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Neuroprotection with Bacopa monnieri–A review of experimental evidence

Abstract

Brahmi or aindri is a popular herb in the vast and rich compendium of herbs of Ayurveda and is botanically identified as Bacopa monnieri Linn. (BM). It is extensively used in Ayurveda and other traditional systems of medicine in the management of neurological psychiatric disorders. BM possess active principles belonging to alkaloids, glycosides, flavonoids, saponins categories. Numerous research have been undertaken across the globe to evaluate the neuroprotective potential of this herb. This review collates and summarises current (as on May 2020) published literature on Brahmi as a neuroprotective in neurological and psychiatric disorders. English language articles from databases PubMed, Scopus and Google scholar were searched using appropriate free keywords and MeSH terms related to the topic. The review demonstrates the neuroprotective potential of the Ayurveda herb Brahmi in several disorders including Alzheimer’s disease, epilepsy, Parkinson’s disease, Huntington’s disease, cerebral ischemia and infarct and neoplasms.

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References

  1. Agnivesha A (2013) agnivesha tantra. In: Trikamaji Acharya Y (ed) charaka samhitha, 2013th edn. Choukhamba surabharati prakashana, Varanasi

    Google Scholar 

  2. Agnivesha A (2008) Chikitsasthana. In: Trikamaji Acharya Y (ed) Charaka samhithawith the Ayurveda Dipika commentary of Chakrapanidatta, 10th. Chaukhambha Surabharati Prakashan, Varanasi, p 738

    Google Scholar 

  3. Aguiar S, Borowski T (2013) Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res 16(4):313–326. https://doi.org/10.1089/rej.2013.1431

    Article  PubMed  PubMed Central  Google Scholar 

  4. Aithal MGS, Rajeswari N (2019) Bacoside A Induced Sub-G0 Arrest and Early Apoptosis in Human Glioblastoma Cell Line U-87 MG through Notch Signaling Pathway. Brain Tumor Research and Treatment 7(1):25–32. https://doi.org/10.14791/btrt.2019.7.e21

    Article  PubMed  PubMed Central  Google Scholar 

  5. Akiyama H (2016) Development of Disease-modifying Therapy for Alzheimer’s Disease. Brain and nerve Shinkei kenkyu no shinpo 68(4):463–472. https://doi.org/10.11477/mf.1416200419

    CAS  Article  PubMed  Google Scholar 

  6. Anbarasi K, Kathirvel G, Vani G, Jayaraman G, Shyamala Devi CS (2006) Cigarette smoking induces heat shock protein 70 kDa expression and apoptosis in rat brain: Modulation by bacoside A. Neuroscience 138(4):1127–1135. https://doi.org/10.1016/j.neuroscience.2005.11.029

    CAS  Article  PubMed  Google Scholar 

  7. Anbarasi K, Vani G, Balakrishna K, Devi CSS (2005) Effect of bacoside A on membrane-bound ATPases in the brain of rats exposed to cigarette smoke. J Biochem Mol Toxicol 19(1):59–65. https://doi.org/10.1002/jbt.20050

    CAS  Article  PubMed  Google Scholar 

  8. Anbarasi K, Vani G, Balakrishna K, Devi CSS (2006) Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats. Life Sci 78(12):1378–1384. https://doi.org/10.1016/j.lfs.2005.07.030

    CAS  Article  PubMed  Google Scholar 

  9. Anbarasi K, Vani G, Devi CSS (2005) Protective effect of bacoside A on cigarette smoking-induced brain mitochondrial dysfunction in rats. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer 24(3):225–234. https://doi.org/10.1615/jenvpathtoxoncol.v24.i3.80

    CAS  Article  Google Scholar 

  10. Asher GN, Gerkin J, Gaynes BN (2017) Complementary Therapies for Mental Health Disorders. Med Clin North Am 101(5):847–864. https://doi.org/10.1016/j.mcna.2017.04.004

    Article  PubMed  Google Scholar 

  11. Ayyathan DMDM, Chandrasekaran R, Thiagarajan K (2015) Neuroprotective effect of Brahmi, an ayurvedic drug against oxidative stress induced by methyl mercury toxicity in rat brain mitochondrial-enriched fractions. Nat Prod Res 29(11):1046–1051. https://doi.org/10.1080/14786419.2014.968153

