Abstract
In complex etiopathogenesis of diabetic peripheral neuropathy (DPN), hemostatic dysfunction and subclinical inflammation play a possible role. Fibrinogen is involved in both the hemostatic and inflammatory pathways, so we hypothesize that fibrinogen gene polymorphisms might be associated with DPN. A total of 127 young patients with type 1 diabetes (T1D) (average age, 18.5 ± 4.65 years; average diabetes duration, 14.5 ± 2.26 years) and 90 healthy controls were enrolled into the study. Basic biochemical and coagulation parameters were measured and gene polymorphisms of fibrinogen alpha (rs6050) and beta (rs1800790) were established. DPN was diagnosed in 38 diabetic patients by neurological examination. AA genotype and A allele of rs1800790 polymorphism of fibrinogen beta were associated with increased risk of DPN (odds ratio [OR] 4.537, 95% confidence interval [95CI] 1.14–19.94, p = 0.019 and OR 1.958, 95CI 1.038–3.675, p = 0.029, respectively). No association was found between DPN and rs6050 gene polymorphisms. Plasma fibrinogen concentration significantly correlated with HbA1c (Spearman‘s correlation coefficient [r] = 0.54) and HDL cholesterol (r = − 0.67). A allele and AA genotype of rs1800790 seem to be associated with DPN in young patients with T1D. Further studies are appropriate to elucidate the role of fibrinogen gene polymorphisms in the complex etiology of DPN.
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The datasets generated and analyzed during the study are available from corresponding author on reasonable request.
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This study was funded by Grant VEGA 1/0310/18.
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Study concept and design were contributed by JV, ZK, KM, MK, SS and PB; acquisition of data was contributed by KM and MK; statistical analysis was contributed by MG; analysis and data interpretation were contributed by JV, ZK and PB; drafting of manuscript was contributed by JV and SS; critical revision was contributed by ZK and PB. All authors approved the final version of the article, including the authorship list.
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Vojtková, J., Kolková, Z., Motyková, K. et al. An association between fibrinogen gene polymorphisms and diabetic peripheral neuropathy in young patients with type 1 diabetes. Mol Biol Rep 48, 4397–4404 (2021). https://doi.org/10.1007/s11033-021-06455-1
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DOI: https://doi.org/10.1007/s11033-021-06455-1