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Relationship between GSTM1 and GSTT1 polymorphisms and HPV infection: a systematic review

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Abstract

Human Papillomavirus (HPV) is the most important risk factor for cervical cancer, although not the only one. The allelic polymorphism of enzymes acting on carcinogen metabolism has shown to influence the risk of both intraepithelial lesions and cervical carcinogenesis. Several studies found an association between GSTM1/GSTT1 null genotypes and risk of cancer. This research aimed to review studies addressing the relationship between GSTT1 and GSTM1 and HPV infection in women, with or without cervical pathologies. A database search was conducted in four databases – PubMed, LILACS, SciELO, and Virtual Health Library – using the following descriptors: Glutathione transferase, HPV, and Genetic polymorphism. In total, we found 319 studies. After screening titles and abstracts, 27 articles were selected for full-text read, among which 20 were excluded and 7 were included in the review. No study has exclusively approached the relationship between the virus and GSTM1/GSTT1 variants. However, studies investigating the association between single nucleotide polymorphisms (SNPs) and cervical lesions or cancer found a probable relationship between them and infections with high-risk oncogenic subtypes. Although inconclusive, GSTT1 null alleles were more common in women with more aggressive HPV than GSTM1.

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Authors and Affiliations

  1. Department of Health Sciences, Programa de Pós-graduação em Ciências Aplicadas à Saúde – PPGCAS, Universidade Estadual do Oeste do Paraná, PR-182 Km 02, Bairro Água Branca, Francisco Beltrão, Paraná, Brazil

    Ana Paula Reolon Bortolli, Valquíria Kulig Vieira, Angela Khetly Lazarotto & Léia Carolina Lucio

  2. Centro Universitário de Pato Branco, UNIDEP, Pato Branco, Paraná, Brazil

    Emi Elaine Stefanski

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  1. Ana Paula Reolon Bortolli
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For transparency we inform that all authors performed the literature search and data analysis, drafted and critically revised the work. Ana Paula Reolon Bortolli and Léia Carolina Lucio had the idea for the article.

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Correspondence to Léia Carolina Lucio.

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Bortolli, A.P.R., Vieira, V.K., Stefanski, E.E. et al. Relationship between GSTM1 and GSTT1 polymorphisms and HPV infection: a systematic review. Mol Biol Rep 48, 6631–6636 (2021). https://doi.org/10.1007/s11033-021-06515-6

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