    CAS  Article  PubMed  Google Scholar 

  12. Monniera B (2004) Alternative Medicine Review. A Journal of Clinical Therapeutic 9(1):79–85

    Google Scholar 

  13. Basu N (1967) Chemical examination of Bacopa monniera, Wettst: Part III Bacoside B. Indian J. Chemistry 5:84–86

    CAS  Google Scholar 

  14. Basu N, Rastogi RP, Dhar ML (1965) Chemical examination of Bacopa monnieri. Part III. Bacoside B Ind J Chem 5:84–86

    Google Scholar 

  15. Bhardwaj P, Jain CK, Mathur A (2018) Comparative evaluation of four triterpenoid glycoside saponins of bacoside A in alleviating sub-cellular oxidative stress of N2a neuroblastoma cells. J Pharm Pharmacol 70(11):1531–1540. https://doi.org/10.1111/jphp.12993

    CAS  Article  PubMed  Google Scholar 

  16. Bhattacharya SK, Kumar A (1999) Effect of Bacopa monnieri on Animal Models of Alzheimer’s disease and Perturbed Central Cholinergic Markers of Cognition in Rats. In: Bhattacharye SK (ed) Molecular Aspects of Asian Medicines. PJD Publications, New York, pp 27–58

    Google Scholar 

  17. Chaudhari KSKS, Tiwari NRNR, Tiwari RRRR, Sharma RSRS (2017) Neurocognitive effect of nootropic drug Brahmi (Bacopa monnieri) in Alzheimer’s disease. Ann Neurosci 24(2):111–122. https://doi.org/10.1159/000475900

    Article  PubMed  PubMed Central  Google Scholar 

  18. Choudhary S, Kumar P, Malik J (2013) Plants and phytochemicals for Huntington′s disease. Pharmacognosy Reviews 7(14):81–91. https://doi.org/10.4103/0973-7847.120505

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  19. Cui Y-M, Ao M-Z, Li W, Yu L-J (2008) Effect of glabridin from Glycyrrhiza glabra on learning and memory in mice. Planta Med 74(4):377–380. https://doi.org/10.1055/s-2008-1034319

    CAS  Article  PubMed  Google Scholar 

  20. Das A, Shanker G, Nath C, Pal R, Singh S, Singh H (2002) A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba: anticholinesterase and cognitive enhancing activities. Pharmacol Biochem Behav 73(4):893–900. https://doi.org/10.1016/s0091-3057(02)00940-1

    CAS  Article  PubMed  Google Scholar 

  21. Deepak M, Amit A (2013) ’Bacoside B’–the need remains for establishing identity. Fitoterapia 87:7–10. https://doi.org/10.1016/j.fitote.2013.03.011

    CAS  Article  PubMed  Google Scholar 

  22. Dethe S, Deepak M, Agarwal A (2016) Elucidation of molecular mechanism(s) of cognition enhancing activity of Bacomind® : A standardized extract of bacopa monnieri. Pharmacognosy Magazine 12(47):S482–S487. https://doi.org/10.4103/0973-1296.191464

    Article  PubMed  PubMed Central  Google Scholar 

  23. Dhanasekaran M, Tharakan B, Holcomb LA, Hitt AR, Young KA, Manyam BV (2007) Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera. Phytotherapy Research : PTR 21(10):965–969. https://doi.org/10.1002/ptr.2195

    CAS  Article  PubMed  Google Scholar 

  24. Dubey T, Chinnathambi S (2019) Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer’s disease. Arch Biochem Biophys 676:108153. https://doi.org/10.1016/j.abb.2019.108153

    CAS  Article  PubMed  Google Scholar 

  25. Dutta T, B. U. P. (1963) Terpenoids: Part II-Isolation of new triterpene saponin, monnierin, from Bacopa monniera Wettst. Ind J Chem 1:400–408

    Google Scholar 

  26. Dwivedi S, Nagarajan R, Hanif K, Siddiqui HH, Nath C, Shukla R (2013) Standardized Extract of Bacopa monniera Attenuates Okadaic Acid Induced Memory Dysfunction in Rats: Effect on Nrf2 Pathway. Evidence-Based Complementary and Alternative Medicine : ECAM 2013:294501. https://doi.org/10.1155/2013/294501

