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Inflammatory, antioxidant and glycemic status to different mode of high-intensity training in type 2 diabetes mellitus

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Abstract

Background

Exercise has traditionally been used and prescribed as an effective and suitable way to treat type 2 diabetics Mellitus (T2DM). In this regard, we compared inflammatory, antioxidant, and glycemic status to different kinds of high-intensity interval training (strength training, HIIT, and HIIT + ST) in patients with T2DM.

Methods and results

Fifty-nine T2DM patients (age = 45–60 yrs) were randomly divided to strength training (ST) (n = 15), high intensity interval training (HIIT) (n = 16), HIIT + ST (n = 15) or served as control (CON) (n = 13) groups. Experimental groups performed three training sessions/week for 12 weeks. Inflammatory, antioxidant, glycemic factors, and anthropometric parameters were evaluated at baseline and after the 12 weeks of interventions.

Training HIIT groups significantly improved antioxidant factors, lipid profile, and glycemic parameters (P ≤ 0.05). Interleukin 6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) significantly decreased in the three training groups. As a result of training, the overall inflammatory and antioxidant status were improved considerably in all three training groups compared to the CON group (P ≤ 0.05). In addition, there were significant differences in CRP at the follow-up values between ST and CON groups (P ≤ 0.05). Exercise time and TC were significantly improved in HIIT than in the CON group (P ≤ 0.05). The results showed a significant difference between the HIIT + ST group and the CON group in VO2peak (P ≤ 0.05).

Conclusions

Our results showed improvement in inflammatory factors, antioxidants, and glycemic parameters in all training groups regardless of their type. However, for more benefits in T2DM patients, combination exercises can be suggested.

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Authors and Affiliations

  1. Department of Exercise Physiology & Health Science, University of Tehran, Tehran, Iran

    Mostafa Sabouri, Parisa Pournemati & Fatemeh Shabkhiz

  2. Department of Exercise Physiology, Sport Sciences Research Institute, Tehran, Iran

    Elaheh Hatami

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  1. Mostafa Sabouri
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  2. Elaheh Hatami
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  4. Fatemeh Shabkhiz
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Contributions

MS, EH, FS designed the study. PP, MS, and EH collected the data. MS and FS revised the final version of the manuscript. All authors read and approved the manuscript.

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Correspondence to Mostafa Sabouri or Fatemeh Shabkhiz.

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The authors declare no conflict of interest.

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All procedures performed in studies involving human participants were by the ethical standards of the ethical committee of Tehran University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Sabouri, M., Hatami, E., Pournemati, P. et al. Inflammatory, antioxidant and glycemic status to different mode of high-intensity training in type 2 diabetes mellitus. Mol Biol Rep 48, 5291–5304 (2021). https://doi.org/10.1007/s11033-021-06539-y

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