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The SOCS-1 -1478CA/del functional polymorphism (rs33989964) is associated with gastric cancer but is unrelated to overall survival

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Abstract

Background

In vitro studies have shown that the functional − 1478CA > del polymorphism (rs33989964) of the suppressor of cytokine signaling (SOCS)-1 gene is associated with an altered trascriptional activity. Here, we sought to examine the potential association of this polymorphism with the risk of gastric cancer (GC) and to analyze its prognostic impact on overall survival (OS).

Materials and methods

The study cohort consisted of 74 Turkish patients with GC and 52 healthy controls. Genotyping of the SOCS-1 -1478CA > del polymorphism was carried out using restriction fragment length polymorphism analysis.

Results

After allowance of age and sex, multivariable logistic regression analysis revealed that the carriage of the del allele of the SOCS-1 -1478CA > del polymorphism was independently associated with an increased risk of GC (odds ratio = 6.78, 95% confidence interval = 3.24–10.99, P < 0.001). Kaplan-Meier analysis revealed no significant differences in OS for patients harboring at least one del allele of rs33989964 compared with CA/CA homozygotes (log-rank test, P = 0.17).

Conclusion

While the SOCS-1 -1478CA > del polymorphism is significantly associated with the risk of GC in the Turkish population, it does not affect OS.

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Funding

This study did not receive specific funding.

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Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine, Uludag University, 16059, Bursa, Turkey

    Mustafa Hartavi

  2. Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Omer Fatih Olmez & Erdem Cubukcu

  3. Department of Immunology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Barbaros Oral

  4. Department of Gastroenterology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Selim Giray Nak

Authors
  1. Mustafa Hartavi
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  2. Omer Fatih Olmez
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  3. Barbaros Oral
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  4. Erdem Cubukcu
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  5. Selim Giray Nak
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Contributions

Study concept and design: Mustafa Hartavi; Data collection and analysis: Mustafa Hartavi, Ömer Fatih Olmez, Barbaros Oral, Erdem Cubukcu, and Selim Giray Nak; Manuscript drafting: Mustafa Hartavi; Critical revision of the manuscript for important intellectual content: Mustafa Hartavi.,Ömer Fatih Olmez, Barbaros Oral, Erdem Cubukcu, and Selim Giray Nak.

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Correspondence to Mustafa Hartavi.

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Hartavi, M., Olmez, O.F., Oral, B. et al. The SOCS-1 -1478CA/del functional polymorphism (rs33989964) is associated with gastric cancer but is unrelated to overall survival. Mol Biol Rep 50, 3489–3492 (2023). https://doi.org/10.1007/s11033-023-08296-6

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  • DOI: https://doi.org/10.1007/s11033-023-08296-6

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