    Article  Google Scholar 

  27. Ghosh S, Banerjee S, Sil PC (2015) The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 83:111–124. https://doi.org/10.1016/j.fct.2015.05.022

    CAS  Article  Google Scholar 

  28. Golechha M, Bhatia J, Ojha S, Arya DS (2011) Hydroalcoholic extract of Emblica officinalis protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory, and neuroprotective intervention. Pharm Biol 49(11):1128–1136. https://doi.org/10.3109/13880209.2011.571264

    Article  PubMed  Google Scholar 

  29. Goswami S, Saoji A, Kumar N, Thawani V, Tiwari M (2011) Effect of Bacopa monnieri on Cognitive functions in Alzheimer ’ s disease patients Effect of Bacopa monnieri on Cognitive functions in Alzheimer ’ s disease patients 3(May):285–293

    Google Scholar 

  30. Das G (2007) Jwarachikitsa prakaranam. In: Mishra B (ed) Bhaishajya ratnavali withVidyiotini Hindi commentary of Ambikadattashastri. Chaukhambha Prakashan, Varanasi, p 162

    Google Scholar 

  31. Hegde D, Bhargav PH, Bhargav H, Babu H, Varsha KA, Raghuram N (2020) Feasibility and Pilot Efficacy Testing of Integrated Yoga and Shirodhara (Ayurvedic Oil-Dripping) Intervention on Clinical Symptoms, Cognitive Functions and Sleep Quality of Adults with Anxiety Disorder. Int J Yoga 13(1):32–41. https://doi.org/10.4103/ijoy.IJOY_44_19

    Article  PubMed  PubMed Central  Google Scholar 

  32. Hosamani R, Krishna G, Muralidhara. (2016) Standardized Bacopa monnieri extract ameliorates acute paraquat-induced oxidative stress, and neurotoxicity in prepubertal mice brain. Nutr Neurosci 19(10):434–446. https://doi.org/10.1179/1476830514Y.0000000149

    Article  PubMed  Google Scholar 

  33. Hosamani R, Muralidhara. (2009) Neuroprotective efficacy of Bacopa monnieri against rotenone induced oxidative stress and neurotoxicity in Drosophila melanogaster. Neurotoxicology 30(6):977–985. https://doi.org/10.1016/j.neuro.2009.08.012

    CAS  Article  PubMed  Google Scholar 

  34. Ijaz N, Rioux J, Elder C, Weeks J (2019) Whole Systems Research Methods in Health Care: A Scoping Review. Journal of Alternative and Complementary Medicine (New York, N.Y.) 25(S1):S21–S51. https://doi.org/10.1089/acm.2018.0499

    Article  Google Scholar 

  35. Jadiya P, Khan A, Sammi SR, Kaur S, Mir SS, Nazir A (2011) Anti-Parkinsonian effects of Bacopa monnieri: Insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson’s disease. Biochem Biophys Res Commun 413(4):605–610. https://doi.org/10.1016/j.bbrc.2011.09.010

    CAS  Article  PubMed  Google Scholar 

  36. Jaideep SS, Nagaraja D, Pal PK, Sudhakara D, Talakad SN (2014) Modulation of Cardiac Autonomic Dysfunction in Ischemic Stroke following Ayurveda (Indian System of Medicine) Treatment. Evidence-Based Complementary and Alternative Medicine: ECAM 2014:634695. https://doi.org/10.1155/2014/634695

    Article  Google Scholar 

  37. Jebasingh D, Devavaram Jackson D, Venkataraman S, Adeghate E, Starling Emerald B (2014) The protective effects of Cyperus rotundus on behavior and cognitive function in a rat model of hypoxia injury. Pharm Biol 52(12):1558–1569. https://doi.org/10.3109/13880209.2014.908395

    CAS  Article  PubMed  Google Scholar 

  38. Jorm A (2002) Prospects for the prevention of dementia. Australas J Ageing 21:9–13

    Article  Google Scholar 

  39. Kadri Y, Nciri R, Brahmi N, Saidi S, Harrath AH, Alwasel S, Allagui MS (2018) Protective effects of Curcuma longa against neurobehavioral and neurochemical damage caused by cerium chloride in mice. Environ Sci Pollut Res 25(20):19555–19565. https://doi.org/10.1007/s11356-018-2151-7

