Abstract
Ovarian cancer is a global health concern due to the unavailability of an effective screening strategy and is often diagnosed at a late stage with approximately 70% of the case which reduces the survival chances of patients. Initial diagnosis is challenging due to inconspicuous symptoms in its initial stages which complicate its timely diagnosis. Regular screenings, such as pelvic exams, ultrasounds, and blood tests targeting specific biomarkers can be helpful for early diagnosis. In addition, the use of machine learning models can help automate this process thereby assisting medical experts for accurate diagnosis. This study aims at timely and accurate detection of ovarian cancer using a transfer learning approach that uses the MobileNet model. Moreover, the Chi-square technique is used to extract the most impactful features for better accuracy. For experiments, the Soochow University ovarian cancer dataset is employed. Extensive experiments are performed using all features from the dataset, as well as, using Chi-square-based selective features. The best accuracy of 90.88% is achieved with the Xception model when all features are used. Experimental results show a substantial increase when selective features are used indicating a 98.49% accuracy using the MobileNet model with 20 most important features. In addition, precision, recall, and F1 scores of 99.13%, 99.27%, and 99.20% are obtained showing the model’s robustness and generalization. This study also employs Shapley additive explanations to explain the importance of various features toward the model’s output thereby providing transparency for the model’s decision-making process.
Similar content being viewed by others
Data Availability
The datasets generated during and/or analyzed during the current study is available from the corresponding author on reasonable request.
References
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61(2):69–90
Reid BM, Permuth JB, Sellers TA (2017) Epidemiology of ovarian cancer: A review. Cancer Biol Med 14(1):9
Vázquez MA, Mariño IP, Blyuss O, Ryan A, Gentry-Maharaj A, Kalsi J, Manchanda R, Jacobs I, Menon U, Zaikin A (2018) A quantitative performance study of two automatic methods for the diagnosis of ovarian cancer. Biomed Signal Process Control 46:86–93
Jayson GC, Kohn EC, Kitchener HC, Ledermann JA (2014) Ovarian cancer. The Lancet 384(9951):1376–1388
Kommoss S, Pfisterer J, Reuss A, Diebold J, Hauptmann S, Schmidt C, du Bois A, Schmidt D, Kommoss F (2013) Specialized pathology review in patients with ovarian cancer: Results from a prospective study. International Journal of Gynecologic Cancer 23(8)
Jeong YY, Outwater EK, Kang HK (2000) Imaging evaluation of ovarian masses. Radiographics 20(5):1445–1470
Iyer VR, Lee SI (2010) MRI, CT, and PET/CT for ovarian cancer detection and adnexal lesion characterization. Am J Roentgenol 194(2):311–321
Kinkel K, Lu Y, Mehdizade A, Pelte MF, Hricak H (2005) Indeterminate ovarian mass at US: Incremental value of second imaging test for characterization–meta-analysis and Bayesian analysis. Radiology 236(1):85–94
Moore BJ, Steiner CA, Davis PH, Stocks C, Barrett ML (2017) Trends in hysterectomies and oophorectomies in hospital inpatient and ambulatory settings, 2005–2013
Lass A (1999) The fertility potential of women with a single ovary. Hum Reprod Update 5(5):546–550
Parker WH, Broder MS, Berek JS, Liu Z, Shoupe D, Farquhar JS (2005) Ovarian conservation at the time of hysterectomy for benign disease. Obstetrics & Gynecology 106(5 Part 1):1107
Senders JT, Staples PC, Karhade AV, Zaki MM, Gormley WB, Broekman ML, Smith TR, Arnaout O (2018) Machine learning and neurosurgical outcome prediction: A systematic review. World Neurosurg 109:476–486
Langerhuizen DW, Janssen SJ, Mallee WH, Van Den Bekerom MP, Ring D, Kerkhoffs GM, Jaarsma RL, Doornberg JN (2019) What are the applications and limitations of artificial intelligence for fracture detection and classification in orthopaedic trauma imaging? A systematic review. Clin Orthop Relat Res 477(11):2482
Chilamkurthy S, Ghosh R, Tanamala S, Biviji M, Campeau NG, Venugopal VK, Mahajan V, Rao P, Warier P (2018) Deep learning algorithms for detection of critical findings in head CT scans: A retrospective study. The Lancet 392(10162):2388–2396
Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, Thrun S (2017) Dermatologist-level classification of skin cancer with deep neural networks. Nature 542(7639):115–118
Gulshan V, Peng L, Coram M, Stumpe MC, Wu D, Narayanaswamy A, Venugopalan S, Widner K, Madams T, Cuadros J et al (2016) Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. Jama 316(22):2402–2410
Chen X, Aljrees T, Umer M, Saidani O, Almuqren L, Mzoughi O, Ishaq A, Ashraf I (2023) Cervical cancer detection using K nearest neighbor imputer and stacked ensemble learningmodel. Digital Health 9:20552076231203800
Ishaq A, Sadiq S, Umer M, Ullah S, Mirjalili S, Rupapara V, Nappi M (2021) Improving the prediction of heart failure patients’ survival using SMOTE and effective data mining techniques. IEEE Access 9:39707–39716
William W, Ware A, Basaza-Ejiri AH, Obungoloch J (2018) A review of image analysis and machine learning techniques for automated cervical cancer screening from pap-smear images. Comput Methods Programs Biomed 164:15–22
