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A study of gene expression by RNA-seq in patients with prostate cancer and in patients with Parkinson disease: an example of inverse comorbidity

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Abstract

Background

Prostate cancer (PCa) is one of the leading causes of death in Western countries. Environmental and genetic factors play a pivotal role in PCa etiology. Timely identification of the genetic causes is useful for an early diagnosis. Parkinson’s disease (PD) is the most frequent neurodegenerative movement disorder; it is associated with the presence of Lewy bodies and genetic factors are involved in its pathogenesis. Several studies have indicated that the expression of target genes in patients with PD is inversely related to cancer development; this phenomenon has been named “inverse comorbidity”. The present study was undertaken to evaluate whether a genetic dysregulation occurs in opposite directions in patients with PD or PCa.

Methods and results

In the present study, next-generation sequencing transcriptome analysis was used to assess whether a genetic dysregulation in opposite directions occurs in patients with PD or PCa. The genes SLC30A1, ADO, SRGAP2C, and TBC1D12 resulted up-regulated in patients with PD compared to healthy donors as controls and down-regulated in patients with PCa compared with the same control group.

Conclusions

These results support the hypothesis of the presence of inverse comorbidity between PD and PCa.

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Funding

This study was supported by The Italian “5 × 1000” funding.

Author information

Author notes

  1. Raffaele Ferri and Michele Salemi have contributed equally to this work.

Authors and Affiliations

  1. Urology Unit, Cannizzaro Hospital, Catania, Italy

    Pietro Pepe, Ludovica Pepe & Michele Pennisi

  2. Pathology Unit, Cannizzaro Hospital, Catania, Italy

    Simona Vatrano & Filippo Fraggetta

  3. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

    Rossella Cannarella & Aldo E. Calogero

  4. Genomix4Life S.r.l, Baronissi, SA, Italy

    Giovanna Marchese & Maria Ravo

  5. Oasi Research Institute-IRCCS, Troina, EN, Italy

    Corrado Romano, Raffaele Ferri & Michele Salemi

Authors
  1. Pietro Pepe
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  2. Simona Vatrano
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  3. Rossella Cannarella
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  4. Aldo E. Calogero
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  5. Giovanna Marchese
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  7. Filippo Fraggetta
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  8. Ludovica Pepe
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  11. Raffaele Ferri
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Contributions

MS, PP, SV, RC, AEC, GM, MR, FG, LP and RF planned the study. MS, SV, GM, MR, performed experiments and analysed data. All authors edited the manuscript.

Corresponding author

Correspondence to Michele Salemi.

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Conflict of interest

The authors Pietro Pepe, Simona Vatrano, Rossella Cannarella, Aldo E. Calogero, Giovanna Marchese, Maria Ravo, Filippo Fraggetta, Ludovica Pepe, Michele Pennisi, Corrado Romano, Raffaele Ferri and Michele Salemi confirm that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The Ethics Committee of the Oasi Research Institute–IRCCS, Troina (Italy) approved the protocol on June 03, 2017 (2017/05/31/CE-IRCCS-OASI/9).

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All the study participants, or their legal guardians, signed an informed consent to publish.

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Pepe, P., Vatrano, S., Cannarella, R. et al. A study of gene expression by RNA-seq in patients with prostate cancer and in patients with Parkinson disease: an example of inverse comorbidity. Mol Biol Rep 48, 7627–7631 (2021). https://doi.org/10.1007/s11033-021-06723-0

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  • DOI: https://doi.org/10.1007/s11033-021-06723-0

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