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Mycotoxins in Mexico: Epidemiology, management, and control strategies

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Abstract

Mycotoxin-producing molds species are extremely common. Many of them provoke serious diseases in humans and animals. These toxins occur, with varying severity, in agricultural products. Since Mexico is a big crops producer, the importance of the presence of these toxins is high. Currently, the Mexican regulation establishes limits only for aflatoxins in cereals and cereal products. No limits are set for other mycotoxins. Epidemiological data although limited, has shown that an important number of samples contain mycotoxin limits above those established abroad. Several strategies for reducing contamination have been conducted in the country such as development of hybrid corn, control of insect population, use of natural products, and modification of nixtamalization and extraction procedures. Although significant research on this field has been conducted, there is still a great need for information to determine the incidence of mycotoxins in Mexican products.

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References

  1. H Gourama L Bullerman (1995) ArticleTitleAntimycotic and antiaflatoxigenic effect of lactic acid bacteria- a review J Food Prot 57 1275–1280

    Google Scholar 

  2. N Gqaleni JE Smith J Lancey (1996) ArticleTitleCo-production of aflatoxin and Cyclopiazonic acid in isolates of Aspergillus flavus Food Addit Contam 13 677–685 Occurrence Handle8871125 Occurrence Handle1:CAS:528:DyaK28Xlt1ansLg%3D

    PubMed  CAS  Google Scholar 

  3. D Bhatnagar S Garcia (2001) Aspergillus RG Labbé S Garcia (Eds) Guide to Foodborne Pathogens John Wiley and Sons New York 35–49

    Google Scholar 

  4. Vardon PJ. Micotoxins: risks in plant, animal and human systems, potential economic costs of micotoxins in the United States. Coast Task Force, 2003: 136–142. Report No 139

  5. J Plasencia (2004) ArticleTitleAflatoxins in maize: a mexican perspective J Toxicol 23 155–177 Occurrence Handle1:CAS:528:DC%2BD2cXnt1Gks7k%3D

    CAS  Google Scholar 

  6. LW Rooney SO Serna-Saldívar (2003) Food uses of whole corn and dry-milled fractions PJ White LA Johnson (Eds) Corn Chemistry and Technology American Association for Cereal Chemists St. Paul 399–429

    Google Scholar 

  7. Secretaría de Salud. Norma Oficial Mexicana NOM-188-SSA1–2002, Productos y Servicios: Control de aflatoxinas en cereales para consumo humano y animal, especificaciones sanitarias. Diario Oficial de la Federación. 2002: 11 de Marzo de 1999

  8. Secretaría de Salud. Norma Oficial Mexicana NOM-187-SSA1/SCFI-2002, Productos y Servicios: Masa, tortillas, tostadas y harinas preparadas para su elaboración y establecimiento donde se procesan. Especificaciones sanitarias. Información comercial, métodos de prueba. Diario Oficial de la Federación. 2003: 11 de Marzo de 1999

  9. M Carvajal A Bolaños F Rojo I Méndez (2003) ArticleTitleAflatoxin M1 in pasteurized milk with different fat content in Mexico J Food Prot 66 1885–1892 Occurrence Handle14572228 Occurrence Handle1:CAS:528:DC%2BD3sXoslais74%3D

    PubMed  CAS  Google Scholar 

  10. JD Figueroa (1999) ArticleTitleLa tortilla vitaminada Avance y Perspectiva 18 149–158

    Google Scholar 

  11. R Martinez-Flores G García-Aguirre (2003) ArticleTitleInspección de aflatoxinas en maíz cultivado, almacenado y transportado en el estado de Tamaulipas, Mexico en 1988 Anales Instituto de Biología, UNAM, serie Botánica 74 313–321

    Google Scholar 

  12. M Carvajal G Arroyo (1997) ArticleTitleManagement of aflatoxin contaminated maize in Tamaulipas, Mexico J Agric Food Chem 22 327–350

    Google Scholar 

  13. E Torres Espinoza K Acuña Askar L Naccha Torres R Montoya Olvera JP Castellon Santa Ana (1995) ArticleTitleQuantification of aflatoxins in corn distributed in the city of Monterrey, Mexico Food Add Contam 12 383–386

    Google Scholar 

  14. Ochoa MA, Torres ChP, Moreno IG, Yépiz GS, Alvarez ChR, Marroquin JA, Tequida MM, Silveira GM. Incidencia de Aflatoxina B1 y Zearalenona en trigo y maíz almacenado en el estado de Sonora. Rev. Cien. Alim. 1989; 1: 16–20

