Mycopathologia

, 166:267 | Cite as

Pathogenesis of Dermatophytosis

  • Sandy Vermout
  • Jérémy Tabart
  • Aline Baldo
  • Anne Mathy
  • Bertrand Losson
  • Bernard Mignon
Article

Abstract

Despite the superficial localization of most dermatophytosis, host-fungus relationship in these infections is complex and still poorly elucidated. Though many efforts have been accomplished to characterize secreted dermatophytic proteases at the molecular level, only punctual insights have been afforded into other aspects of the pathogenesis of dermatophytosis, such as fungal adhesion, regulation of gene expression during the infection process, and immunomodulation by fungal factors. However, new genetic tools were recently developed, allowing a more rapid and high-throughput functional investigation of dermatophyte genes and the identification of new putative virulence factors. In addition, sophisticated in vitro infection models are now used and will open the way to a more comprehensive view of the interactions between these fungi and host epidermal cells, especially keratinocytes.

Keywords

Dermatophytes Pathogenesis Trichophyton Microsporum 

Abbreviations

DTH

Delayed-type hypersensitivity

IH

Immediate hypersensitivity

Sub

Subtilisin

Mep

Metalloprotease

DppIV

Dipeptidyl-peptidase IV

TRM

Trichophyton rubrum mannans

RFE

Reconstructed feline epidermis

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Sandy Vermout
    • 1
  • Jérémy Tabart
    • 1
  • Aline Baldo
    • 1
  • Anne Mathy
    • 1
  • Bertrand Losson
    • 1
  • Bernard Mignon
    • 1
  1. 1.Department of Infectious & Parasitic Diseases, Parasitology, Faculty of Veterinary MedicineUniversity of LiègeLiègeBelgium

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