    CAS  Article  Google Scholar 

  40. Kamkaew N, Norman Scholfield C, Ingkaninan K, Taepavarapruk N, Chootip K (2013) Bacopa monnieri increases cerebral blood flow in rat independent of blood pressure. Phytother Res 27(1):135–138. https://doi.org/10.1002/ptr.4685

    Article  PubMed  Google Scholar 

  41. Karim N, Abdelhalim H, Gavande N, Khan I, Khan H (2018) Natural Products as an Emerging Therapeutic Alternative in the Treatment of Neurological Disorders. Evidence-Based Complementary and Alternative Medicine : ECAM 2018:3056847. https://doi.org/10.1155/2018/3056847

    Article  Google Scholar 

  42. Khan AV, Ahmed QU, Shukla I, Khan AA (2010) Antibacterial efficacy of Bacopa minnieri leaf extracts against pathogenic bacteria. Asian Biomedicine 4(4):651–655. https://doi.org/10.2478/abm-2010-0084

    Article  Google Scholar 

  43. Khan R, Krishnakumar A, Paulose CS (2008) Decreased glutamate receptor binding and NMDA R1 gene expression in hippocampus of pilocarpine-induced epileptic rats: neuroprotective role of Bacopa monnieri extract. Epilepsy & Behavior : E&B 12(1):54–60. https://doi.org/10.1016/j.yebeh.2007.09.021

    Article  Google Scholar 

  44. Kishore K, Singh M (2005) Effect of bacosides, alcoholic extract of Bacopa monniera Linn. (brahmi), on experimental amnesia in mice. Indian J Exp Biol 43(7):640–645

    PubMed  Google Scholar 

  45. Kishore RK, Abhishekh HA, Udupa K, Thirthalli J, Lavekar GS, Gangadhar BN, Sathyaprabha TN (2014) Evaluation of the influence of ayurvedic formulation (Ayushman-15) on psychopathology, heart rate variability and stress hormonal level in major depression (Vishada). Asia J Psychiatr 12:100–107. https://doi.org/10.1016/j.ajp.2014.07.002

    Article  Google Scholar 

  46. Kizhakke PA, Olakkaran S, Antony A, Tilagul KS, Hunasanahally PG (2019) Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAPτ) induced neurotoxicity in Alzheimer’s disease Drosophila model. J Chem Neuroanat 95:115–122. https://doi.org/10.1016/j.jchemneu.2017.10.002

    Article  Google Scholar 

  47. Koithan M, Bell IR, Niemeyer K, Pincus D (2012) A Complex Systems Science Perspective for Whole Systems of Complementary and Alternative Medicine Research. Complementary Medicine Research 19(Suppl. 1):7–14. https://doi.org/10.1159/000335181

    Article  Google Scholar 

  48. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Norman Scholfield C (2014) Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 151(1):528–535. https://doi.org/10.1016/j.jep.2013.11.008

    Article  PubMed  Google Scholar 

  49. Kothandapani A, Ganapathy V, Balakrishna K, Devi C (2005) Creatine kinase isoenzyme patterns upon chronic exposure to cigarette smoke: Protective effect of Bacoside A. Vascul Pharmacol 42:57–61. https://doi.org/10.1016/j.vph.2005.01.003

    CAS  Article  Google Scholar 

  50. Krishna G, Hosamani R, Muralidhara. (2019) Bacopa monnieri Supplements Offset Paraquat-Induced Behavioral Phenotype and Brain Oxidative Pathways in Mice. Cent Nerv Syst Agents Med Chem 19(1):57–66. https://doi.org/10.2174/1871524919666190115125900

    CAS  Article  PubMed  Google Scholar 

  51. Krishnakumar A, Nandhu MS, Paulose CS (2009) Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: antagonism by Bacopa monnieri. Epilepsy & Behavior : E&B 16(2):225–230. https://doi.org/10.1016/j.yebeh.2009.07.031

    Article  Google Scholar 

  52. Kuboyama T, Tohda C, Komatsu K (2014) Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases. Biol Pharm Bull 37(6):892–897. https://doi.org/10.1248/bpb.b14-00022