  15. Ledesma Osuna AI, Campas Baypoli ON,Torres PI, Ramirez-Wong B. Presence of aflatoxin in alkali treated corn products consumed in Sonora Mexico. Proceedings of Modulation of Chemical Toxicity and Risk Assessment Conference. University of Arizona, Tucson AZ, 1996: 9–12 June. http://jeeves.pharmacy.arizona.edu/conf/sponsors.html

  16. JA Méndez-Albores G Arámbula-Villa RE Preciado-Ortiz M Moreno-Martínez (2004) ArticleTitleAflatoxins in pozol, a nixtamalized, maize-based food Int. J. Food Micro. 94 211–215 Occurrence Handle10.1016/j.ijfoodmicro.2004.02.009 Occurrence Handle1:CAS:528:DC%2BD2cXkvVCrtb8%3D

    Article  CAS  Google Scholar 

  17. M Sharma C Márquez (2001) ArticleTitleDetermination of aflatoxins in domestic pet foods (dog and cat) using immunoaffinity column and HPLC Ann. Feed Sci. Technol. 93 109–114 Occurrence Handle1:CAS:528:DC%2BD3MXms12gsbY%3D Occurrence Handle10.1016/S0377-8401(01)00274-7

    Article  CAS  Google Scholar 

  18. MO Cortes-Rocha WR Ramirez-Astudillo RI Sánchez-Mariñez EC Rosas-Burgos FJ Wong-Corral J Borboa-Flores LG Castillón-Campaña M Tequida-Meneses (2003) ArticleTitleFumonisins and fungal species in corn from Sonora Mexico Bull. Environ. Contam. Toxicol. 70 668–673 Occurrence Handle10.1007/s00128-003-0036-y Occurrence Handle1:CAS:528:DC%2BD3sXjt1aks7w%3D

    Article  CAS  Google Scholar 

  19. MR Rosiles J Bautista VO Fuentes F Ross (1998) ArticleTitleAn outbreak of equine leukoencephalomalacia at Oaxaca Mexico, associated with fumonisin B1 Zentralbl. Veterninarmed A 45 299–302 Occurrence Handle1:CAS:528:DyaK1cXltV2nsrc%3D

    CAS  Google Scholar 

  20. VL Stevens J Tang (1997) ArticleTitleFumonisin B1-induced sphyngolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinositol-anchored folate receptor J Biol Chem 272 18020–18025 Occurrence Handle9218430 Occurrence Handle1:CAS:528:DyaK2sXkslKmsro%3D Occurrence Handle10.1074/jbc.272.29.18020

    Article  PubMed  CAS  Google Scholar 

  21. WFO Marasas RL Riley KA Hendricks VL Stevens TW Sadler J Gelineau-van Waes SA Missmer J Cabrera O Torres WCA Gelderblom J Allegood C Martinez J Maddox JD Miller L Starr MC Sullards AW Roman KA Voss E Wang AH Merril (2004) ArticleTitleFumonisins disrupt sphingolipid metabolism, folate transport and neural tube development in embryo culture and in vivo: A potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize J. Nutr. 134 711–716 Occurrence Handle15051815 Occurrence Handle1:CAS:528:DC%2BD2cXjtFWmtro%3D

    PubMed  CAS  Google Scholar 

  22. ML Robledo S Marín AJ Ramos (2001) ArticleTitleContaminación natural con micotoxinas en maíz forrajero y granos de café verde en el Estado de Nayarit (Mexico) Rev. Iberam. Micol 18 141–144

    Google Scholar 

  23. JW Bennett M Klich (2003) ArticleTitleMycotoxins Clin. Microbiol. Rev. 16 497–516 Occurrence Handle12857779 Occurrence Handle1:CAS:528:DC%2BD3sXmsV2qtL4%3D Occurrence Handle10.1128/CMR.16.3.497-516.2003

    Article  PubMed  CAS  Google Scholar 

  24. J Heffron (1999) ArticleTitleEndocrine disrupters. Are they an insidious risk to health Biochemist 1999 28–31

    Google Scholar 

  25. EK Tangani S Ponchaut M Maudoux R Rozenberg Y Larondelle (2002) ArticleTitleOchratoxin A in domestic and imported beers in Belgium: occurrence and exposure assessment Food Add. Contam. 19 1169–1179 Occurrence Handle10.1080/02652030210007859 Occurrence Handle1:CAS:528:DC%2BD3sXhsFWnsLc%3D

    Article  CAS  Google Scholar 

  26. FS Chu GY Li (1994) ArticleTitleSimultaneous occurrence of fumonisin B1and other mycotoxins in moldy corn collected from the people’s Republic of China in regions with high incidences of esophageal cancer Appl. Environ. Microbiol. 60 847–852 Occurrence Handle8161178 Occurrence Handle1:CAS:528:DyaK2cXitFGlsL0%3D

