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Advances in polysaccharides of natural source of anti-diabetes effect and mechanism

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Abstract

Purpose

Diabetes is a chronic disease in metabolic disorder, and the pathology is characterized by insulin resistance and insulin secretion disorder in blood. In current, many studies have revealed that polysaccharides extracted from natural sources with significant anti-diabetic effects. Natural polysaccharides can ameliorate diabetes through different action mechanisms. All these polysaccharides are expected to have an important role in the clinic.

Methods

Existing polysaccharides for the treatment of diabetes are reviewed, and the mechanism of polysaccharides in the treatment of diabetes and its structural characteristics are described in detail.

Results

This article introduced the natural polysaccharide through different mechanisms of action in the treatment of diabetes, including oxidative stress, apoptosis, inflammatory response and regulation of intestinal bacteria. Natural polysaccharides can treat of diabetes by regulating signaling pathways is also a research hotspot. In addition, the structural characteristics of polysaccharides were explored. There are some structure–activity relationships between natural polysaccharides and the treatment of diabetes.

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Data availability

All data generated or analyzed during this study are included in this published article.

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This work is supported by grants from the National Science Foundation of China (Grant No. 82160786).

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Authors and Affiliations

  1. Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang, 550001, China

    Mao-Hui Yang, Yan Yang, Xin Zhou & Hua-Guo Chen

  2. Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, Guizhou Normal University, Guiyang, 550001, China

    Mao-Hui Yang, Yan Yang, Xin Zhou & Hua-Guo Chen

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  1. Mao-Hui Yang
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  2. Yan Yang
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  3. Xin Zhou
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  4. Hua-Guo Chen
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M-HY: devised, structured, and wrote the manuscript. All the authors reviewed and corrected the manuscript.

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Correspondence to Hua-Guo Chen.

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Yang, MH., Yang, Y., Zhou, X. et al. Advances in polysaccharides of natural source of anti-diabetes effect and mechanism. Mol Biol Rep 51, 101 (2024). https://doi.org/10.1007/s11033-023-09081-1

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