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Phospholipase and Proteinase Activities of Clinical Isolates of Candida from Immunocompromised Patients

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Abstract

Sixty-one isolates of Candida recovered from HIV seropositive and cancer patients were studied for elaboration of putative virulence determinants – phospholipase (PL) and secreted aspartyl proteinase (Sap). Forty two (68.85%) isolates examined were PL producers and 51 (83.6%) were positive for Sap. 57.37% (35/61) isolates produced both enzymes. Enzymatic activity was more pronounced in Candida albicans with 100% PL and 94.1% Sap activity. In contrast, non-C. albicans species demonstrated only 29.6% PL and 70.3% Sap activity, indicating interplay of other virulence determinants in these yeasts in colonization and disease.

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Authors and Affiliations

  1. Department of Microbiology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani,Chennai, 600 113, India

    C. P. Girish Kumar, S. Suresh Jothi Kumar & Thangam Menon

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  1. C. P. Girish Kumar
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  2. S. Suresh Jothi Kumar
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  3. Thangam Menon
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Correspondence to Thangam Menon.

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Kumar, C.P.G., Kumar, S.S.J. & Menon, T. Phospholipase and Proteinase Activities of Clinical Isolates of Candida from Immunocompromised Patients. Mycopathologia 161, 213–218 (2006). https://doi.org/10.1007/s11046-005-0157-4

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  • DOI: https://doi.org/10.1007/s11046-005-0157-4

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