Fernandes K, Cardoso JS, Fernandes J (2018) Automated methods for the decision support of cervical cancer screening using digital colposcopies. Ieee Access 6:33910–33927
Maria HH, Jossy AM, Malarvizhi S (2022) A machine learning approach for classification of ovarian tumours. In: Journal of physics: Conference series (IOP Publishing, 2022) 2335(1): 012018
Lu M, Fan Z, Xu B, Chen L, Zheng X, Li J, Znati T, Mi Q, Jiang J (2020) Using machine learning to predict ovarian cancer. Int J Med Inform 141:104195
Ahamad MM, Aktar S, Uddin MJ, Rahman T, Alyami SA, Al-Ashhab S, Akhdar HF, Azad A, Moni MA (2022) Early-stage detection of ovarian cancer based on clinical data using machine learning approaches. J Pers Med 12(8):1211
Xie Y (2022) Group penalized logistic regressions predict ovarian cancer
Han AF, Emedom-Nnamdi P (2021) Predicting ovarian cancer using regularized logistic regression
Kasture KR et al (2021) A new deep learning method for automatic ovarian cancer prediction & subtype classification. Turkish Journal of Computer and Mathematics Education (TURCOMAT) 12(12):1233–1242
Ghoniem RM, Algarni AD, Refky B, Ewees AA (2021) Multi-modal evolutionary deep learning model for ovarian cancer diagnosis. Symmetry 13(4):643
Azar AS, Rikan SB, Naemi A, Mohasefi JB, Pirnejad H, Mohasefi MB, Wiil UK (2022) Application of machine learning techniques for predicting survival in ovarian cancer. BMC Med Inform Decis Mak 22(1):345
Kalaiyarasi M, Rajaguru H (2022) Performance analysis of ovarian cancer detection and classification for microarray gene data. BioMed Research International 2022
Akazawa M, Hashimoto K (2020) Artificial intelligence in ovarian cancer diagnosis. Anticancer research 40(8):4795–4800
Ziyambe B, Yahya A, Mushiri T, Tariq MU, Abbas Q, Babar M, Albathan M, Asim M, Hussain A, Jabbar S (2023) A deep learning framework for the prediction and diagnosis of ovarian cancer in pre-and post-menopausal women. Diagnostics 13(10):1703
Mi Q, Jingting Z, Ty F, Zhenjiang L, Jundong X, Bin C, Lujun Z, Xiao L et al (2020) Data for: Using machine learning to predict ovarian cancer. Mendeley Data, Version 11
Ahmad MA, Eckert C, Teredesai A (2018) Interpretable machine learning in healthcare. In: Proceedings of the 2018 ACM international conference on bioinformatics, computational biology, and health informatics, pp 559–560
Lundberg SM, Lee SI (2017) A unified approach to interpreting model predictions. Advances in Neural Information Processing Systems 30
Narra M, Umer M, Sadiq S, Karamti H, Mohamed A, Ashraf I et al (2022) Selective feature sets based fake news detection for COVID-19 to manage infodemic. IEEE Access 10:98724–98736
Juna A, Umer M, Sadiq S, Karamti H, Eshmawi A, Mohamed A, Ashraf I (2022) Water quality prediction using KNN imputer and multilayer perceptron. Water 14(17):2592
Alturki N, Umer M, Ishaq A, Abuzinadah N, Alnowaiser K, Mohamed A, Saidani O, Ashraf I (2023) Combining CNN features with voting classifiers for optimizing performance of brain tumor classification. Cancers 15(6):1767
Cascone L, Sadiq S, Ullah S, Mirjalili S, Siddiqui HUR, Umer M (2023) Predicting household electric power consumption using multi-step time series with convolutional LSTM. Big Data Research 31:100360
Wang ZY, Xia QM, Yan JW, Xuan SQ, Su JH, Yang CF (2019) Hyperspectral image classification based on spectral and spatial information using multi-scale ResNet. Appl Sci 9(22):4890
Zulfiqar F, Bajwa UI, Mehmood Y (2023) Multi-class classification of brain tumor types from MR images using EfficientNets. Biomed Signal Process Control 84:104777
Mujahid M, Rustam F, Álvarez R, Mazón JLV, Díez IdlT, Ashraf I (2022) Pneumonia classification from X-ray images with inception-V3 and convolutional neural network. Diagnostics 12(5):1280
Salim F, Saeed F, Basurra S, Qasem SN, Al-Hadhrami T (2023) DenseNet-201 and xception pre-trained deep learning models for fruit recognition. Electronics 12(14):3132
Srinivasu PN, SivaSai JG, Ijaz MF, Bhoi AK, Kim W, Kang JJ (2021) Classification of skin disease using deep learning neural networks with MobileNet V2 and LSTM. Sensors 21(8):2852
Acknowledgements
This research is funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2024R410), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. This study is supported via funding from Prince Sattam bin Abdulaziz University project number (PSAU/2024/R/1445).
Funding
The authors are thankful to Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2024R410), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. This study is supported via funding from Prince Sattam bin Abdulaziz University project number (PSAU/2024/R/1445).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflicts of interest
The authors declare no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Almujally, N.A., Alzahrani, A., Hakeem, A.M. et al. Selective feature-based ovarian cancer prediction using MobileNet and explainable AI to manage women healthcare. Multimed Tools Appl (2024). https://doi.org/10.1007/s11042-024-19286-6
Received:
Revised:
Accepted:
Published:
DOI: https://doi.org/10.1007/s11042-024-19286-6