    CAS  Article  PubMed  Google Scholar 

  53. Kumar S, Mondal AC (2016) Neuroprotective, Neurotrophic and Anti-oxidative Role of Bacopa monnieri on CUS Induced Model of Depression in Rat. Neurochem Res 41(11):3083–3094. https://doi.org/10.1007/s11064-016-2029-3

    CAS  Article  PubMed  Google Scholar 

  54. Limpeanchob N, Jaipan S, Rattanakaruna S, Phrompittayarat W, Ingkaninan K (2008) Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture. J Ethnopharmacol 120(1):112–117. https://doi.org/10.1016/j.jep.2008.07.039

    Article  PubMed  Google Scholar 

  55. Liu X, Yue R, Zhang J, Shan L, Wang R, Zhang W (2013) Neuroprotective effects of bacopaside I in ischemic brain injury. Restor Neurol Neurosci 31(2):109–123. https://doi.org/10.3233/RNN-120228

    CAS  Article  PubMed  Google Scholar 

  56. Łojewski M, Pomierny B, Muszyńska B, Krzyżanowska W, Budziszewska B, Szewczyk A (2016) Protective Effects of Bacopa Monnieri on Hydrogen Peroxide and Staurosporine: Induced Damage of Human Neuroblastoma SH-SY5Y Cells. Planta Med 82(3):205–210. https://doi.org/10.1055/s-0035-1558166

    CAS  Article  PubMed  Google Scholar 

  57. Malhotra CL, Das PK (1959) Pharmacological studies of Herpestis monniera, Linn., (Brahmi). Indian J Med Res 47(3):294–305

    CAS  PubMed  Google Scholar 

  58. Mathew J, Balakrishnan S, Antony S, Abraham PM, Paulose CS (2012) Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. J Biomed Sci 19(1):25. https://doi.org/10.1186/1423-0127-19-25

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  59. Mathew J, Gangadharan G, Kuruvilla KP, Paulose CS (2011) Behavioral deficit and decreased GABA receptor functional regulation in the hippocampus of epileptic rats: effect of Bacopa monnieri. Neurochem Res 36(1):7–16. https://doi.org/10.1007/s11064-010-0253-9

    CAS  Article  PubMed  Google Scholar 

  60. Mathew J, Paul J, Nandhu MS, Paulose CS (2010) Bacopa monnieri and Bacoside-A for ameliorating epilepsy associated behavioral deficits. Fitoterapia 81(5):315–322. https://doi.org/10.1016/j.fitote.2009.11.005

    Article  PubMed  Google Scholar 

  61. Mathew J, Peeyush Kumar T, Khan RS, Paulose CS (2010) Behavioral deficit and decreased GABA receptor functional regulation in the cerebellum of epileptic rats: effect of Bacopa monnieri and bacoside A. Epilepsy & Behavior : E&B 17(4):441–447. https://doi.org/10.1016/j.yebeh.2010.01.012

    Article  Google Scholar 

  62. Mathur D, Goyal K, Koul V, Anand A (2016) The Molecular Links of Re-Emerging Therapy: A Review of Evidence of Brahmi (Bacopa monniera). Front Pharmacol. https://doi.org/10.3389/fphar.2016.00044

    Article  PubMed  PubMed Central  Google Scholar 

  63. Mishra AAKAAK, Mishra AAKAAK, Jha S (2018) Effect of traditional medicine brahmi vati and bacoside A-rich fraction of Bacopa monnieri on acute pentylenetetrzole-induced seizures, amphetamine-induced model of schizophrenia, and scopolamine-induced memory loss in laboratory animals. Epilepsy & Behavior : E&B 80:144–151. https://doi.org/10.1016/j.yebeh.2017.12.040

    Article  Google Scholar 

  64. Nayak VS, Kumar N, D’Souza AS, Nayak SS, Cheruku SP, Pai KSR (2017) The effects of Mucuna pruriens extract on histopathological and biochemical features in the rat model of ischemia. NeuroReport 28(18):1195–1201. https://doi.org/10.1097/WNR.0000000000000888

    Article  PubMed  Google Scholar 

  65. Nellore J, Pauline C, Amarnath K (2013) Bacopa monnieri Phytochemicals Mediated Synthesis of Platinum Nanoparticles and Its Neurorescue Effect on 1-Methyl 4-Phenyl 1,2,3,6 Tetrahydropyridine-Induced Experimental Parkinsonism in Zebrafish. Journal of Neurodegenerative Diseases 2013:972391. https://doi.org/10.1155/2013/972391

