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Mycopathologia

, Volume 175, Issue 1–2, pp 129–134 | Cite as

Micafungin for Candida Albicans Pacemaker-Associated Endocarditis: A Case Report and Review of the Literature

  • Carlo Tascini
  • Maria Grazia Bongiorni
  • Enrico TagliaferriEmail author
  • Antonello Di Paolo
  • Sarah Flammini
  • Ezio Soldati
  • Alessandro Leonildi
  • Andrea Di Cori
  • Francesco Menichetti
Article

Abstract

We report on the treatment with micafungin of a pacemaker-associated endocarditis due to Candida albicans. Antifungal therapy was able to reduce vegetation size from 5 to 1 cm making possible the transvenous removal of the device without a high risk of pulmonary embolism. Noteworthy, a high micafungin concentration was documented into the lead vegetation (10 μg/g of vegetation tissue) and this may have contributed to the striking size reduction of vegetation.

Keywords

Micafungin Candida Endocarditis Pacemaker 

Notes

Acknowledgments

The authors wish to thank the nurse staff and technicians at the Santa Chiara University Hospital, Pisa.

Conflict of interest

In the past 2 years, Dr Carlo Tascini has been paid for lectures on behalf of Pfizer, Novartis, Merck and Astellas.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Carlo Tascini
    • 1
  • Maria Grazia Bongiorni
    • 2
  • Enrico Tagliaferri
    • 1
    • 4
    Email author
  • Antonello Di Paolo
    • 3
  • Sarah Flammini
    • 1
  • Ezio Soldati
    • 2
  • Alessandro Leonildi
    • 1
  • Andrea Di Cori
    • 2
  • Francesco Menichetti
    • 1
  1. 1.U.O. Malattie InfettiveAzienda Ospedaliera Universitaria PisanaPisaItaly
  2. 2.U.O. Cardiologia IIAzienda Ospedaliera Universitaria PisanaPisaItaly
  3. 3.Divisione di Farmacologia e ChemioterapiaUniversità di PisaPisaItaly
  4. 4.U.O. Malattie InfettiveNuovo Santa Chiara HospitalPisaItaly

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