Skip to main content
SpringerLink
Log in

Association of DRB1*11 and DRB1*12 alleles of the HLA system with the evolution of the Hepatitis B virus infection in Burkina Faso

  • Original Article
  • Published:
Molecular Biology Reports Aims and scope Submit manuscript

Abstract

Background

Hepatitis B Virus (HBV) infection affect all social strata of humanity and in the absence of any management, this infection has a different outcome from one infected person to another. This suggests that there are specific individual factors that influence the outcome of the pathology. Sex, immunogenetics and age of contraction of the virus have been cited as factors that influence the evolution of the pathology. In this study, we looked at two alleles of the Human Leucocyte Antigen (HLA) system to measure their possible involvement in the evolution of HBV infection.

Method and results

We conducted a cohort study involving 144 individuals spread over 04 distinct stages of infection and then compared allelic frequencies in these populations. A multiplex PCR was conducted and the data obtained was analyzed using R and SPSS software. Our study revealed a predominance of HLA-DRB1*12 in our study population without, however, showing a significant difference between HLA-DRB1*11 and HLA-DRB1*12. The HLA-DRB1*12 proportion was significantly higher in chronic hepatitis B (CHB) and resolved hepatitis B (RHB) compared to cirrhosis and hepatocellular carcinoma (HCC) (p-value = 0,002). Carrying HLA-DRB1*12 has been associated with a low risk of complication of infection (CHB → cirrhosis; OR 0,33 p-value 0,017; RHB → HCC OR 0,13; p-value = 0,00,045) whereas the presence of HLA-DRB1*11 in the absence of HLA-DRB1*12 increased the risk of developing severe liver disease. However, a strong interaction of these alleles with the environment could modulate the infection.

Conclusion

Our study shown that HLA-DRB1*12 is the most frequent and it’s carriage may be protective in the development of infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Data availability

Data will be made available on reasonable request.

References

  1. Blumberg BS (1965) A new antigen in leukemia sera. JAMA 191(7):541–546

    Article  CAS  PubMed  Google Scholar 

  2. Zhang S. HLA Class II Allele Polymorphisms and the Clinical Outcomes of HBV Infection. Human Leukocyte Antigen (HLA) [Internet]. 13 mars 2019 [cité 9 avr 2021]; Disponible sur: https://www.intechopen.com/books/human-leukocyte-antigen-hla-/hla-class-ii-allele-polymorphisms-and-the-clinical-outcomes-of-hbv-infection

  3. OMS. Lignes Directrices Pour La Prévention, Les Soins et Le Traitement En Faveur Des Personnes Atteintes d’une Infection à Hépatite b Chronique. 2015.

  4. OMS. Hepatitis B [Internet]. 2022 [cité 17 janv 2023]. Disponible sur: https://www.who.int/news-room/fact-sheets/detail/hepatitis-b

  5. McMahon BJ (2005) Epidemiology and natural history of hepatitis B. Semin Liver Dis 25(Suppl 1):3–8

    Article  PubMed  Google Scholar 

  6. Hui CK, Leung N, Yuen ST, Zhang HY, Leung KW, Lu L et al (2007) Natural history and disease progression in Chinese chronic hepatitis B patients in immune-tolerant phase. Hepatology août 46(2):395–401

    Article  Google Scholar 

  7. Han KH, Kim KH, Chang HY (2002) Immunogenetics of hepatitis B virus infection. J Gastroenterol Hepatol déc 17(Suppl 3):S329-332

    Article  Google Scholar 

  8. Klein J, Sato A (2000) The HLA system: second of two parts. N Engl J Med 343(11):782–786

    Article  CAS  PubMed  Google Scholar 

  9. Kew MC, Gear AJ, Baumgarten I, Dusheiko GM, Maier G (1979) Histocompatibility antigens in patients with hepatocellular carcinoma and their relationship to chronic hepatitis B virus infection in these patients. Gastroenterology sept 77(3):537–539

    Article  CAS  Google Scholar 

  10. Wang L, Zou ZQ, Wang K. Clinical Relevance of HLA Gene Variants in HBV Infection. J Immunol Res [Internet]. 2016 [cité 18 avr 2021];2016. Disponible sur: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875979/

  11. Tai DI, Lin SM, Sheen IS, Chu CM, Lin DY, Liaw YF (2009) Long-term outcome of hepatitis B e antigen–negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over time. Hepatology 49(6):1859–1867

    Article  CAS  PubMed  Google Scholar 

  12. Ramezani A, Aghakhani A, Kalantar E, Banifazl M, Eslamifar A, Velayati AA. Association between Hepatitis B Virus Infection Outcome and HLA-A and DRB1 Genotyping in North Part of Iran. 2009;5.