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  66. Nobili F, Vitali P, Canfora M, Girtler N, De Leo C, Mariani G, Rodriguez G (2002) Effects of long-term Donepezil therapy on rCBF of Alzheimer’s patients. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology 113(8):1241–1248. https://doi.org/10.1016/s1388-2457(02)00110-4

    CAS  Article  Google Scholar 

  67. Pandey R, Gupta S, Tandon S, Wolkenhauer O, Vera J, Gupta SK (2010) Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans. Seizure 19(7):439–442. https://doi.org/10.1016/j.seizure.2010.06.005

    Article  PubMed  Google Scholar 

  68. Pandey SP, Singh HK, Prasad S (2015) Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by Bacopa monnieri Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice. PLoS ONE 10(7):e0131862. https://doi.org/10.1371/journal.pone.0131862

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  69. Pase MP, Kean J, Sarris J, Neale C, Scholey AB, Stough C (2012) The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. Journal of Alternative and Complementary Medicine (New York, N.Y.) 18(7):647–652. https://doi.org/10.1089/acm.2011.0367

    Article  Google Scholar 

  70. Pathak-Gandhi N, Vaidya ADB (2017) Management of Parkinson’s disease in ayurveda: medicinal plants and adjuvant measures. J Ethnopharmacol 197:46–51. https://doi.org/10.1016/j.jep.2016.08.020

    Article  PubMed  Google Scholar 

  71. Perrig WJ, Perrig P (1997) The relation between antioxidants and memory performance in the old and very old. J Am Geriatr Soc 45:718–724

    CAS  Article  Google Scholar 

  72. Piyabhan P, Wetchateng T (2014) Neuroprotective effects of Bacopa monnieri (Brahmi) on novel object recognition and NMDAR1 immunodensity in the prefrontal cortex, striatum and hippocampus of sub-chronic phencyclidine rat model of schizophrenia. Journal of the Medical Association of Thailand Chotmaihet Thangphaet 97(Suppl 8):S50–S55

    PubMed  Google Scholar 

  73. Prasad S, Kashyap RS, Deopujari JY, Purohit HJ, Taori GM, Daginawala HF (2007) Effect of Fagonia Arabica (Dhamasa) on in vitro thrombolysis. BMC Complement Altern Med 7:36. https://doi.org/10.1186/1472-6882-7-36

    Article  PubMed  PubMed Central  Google Scholar 

  74. Raghav S, Singh H, Dalal PK, Srivastava JS, Asthana OP (2006) Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian Journal of Psychiatry 48(4):238–242. https://doi.org/10.4103/0019-5545.31555

    Article  PubMed  PubMed Central  Google Scholar 

  75. Rai R, Singh HK, Prasad S (2015) A Special Extract of Bacopa monnieri (CDRI-08) Restores Learning and Memory by Upregulating Expression of the NMDA Receptor Subunit GluN2B in the Brain of Scopolamine-Induced Amnesic Mice. Evidence-Based Complementary and Alternative Medicine : ECAM 2015:254303. https://doi.org/10.1155/2015/254303

    Article  Google Scholar 

  76. Rastogi M, Ojha RPRPRP, Prabu PCC, Devi BPP, Agrawal A, Dubey GPP (2012) Prevention of age-associated neurodegeneration and promotion of healthy brain ageing in female wistar rats by long term use of bacosides. Biogerontology 13(2):183–195. https://doi.org/10.1007/s10522-011-9367-y

    CAS  Article  PubMed  Google Scholar 

  77. Rastogi S, Pal R, Kulshreshtha D (1994) Bacoside A3—a triterpenoid saponin from Bacopa monniera. Phytochemistry 36:133–137

    CAS  Article  Google Scholar 

  78. Rauf K, Subhan F, Al-Othman AM, Khan I, Zarrelli A, Shah MR (2013) Preclinical profile of bacopasides from Bacopa monnieri (BM) as an emerging class of therapeutics for management of chronic pains. Curr Med Chem 20(8):1028–1037

