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Response to Oxidative Stress in Eight Pathogenic Yeast Species of the Genus Candida

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Abstract

In the course of an infection, the formation of reactive oxygen species by phagocytes and the antioxidant defense mechanisms of microorganisms play a crucial role in pathogenesis. In this study, isolates representing 8 pathogenic Candida species—Candida albicans, Candida dubliniensis, Candida famata, Candida glabrata, Candida guilliermondii, Candida krusei, Candida parapsilosis and Candida tropicalis—were compared with regard to their resistance to oxidative stress in vitro. We evaluated degree of resistance, induction of oxidative damage, capacity to adapt, and induction of antioxidant enzymes. The species showed variable sensitivity to oxidative attack. C. albicans, C. glabrata, and C. krusei were more resistant to oxidative stress under the conditions tested; C. parapsilosis and C. tropicalis presented medium resistance; and C. dubliniensis, C. famata, and C. guilliermondii were more sensitive. The overall greater resistance to oxidative stress of C. albicans and C. glabrata may provide an advantage to these species, which are the major causative agents of candidiasis.

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Acknowledgments

The authors thank Patrícia Valente for reading of the manuscript, M. H. Vainstein, T. I. E. Svidzinsky, S. H. Alves, and the Instituto Nacional de Controle de Qualidade em Saúde - INCQS for kindly providing strains.

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Authors and Affiliations

  1. Programa de Pós-Graduação em Biologia Celular e Molecular (PPGBCM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

    Maxwel Adriano Abegg, Paulo Vinicius Gil Alabarse, Fernanda Schäfer Hackenhaar & Mara Silveira Benfato

  2. Universidade Paranaense (UNIPAR), Toledo, PR, Brazil

    Maxwel Adriano Abegg, Anderson Casanova & Jaqueline Hoscheid

  3. Departamento de Biofísica (IBIO), Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9500 prédio 43431, Porto Alegre, RS, 91501-970, Brazil

    Paulo Vinicius Gil Alabarse, Tiago Boeira Salomon, Fernanda Schäfer Hackenhaar, Tássia Machado Medeiros & Mara Silveira Benfato

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  1. Maxwel Adriano Abegg
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Correspondence to Mara Silveira Benfato.

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Abegg, M.A., Alabarse, P.V.G., Casanova, A. et al. Response to Oxidative Stress in Eight Pathogenic Yeast Species of the Genus Candida . Mycopathologia 170, 11–20 (2010). https://doi.org/10.1007/s11046-010-9294-5

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  • DOI: https://doi.org/10.1007/s11046-010-9294-5

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