  13. Yang G, Liu J, Han S, Xie H, Du R, Yan Y et al (2007) Association between hepatitis B virus infection and HLA-DRB1 genotyping in Shaanxi Han patients in northwestern China. Tissue Antigens févr 69(2):170–175

    Article  CAS  Google Scholar 

  14. Ma S, Wu J, Wu J, Wei Y, Zhang L, Ning Q et al (2016) Relationship between HLA-DRB1 Allele polymorphisms and familial aggregations of hepatocellular carcinoma. Curr Oncol 23(1):1–7

    Article  CAS  Google Scholar 

  15. Ramezani A, Roshan MRH, Kalantar E, Eslamifar A, Banifazl M, Taeb J et al (2008) Association of human leukocyte antigen polymorphism with outcomes of hepatitis B virus infection. J Gastroenterol Hepatol 23(11):1716–1721

    Article  PubMed  Google Scholar 

  16. Han YN, Yang JL, Zheng SG, Tang Q, Zhu W (2005) Relationship of human leukocyte antigen class II genes with the susceptibility to hepatitis B virus infection and the response to interferon in HBV-infected patients. World J Gastroenterol 11(36):5721–5724

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Yan Z, Fan Y, Wang XH, Mao Q, Deng GH, Wang YM (2012) Relationship between HLA-DR gene polymorphisms and outcomes of hepatitis B viral infections: a meta-analysis. World J Gastroenterol : WJG 18:3119–3128

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Singh R, Kaul R, Kaul A, Khan K (2007) A comparative review of HLA associations with hepatitis B and C viral infections across global populations. World J Gastroenterol: WJG 13(12):1770

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Jiang YG, Wang YM, Liu TH, Liu J (2003) Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B. World J Gastroenterol 9(10):2221

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Lin ZH, Xin YN, Dong QJ, Wang Q, Jiang XJ, Zhan SH et al (2010) Association between HLA-DRB1 alleles polymorphism and hepatocellular carcinoma: a meta-analysis. BMC Gastroenterol 10(1):145

    Article  PubMed  PubMed Central  Google Scholar 

  21. Brechot C, Kremsdorf D, Soussan P, Pineau P, Dejean A, Paterlini-Brechot P et al (2010) Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): molecular mechanisms and novel paradigms. Pathol Biol 58(4):278–287

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We would like to thank all the staff of the “Centre medical avec antenne chirurgical Paul VI” and “Centre Hospitalier Universitaire Yalgado Ouedraogo (CHU-YO)” for their help during the sampling. We are grateful to all patients who agreed to voluntarily participate in this study.

Funding

Not Applicable.

Author information

Authors and Affiliations

  1. Laboratoire de Biologie Moléculaire Et de Génétique, Université Joseph KI-ZERBO, P.O. Box 7021, Ouagadougou 03, Burkina Faso

    Sidnooma Véronique Zongo, Florencia Wendkuuni Djigma, Albert Théophane Yonli, Pegdwendé Abel Sorgho, Lassina Traore, Dogfounianalo Somda, Lanyo Jospin Amegnona, Eugène Languie, Roger Arsène Sombie, Abdel Karim Serme & Jacques Simpore

  2. Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), P.O. Box 364, Ouagadougou 01, Burkina Faso

    Florencia Wendkuuni Djigma, Albert Théophane Yonli, Pegdwendé Abel Sorgho, Dogfounianalo Somda, Issa Boaffi Sourabie & Jacques Simpore

  3. Division of Hematology and Oncology, Mayo Clinic, Arizona, 13400 E. Shea Blvd. , Scottsdale, AZ, 85259, USA

    Bolni Marius Nagalo

  4. Centre Hospitalier Universitaire Yalgado Ouedraogo (CHU-YO), P.O. Box: 03 BP 7022, Ouagadougou 03, Burkina Faso

    Couna Christiane Bere Some

  5. Centre Médical Avec Antenne Chirurgical Paul 6, P.O. Box 01 BP 2099, Ouagadougou 01, Burkina Faso

    Lydie Marie Jeannette Sia

  6. Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, PMB, Cape Coast, Cape Coast, Ghana

    Dorcas Obiri-Yeboah

Authors
  1. Sidnooma Véronique Zongo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Florencia Wendkuuni Djigma
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Albert Théophane Yonli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pegdwendé Abel Sorgho
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Bolni Marius Nagalo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lassina Traore
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Dogfounianalo Somda
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Lanyo Jospin Amegnona
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Eugène Languie
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Couna Christiane Bere Some
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Lydie Marie Jeannette Sia
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Issa Boaffi Sourabie
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Roger Arsène Sombie
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Abdel Karim Serme
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Dorcas Obiri-Yeboah
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Jacques Simpore
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors have approved the submitted version of the manuscript. SVZ, FWD, ATY, PAS, MBN and JS: participate to the conception, the design of the work and data acquisition/analysis/interpretation. DS, LJA, EL, CCBS4, LMJS, BS, RAS, LT and A.K.S. contribute for samples acquisition and analysis. D.O.Y contribute for the final validation of the manuscript.

Corresponding author

Correspondence to Florencia Wendkuuni Djigma.

Ethics declarations

Conflict of interest

The author(s) declare(s) that they have no competing interests.

Ethics approval

Our study has received the approval of the Central Regional Direction (DRSC), the national ethics committee in its deliberation number 2022–02-027. In addition, verbal informed consent was obtained from all participants. All the methodology has been performed in accordance with the Declaration of Helsinki.

Consent for publication

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zongo, S.V., Djigma, F.W., Yonli, A.T. et al. Association of DRB1*11 and DRB1*12 alleles of the HLA system with the evolution of the Hepatitis B virus infection in Burkina Faso. Mol Biol Rep 50, 5039–5047 (2023). https://doi.org/10.1007/s11033-023-08353-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11033-023-08353-0

Keywords

Search

Navigation