    CAS  PubMed  Google Scholar 

  79. Rehni AK, Pantlya HS, Shri R, Singh M (2007) Effect of chlorophyll and aqueous extracts of Bacopa monniera and Valeriana wallichii on ischaemia and reperfusion-induced cerebral injury in mice. Indian J Exp Biol 45(9):764–769

    PubMed  Google Scholar 

  80. Munshi R, Supriya Bhalerao TN (2016) Evaluation of the efficacy of Brahmi ghrita in scopolamine induced amnesia in rats using Cook’s pole apparatus. International Journal of Basic and Clinical Pharmacology. https://doi.org/10.18203/2319-2003.ijbcp20161529

    Article  Google Scholar 

  81. Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J (2002) Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 27(2):279–281. https://doi.org/10.1016/S0893-133X(01)00419-5

    Article  Google Scholar 

  82. Saini N, Singh D, Sandhir R (2012) Neuroprotective effects of Bacopa monnieri in experimental model of dementia. Neurochem Res 37(9):1928–1937. https://doi.org/10.1007/s11064-012-0811-4

    CAS  Article  PubMed  Google Scholar 

  83. Saraf MK, Prabhakar S, Pandhi P, Anand A (2008) Bacopa monniera ameliorates amnesic effects of diazepam qualifying behavioral–molecular partitioning. Neuroscience 155(2):476–484. https://doi.org/10.1016/j.neuroscience.2008.05.043

    CAS  Article  PubMed  Google Scholar 

  84. Sharma J, Gairola S, Gaur RD, Painuli RM, Siddiqi TO (2013) Ethnomedicinal plants used for treating epilepsy by indigenous communities of sub-Himalayan region of Uttarakhand India. J Ethnopharmacol 150(1):353–370. https://doi.org/10.1016/j.jep.2013.08.052

    Article  PubMed  Google Scholar 

  85. Saraf MK, Prabhakar S, Anand A (2010) Neuroprotective effect of Bacopa monniera on ischemia induced brain injury. Pharmacol Biochem Behav 97(2):192–197. https://doi.org/10.1016/j.pbb.2010.07.017

    CAS  Article  PubMed  Google Scholar 

  86. Scheltens P, Blennow K, Breteler MMB, de Strooper B, Frisoni GB, Salloway S, Van der Flier WM (2016) Alzheimer’s disease. Lancet (London, England) 388(10043):505–517. https://doi.org/10.1016/S0140-6736(15)01124-1

    CAS  Article  Google Scholar 

  87. Shahid M, Subhan F, Ali G, Ullah I, Alam J, Ullah S, Rauf K (2017) Neuroprotective effect of Bacopa monnieri against morphine-induced histopathological changes in the cerebellum of rats. Pak J Pharm Sci 30(6):2067–2074

    CAS  PubMed  Google Scholar 

  88. Sharangadhara A (2000) Madhyamakhanda, kalka adhikara. In: Sharangadhara A (ed) Sharangadhara samhitha. Varanasi, Krishnadas academy, p 398

    Google Scholar 

  89. Shinomol G, Muralidhara M, Bharath MMS (2011) Exploring the Role of “Brahmi” (Bacopa monnieri and Centella asiatica) in Brain Function and Therapy. Recent Pat Endocr, Metab Immune Drug Discovery 5(1):33–49. https://doi.org/10.2174/187221411794351833

    CAS  Article  Google Scholar 

  90. Singh A, Singh SK (2009) Evaluation of antifertility potential of Brahmi in male mouse. Contraception 79(1):71–79. https://doi.org/10.1016/j.contraception.2008.07.023

    CAS  Article  PubMed  Google Scholar 

  91. Singh B, Pandey S, Verma R, Ansari JA, Mahdi AA (2016) Comparative evaluation of extract of Bacopa monnieri and Mucuna pruriens as neuroprotectant in MPTP model of Parkinson’s disease. Indian J Exp Biol 54(11):758–766

    PubMed  Google Scholar 

  92. Singh B, Pandey S, Yadav SK, Verma R, Singh SP, Mahdi AA (2017) Role of ethanolic extract of Bacopa monnieri against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mice model via inhibition of apoptotic pathways of dopaminergic neurons. Brain Res Bull 135:120–128. https://doi.org/10.1016/j.brainresbull.2017.10.007