    PubMed  CAS  Google Scholar 

  27. AE Desjardins TM Hohn SP McCormick (1993) ArticleTitleTrichothercene biosynthesis in Fusarium species: chemistry, genetics and significance Microbiol. Rev. 57 595–604 Occurrence Handle8246841 Occurrence Handle1:CAS:528:DyaK3sXmsVGjs7o%3D

    PubMed  CAS  Google Scholar 

  28. MS Zuber LL Darrah EB Lillehoj LM Josephson A Manwiller GE Scott RT Gudauskas ES Horner NW Widstrom DL Thomposn AJ Bockholt JL Brewbaker (1993) ArticleTitleComparison of open-pollinated maize varieties and hybrids for preharvest aflatoxin contamination in the southern United States Plant Dis. 67 185–187

    Google Scholar 

  29. V Carballoso-Torrecilla A Mejia-Contreras S Valderrama-Castro A Carballo-Carballo FV Gonzalez-Cossio (2000) ArticleTitleDivergence in native maize populations in high valleys of Mexico Agrociencia 34 167–174

    Google Scholar 

  30. HH Iltis JF Doebley MR Guzman B Pazy (1979) ArticleTitleZea diploperennis (Graminiae): a new teosinte from Mexico Science 230 186–187

    Google Scholar 

  31. JR Wallin NW Widstrom BA Fortnum (1991) ArticleTitleMaize populations with resistance to field contamination by aflatoxin B1 J. Sci. Food Agric. 54 235–238 Occurrence Handle1:CAS:528:DyaK3MXhs1SqsL4%3D

    CAS  Google Scholar 

  32. LM Maupin MJ Clements SL Walker DG White (2002) ArticleTitleEffect of CryIA (b) on Aspergillus ear rot and aflatoxin production in commercial corn hybrids Mycopathologia 155 106

    Google Scholar 

  33. CM Bucio-Villalobos D Guzmán-de-Peña JJ Peña-Cabriales (2001) ArticleTitleAflatoxin synthesis in corn fields in Guanajuato, Mexico Rev. Iberam. Micol 18 83–87 Occurrence Handle1:STN:280:DC%2BD2M3jtVWmtw%3D%3D

    CAS  Google Scholar 

  34. LA Rodriguez-del-Bosque (1996) ArticleTitleImpact of agronomic factor on aflatoxin contamination in preharvest field corn in Northeastern Mexico Plant Dis. 80 988–993 Occurrence Handle1:CAS:528:DyaK28XlslKmuro%3D Occurrence Handle10.1094/PD-80-0988

    Article  CAS  Google Scholar 

  35. LA Rodriguez-del-Bosque J Leos-Martinez PF Dowd (1998) ArticleTitleEffect of ear wounding and cultural practices on abundance of Carpohilus freemani (Coleoptera: Nitiduliade) and other microelopterans in maize in northeastern Mexico J. Econ. Entomol. 91 796–801

    Google Scholar 

  36. E Moreno-Martinez M Vazquez-Badillo F Facio-Parra (2000) ArticleTitleThe use of propionic acid salts to inhibit aflatoxin production in stores grains of maize Agrociencia 34 477–484

    Google Scholar 

  37. I Vargas-Arispuro S Araujo-Bernal MA Martinez-Telles M Ortega-Nieblas (1997) ArticleTitleEfecto de extractos de plantas sobre el crecimiento y producción de aflatoxinas de Aspergillus flavus y Aspergillus parasiticus Rev. Mex. Fitopatol. 15 91–95

    Google Scholar 

  38. R Montes-Belmont M Carvajal (1998) ArticleTitleControl of Aspergillus flavus in maize with plant essential oils and their components J. Food Prot. 61 616–619 Occurrence Handle9709236 Occurrence Handle1:CAS:528:DyaK1cXjsVSrur8%3D

    PubMed  CAS  Google Scholar 

  39. E García N Heredia S García (2005) ArticleTitleInhibition of growth and mycotoxin production of Aspergillus flavus and Aspergillus parasiticus by extracts of Agave species Int. J. Food Micro. 98 271–279 Occurrence Handle10.1016/j.ijfoodmicro.2004.07.009 Occurrence Handle1:CAS:528:DC%2BD2MXhtVOku7Y%3D

    Article  CAS  Google Scholar 

  40. LA Golblatt (1066) ArticleTitleSome approaches to the elimination of aflatoxin from protein concentrates Advan. Chem. Ser. 57 216–227 Occurrence Handle10.1021/ba-1966-0057.ch015

    Article  Google Scholar 

  41. D Guzman Peña Particlede L Trudel GN Wogan (1995) ArticleTitleCorn nixtamalization and the fate of radiolabelled aflatoxin B1 in the tortilla making process Bull. Environ. Toxicol. 55 858–864

