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Suprabasin: Role in human cancers and other diseases

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Abstract

Suprabasin (SBSN), a gene with unknown function located in q13 region of chromosome 19, was first found to be expressed in the basal layer of the stratified epithelium in mouse and human tissues and was thought to be a potential precursor of keratinized capsules. However, in recent years, significant progress has been made in the study of SBSN in a variety of human diseases. One common theme appears to be the effect of SBSN on tumor progression, such as invasion, metastasis and resistance. However, the function and mechanism of action of SBSN is still elusive. In this study, we reviewed the literature on SBSN in the PubMed database to identify the basic characteristics, biological functions, and roles of SBSN in cancer and other diseases. In particular, we focused on the potential mechanisms of SBSN activity, to improve our understanding of the complex function of this protein and provide a theoretical basis for further research on the role of SBSN in cancer and other diseases.

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Abbreviations

AD:

Atopic dermatitis

CHS:

Contact hypersensitivity

CSF:

Cerebrospinal fluid

ESCC:

Esophageal squamous cell carcinoma

EGF:

Epidermal growth factor

IFN-γ:

Interferon-γ

LSE:

Living skin equivalent

mTEC:

Mouse tumor endothelial cell

MDS:

Myelodysplastic syndrome

MS:

Multiple sclerosis

NSCLC:

Non-small cell lung cancer

NEC:

Normal endothelial cells

NPSLE:

Neuropsychiatric systemic lupus erythematosus

NPH:

Normal pressure hydrocephalus

OSCC:

Oral squamous cell carcinoma

SACC:

Salivary adenoid cystic carcinoma

SBSN :

Suprabasin

SLE:

Systemic lupus erythematosus

SC:

Stratum corneum

TEC:

Tumor endothelial cell

Th2:

T helper 2 cell

WGCNA:

Weighted gene co-expression network analysis

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Acknowledgements

This work was supported by the 345 Talent Project of Shengjing Hospital of China Medical University.

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Authors and Affiliations

  1. Department of General Surgery, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning, China

    Hao Tan, Lidong Wang & Zhen Liu

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  1. Hao Tan
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HT and ZL designed the study. HT performed the literature search and drafted the manuscript. LW participated in language editing. ZL reviewed the manuscript. All authors read and approved the final manuscript.

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Correspondence to Zhen Liu.

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Tan, H., Wang, L. & Liu, Z. Suprabasin: Role in human cancers and other diseases. Mol Biol Rep 49, 1453–1461 (2022). https://doi.org/10.1007/s11033-021-06897-7

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