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Molecular characterization of Staphylococcus aureus isolated from hospital-acquired infections in Ilam, Iran

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Abstract

Objective

This research study was undertaken to investigate antimicrobial resistance patterns and the prevalence of hospital-acquired infections (HAIs). The study focuses on common microorganisms responsible for HAIs and explores emerging challenges posed by antimicrobial drug-resistant isolates.

Methods

A comprehensive analysis of 123 patients with HAIs, hospitalized in surgical department and intensive care unit (ICU) at Imam Khomeini Hospital, Ilam, Iran, was conducted over a six-month period. Pathogenic bacterial isolates, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA), were isolated and subjected to antibiotic susceptibility testing.

Results

The study findings revealed a significant prevalence of multidrug-resistant (MDR) isolates, of which 73.3% were MRSA. Notably, 6.7% of S. aureus isolates exhibited resistance to vancomycin, indicating the emergence of VRSA. Respiratory infections were identified as the most prevalent HAI, constituting 34.67% of cases, often arising from extended ICU stays and invasive surgical procedures. Furthermore, patients aged 60 and above, particularly those associated with MDR, exhibited higher vulnerability to HAI.

Conclusions

This research sheds light on the intricate interplay between drug resistance and HAI, highlighting the imperative role of rational antibiotic use and infection control in addressing this critical healthcare challenge.

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Data availability

No datasets were generated or analysed during the current study.

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Funding

The authors received no funding for this work.

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Authors and Affiliations

  1. Department of Microbiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran

    Somayeh Karamolahi, Marzieh Hashemian & Nourkhoda Sadeghifard

  2. Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran

    Vahab Hassan Kaviar, Mohammad Hossein Haddadi, Nourkhoda Sadeghifard & Saeed Khoshnood

  3. Department of Infectious Diseases, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran

    Jalil Feizi

Authors
  1. Somayeh Karamolahi
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  2. Vahab Hassan Kaviar
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  4. Marzieh Hashemian
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Contributions

Nourkhoda Sadeghifard contributed to the study conception and design. Data collection and analysis were performed by Somayeh Karamolahi, Saeed Khoshnood, Vahab Hassan Kaviar, Marzieh Hashemian, and Jalil Feizi. The first draft of the manuscript was written by Somayeh Karamolahi and Saeed Khoshnood, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Nourkhoda Sadeghifard or Saeed Khoshnood.

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The authors report no conflict of interest in this study.

Ethical approval

The study protocol was approved by the local ethics committee of Ilam University of Medical Sciences Iran. Written informed consent was received from each patient.

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The authors declare no competing interests.

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Karamolahi, S., Kaviar, V.H., Haddadi, M.H. et al. Molecular characterization of Staphylococcus aureus isolated from hospital-acquired infections in Ilam, Iran. Mol Biol Rep 51, 686 (2024). https://doi.org/10.1007/s11033-024-09580-9

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