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Multiple Fungal Brain Abscesses in a Child with Acute Lymphoblastic Leukemia

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Abstract

Fungal infection is a severe problem in children suffering from cancer. We report a case of a four-year-old girl who was diagnosed with acute lymphoblastic leukemia and multiple Aspergillus niger abscesses at the induction phase of the treatment. She was treated with granulocyte transfusions, liposomal amphotericin B with a combination of voriconazole for four months, followed by oral variconazole alone for 17 months. She was successfully treated with this combination without any sequel, and the planned chemotherapy was also completed. Our experience revealed that antifungal treatment including intravenous amphotericin B and variconazole augmented by granulocyte transfusion is an alternative option for the management of this catastrophic complication.

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Authors and Affiliations

  1. Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Erciyes University, 38039, Talas, Kayseri, Turkey

    Turkan Patiroglu, Ekrem Unal, Musa Karakukcu & Mehmet Akif Ozdemir

  2. Department of Neurosurgery, Faculty of Medicine, Erciyes University, Kayseri, Turkey

    Bülent Tucer

  3. Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

    Ali Yikilmaz

  4. Department of Pathology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

    Kemal Deniz

Authors
  1. Turkan Patiroglu
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  2. Ekrem Unal
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  3. Musa Karakukcu
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  4. Mehmet Akif Ozdemir
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  5. Bülent Tucer
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  6. Ali Yikilmaz
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  7. Kemal Deniz
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Correspondence to Ekrem Unal.

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Patiroglu, T., Unal, E., Karakukcu, M. et al. Multiple Fungal Brain Abscesses in a Child with Acute Lymphoblastic Leukemia. Mycopathologia 174, 505–509 (2012). https://doi.org/10.1007/s11046-012-9563-6

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  • DOI: https://doi.org/10.1007/s11046-012-9563-6

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