviewed the cases of Cunninghamella bertholletiae infection reported in these 20 years. These cases highlight the high mortality rate and rapid progression associated with this opportunistic fungal infection in immunocompromised patients.


Acute myeloid leukemia Disseminated Zygomycosis Cunninghamella bertholletiae 


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Tsung-Ting Hsieh
    • 1
  • Hsiang-Kuang Tseng
    • 2
    • 3
    • 4
  • Pei-Lun Sun
    • 1
    • 5
    Email author
  • Yu-Hung Wu
    • 1
  • Gon-Shen Chen
    • 6
  1. 1.Department of DermatologyMackay Memorial HospitalTaipeiTaiwan
  2. 2.Division of Infectious Disease, Department of Internal MedicineMackay Memorial HospitalTaipeiTaiwan
  3. 3.Institute of Clinical MedicineNational Yang-Ming UniversityTaipeiTaiwan
  4. 4.Department of MedicineMackay Medical CollegeNew TaipeiTaiwan
  5. 5.Institute of Ecology and Evolutionary BiologyNational Taiwan UniversityTaipeiTaiwan
  6. 6.Division of Hematology, Department of Internal MedicineMackay Memorial HospitalTaipeiTaiwan

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