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SBF2-AS1 and TreRNA: novel lncRNA players in triple-negative breast cancer pathogenesis

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Abstract

Background

Compared to other breast cancer subtypes, triple-negative breast cancer (TNBC) has always been challenging for clinicians due to its aggressive behavior and lack of a specific treatment. There is a confirmed association between invasive features of tumors and increased epithelial-mesenchymal transition (EMT) process, which is consistent with a higher rate of EMT in TNBC.

Methods and results

We investigated the expression of EMT-related genes, SNAI1 and MMP7, and EMT-related lncRNAs, treRNA and SBF2-AS1, in 50 TNBC tumors and 50 non-TNBC tumors to reveal more regulators and effectors involved in TNBC malignancy. In the present study, we showed the overexpression of all the studied genes and lncRNAs in TNBC tumors compared to non-TNBC samples. Moreover, a significant association was observed between MMP7 and treRNA expression levels and larger tumor size. A positive correlation between SNAI1 and lncRNA treRNA expression levels was also detected.

Conclusions

Due to the differential expression and the potential diagnostic power of the studied genes, SBF2-AS1 and treRNA can be proposed as new probable biomarkers and therapeutic targets in TNBC.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

Current research has been adopted from the PhD thesis of Ms Zeeba Kamaliyan in School of Medicine, Shahid Beheshti University of Medical Sciences and was financially supported by the “Research Department of the School of Medicine, Shahid Beheshti University of Medical Sciences” (Code 25169).

Author information

Authors and Affiliations

  1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Koodakyar St, Velenjak Ave, Chamran Highway, Tehran, 19395-4719, Iran

    Zeeba Kamaliyan, Ghasem Azizi-Tabesh, Vahid-Reza Yassaee & Reza Mirfakhraie

  2. Department of Biology, Faculty of Biological Sciences, Tehran North Branch, Islamic Azad University, Tehran, Iran

    Kimia Dorraji & Setare Kakavand

  3. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Ghasem Azizi-Tabesh & Vahid-Reza Yassaee

  4. Department of computer engineering, Tehran North Branch, Islamic Azad University, Tehran, Iran

    Nikta Mirfakhraie

  5. Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran

    Ramesh Omranipour

  6. Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

    Ramesh Omranipour

  7. Medical imaging center, Cancer Research Institute, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran

    Nasrin Ahmadinejad

  8. Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Reza Mirfakhraie

Authors
  1. Zeeba Kamaliyan
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  2. Kimia Dorraji
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Contributions

ZK and RM contributed to the study conception and design. Samples collection, material preparation and data analysis were performed by ZK, GA, KD, SK, RO and NA. The first draft of the manuscript was written by ZK and KD, and finally revised by RM, NM, and VY. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Reza Mirfakhraie.

Ethics declarations

Ethics approval

This research was conducted in compliance with the ethical principles of Helsinki Declaration and under the protocols of Ethics committee of SBMU (code: IR.SBMU.MSP.REC.1398.576).

Consent to participate

The informed consent was taken from all the patients who participated in this study.

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The authors report no conflict of interests associated with this manuscript.

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Kamaliyan, Z., Dorraji, K., Kakavand, S. et al. SBF2-AS1 and TreRNA: novel lncRNA players in triple-negative breast cancer pathogenesis. Mol Biol Rep 50, 6029–6037 (2023). https://doi.org/10.1007/s11033-023-08533-y

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  • DOI: https://doi.org/10.1007/s11033-023-08533-y

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