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Efficacy of voriconazole in experimental Cryptococcus neoformans infection

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Abstract

Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug’s effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.

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Authors and Affiliations

  1. Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA

    Nikolaos Mavrogiorgos, Arturo Casadevall & Joshua D. Nosanchuk

  2. Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA

    Oscar Zaragoza, Arturo Casadevall & Joshua D. Nosanchuk

  3. Boston University Medical Center, Boston, MA, USA

    Nikolaos Mavrogiorgos

Authors
  1. Nikolaos Mavrogiorgos
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  2. Oscar Zaragoza
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  3. Arturo Casadevall
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  4. Joshua D. Nosanchuk
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Corresponding author

Correspondence to Joshua D. Nosanchuk.

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Mavrogiorgos, N., Zaragoza, O., Casadevall, A. et al. Efficacy of voriconazole in experimental Cryptococcus neoformans infection. Mycopathologia 162, 111–114 (2006). https://doi.org/10.1007/s11046-006-0039-4

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  • DOI: https://doi.org/10.1007/s11046-006-0039-4

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