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Interleukin-16 genetic polymorphisms in Guangxi Chinese with hepatitis B virus-related liver cirrhosis

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Abstract

Background

Our previous study has reported that interleukin-16 (IL-16) genetic polymorphisms are significantly related to chronic hepatitis B (CHB) and hepatitis B virus-related (HBV-related) hepatocellular carcinoma (HCC). As CHB, liver cirrhosis (LC), and HCC are development processes, this study aimed to determine genetic correlation of IL-16 polymorphisms with HBV-related LC in a Chinese population.

Methods

IL-16 gene rs11556218, rs4072111, and rs4778889 polymorphism in 129 patients with HBV-related LC and 168 healthy individuals were genotyped via polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). PCR–RFLP results were verified by DNA sequencing.

Results

The allelic and genotypic distributions of IL-16 rs11556218, rs4072111, and rs4778889 polymorphisms in HBV-related LC patients showed no significant difference from those in healthy controls. Furthermore, no relationship was observed between the haplotype distribution and susceptibility to HBV-related LC.

Conclusions

This work provided the first evidence that the IL-16 genetic polymorphisms may not be associated with HBV-related LC risk.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

Author information

Author notes

  1. Xiaolian Zhang and Wenjun Tang are co-first authors.

Authors and Affiliations

  1. Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

    Xiaolian Zhang, Xue Qin & Shan Li

  2. Department of Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China

    Wenjun Tang

  3. Medical Equipment Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

    Dong Liang

Authors
  1. Xiaolian Zhang
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  2. Wenjun Tang
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  3. Xue Qin
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  4. Shan Li
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  5. Dong Liang
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by XZ and WT. The first draft of the manuscript was written by XZ and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Shan Li or Dong Liang.

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Competing interests

The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

This study was approved by the Ethics Committee of the First Affiliated Hospital of Guangxi Medical University. All subjects included in this study previously provided informed consent.

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Shan Li and Dong Liang are corresponding authors.

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Zhang, X., Tang, W., Qin, X. et al. Interleukin-16 genetic polymorphisms in Guangxi Chinese with hepatitis B virus-related liver cirrhosis. Mol Biol Rep 50, 5247–5254 (2023). https://doi.org/10.1007/s11033-023-08450-0

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  • DOI: https://doi.org/10.1007/s11033-023-08450-0

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