    Google Scholar 

  42. Torres PI, Guzman M, Ramirez-Wong B, Detoxification of aflatoxin contaminated corn during the tortilla and deep fat frying process. Proceedings of Modulation of Chemical Toxicity and Risk Assessment Conference. University of Arizona, Tucson AZ, 1996; 9–12 June. http://jeeves.pharmacy.arizona.edu/conf/sponsors.html

  43. PI Torres M Guzman-Ortiz B Ramírez-Wong (2001) ArticleTitleRevising the role of pH and thermal treatments in aflatoxin content reduction during the tortilla and deep frying process J. Agric. Food Chem. 49 2825–2829 Occurrence Handle11409972 Occurrence Handle1:CAS:528:DC%2BD3MXms1OjtLs%3D Occurrence Handle10.1021/jf010368v

    Article  PubMed  CAS  Google Scholar 

  44. RL Price KV Jorgensen (1985) ArticleTitleEffects of processing on aflatoxin levels and mutagebic potential of tortillas made from naturally contaminated corn J. Food Sci. 50 347–357 Occurrence Handle1:CAS:528:DyaL2MXhsVOltbc%3D Occurrence Handle10.1111/j.1365-2621.1985.tb13398.x

    Article  CAS  Google Scholar 

  45. R Elias-Orozco A Castellanos-Nava M Gaytan-Martinez JD Figueroa-Cardenas G Lorca-Piña (2002) ArticleTitleComparison of nixtamalization and extrusion process for reduction in aflatoxin content Food Addit. Contam. 19 878–885 Occurrence Handle12396399 Occurrence Handle1:CAS:528:DC%2BD38XotFeksLo%3D Occurrence Handle10.1080/02652030210145054

    Article  PubMed  CAS  Google Scholar 

  46. R la Campa ParticleDe JD Millar K Hendrics (2004) ArticleTitleFumonisin in tortillas produced in small-scale facilities and effect of traditional masa production methods on this micotoxin J. Agric. Food Chem. 52 4432–4437 Occurrence Handle15237948 Occurrence Handle10.1021/jf035160j Occurrence Handle1:CAS:528:DC%2BD2cXlsFKlsL4%3D

    Article  PubMed  CAS  Google Scholar 

  47. EW Sydenham S Stockenstrom PG Thiel GS Shephard KR Koch WFO Marasas (1995) ArticleTitlePotential of alkaline hydrolysis for the removal of fumonisins from contaminated corn J. Agric. Food Chem. 43 1198–1201 Occurrence Handle1:CAS:528:DyaK2MXlsFelsb8%3D Occurrence Handle10.1021/jf00053a014

    Article  CAS  Google Scholar 

  48. MA Dombrink-Kurtzman TJ Dvorak (1999) ArticleTitleFumonisin content in masa and tortillas from Mexico J. Agric. Food Chem. 47 622–627 Occurrence Handle10563942 Occurrence Handle1:CAS:528:DyaK1MXitlyksw%3D%3D Occurrence Handle10.1021/jf9807162

    Article  PubMed  CAS  Google Scholar 

  49. JW Dorner RJ Cole UL Diener (1984) ArticleTitleThe relationship of Aspergillus flavus and Aspergillus parasiticus with reference to production of aflatoxins and Cyclopiazonic acid Mycopathologia 87 13–15 Occurrence Handle6436707 Occurrence Handle1:CAS:528:DyaL2MXitVynug%3D%3D Occurrence Handle10.1007/BF00436617

    Article  PubMed  CAS  Google Scholar 

  50. ML Martines HM Martines (1999) ArticleTitleNatural and in vitro coproduction of Cyclopiazonic acid on pregnant and fetal development of Fischer rats J. Toxicol. Environ. Health 14 585–594

    Google Scholar 

  51. D Cazzaniga JC Basilico RJ Gonzalez RL Torres DM Greef Particlede (2001) ArticleTitleMycotoxins inactivation by extrusion cooking of corn flour Lett. Appl. Microbiol. 33 144–147 Occurrence Handle11472523 Occurrence Handle1:CAS:528:DC%2BD3MXmt1Sntb0%3D Occurrence Handle10.1046/j.1472-765x.2001.00968.x

    Article  PubMed  CAS  Google Scholar 

  52. R Montes-Belmont I Mendez-Ramirez HF Flores-Moctezuma RA Nava-Juarez (2003) ArticleTitleImpact of planting and climate factors on the incidence and severity of sorghum grain mold in Morelos Mexico Plant Dis. 87 1139–1143

    Google Scholar 

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García, S., Heredia, N. Mycotoxins in Mexico: Epidemiology, management, and control strategies. Mycopathologia 162, 255–264 (2006). https://doi.org/10.1007/s11046-006-0058-1

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