    Article  PubMed  Google Scholar 

  93. Singh HK, Dhawan BN (1982) Effect of Bacopa monniera Linn. (brahmi) extract on avoidance responses in rat. J Ethnopharmacol 5(2):205–214. https://doi.org/10.1016/0378-8741(82)90044-7

    CAS  Article  PubMed  Google Scholar 

  94. Singh HK, Rastogi RP, Srimal RC, Dhawan BN (1998) Effect of bacosides A and B on avoidance responses in rats. Phytother Res 2:70–75

    Article  Google Scholar 

  95. SinghDhawan HKBN (1997) Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J Pharmaco 29:359–365

    Google Scholar 

  96. Singh M, Murthy V, Ramassamy C (2013) Neuroprotective mechanisms of the standardized extract of Bacopa monniera in a paraquat/diquat-mediated acute toxicity. Neurochem Int 62(5):530–539. https://doi.org/10.1016/j.neuint.2013.01.030

    CAS  Article  PubMed  Google Scholar 

  97. Singh R, Ramakrishna R, Bhateria M, Bhatta RS (2014) In vitro evaluation of Bacopa monniera extract and individual constituents on human recombinant monoamine oxidase enzymes. Phytotherapy Research : PTR 28(9):1419–1422. https://doi.org/10.1002/ptr.5116

    CAS  Article  PubMed  Google Scholar 

  98. Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S (2009) Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. Neuro India 57(2):166–171. https://doi.org/10.4103/0028-3886.51286

    CAS  Article  Google Scholar 

  99. Srivastav S, Fatima M, Mondal AC (2018) Bacopa monnieri alleviates paraquat induced toxicity in Drosophila by inhibiting jnk mediated apoptosis through improved mitochondrial function and redox stabilization. Neurochem Int 121:98–107. https://doi.org/10.1016/j.neuint.2018.10.001

    CAS  Article  PubMed  Google Scholar 

  100. Srivastava P, Raut HN, Puntambekar HM, Desai AC (2012) Stability studies of crude plant material of Bacopa monnieri and quantitative determination of bacopaside I and bacoside A by HPLC. Phytochemical Analysis : PCA 23(5):502–507. https://doi.org/10.1002/pca.2347

    CAS  Article  PubMed  Google Scholar 

  101. Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ (2001) The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 156(4):481–484. https://doi.org/10.1007/s002130100815

    CAS  Article  PubMed  Google Scholar 

  102. Sumathy T, Govindasamy S, Balakrishna K, Veluchamy G (2002) Protective role of Bacopa monniera on morphine-induced brain mitochondrial enzyme activity in rats. Fitoterapia 73(5):381–385. https://doi.org/10.1016/s0367-326x(02)00114-4

    CAS  Article  PubMed  Google Scholar 

  103. Tubaki BR, Chandrashekar CR, Sudhakar D, Prabha TNS, Lavekar GS, Kutty BM (2012) Clinical efficacy of manasamitra vataka (an ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: A randomized controlled study. J Alter Complement Med 18(6):612–621. https://doi.org/10.1089/acm.2010.0778

    Article  Google Scholar 

  104. Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K (2010) Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model. J Ethnopharmacol 127(1):26–31. https://doi.org/10.1016/j.jep.2009.09.056

    Article  PubMed  Google Scholar 

  105. Vagbhata A (2007) Uttarasthana, 6th chapter. In: Kunte AM (ed) Ashtanga Hridaya with Sarvanga sundara and ayurveda rasayana commentary. Chaukhambha Surabharati Prakashan, Varanasi, p 956

    Google Scholar 

  106. Vajda FJE (2002) Neuroprotection and neurodegenerative disease. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 9(1):4–8. https://doi.org/10.1054/jocn.2001.1027

    Article  Google Scholar 

  107. Vani G, Anbarasi K, Shyamaladevi CS (2015) Bacoside A: Role in Cigarette Smoking Induced Changes in Brain. Evidence-Based Complementary and Alternative Medicine : ECAM 2015:286137. https://doi.org/10.1155/2015/286137

    CAS  Article  Google Scholar 

  108. Vasudevan M, Parle M (2007) Memory enhancing activity of Anwala churna (Emblica officinalis Gaertn.): an Ayurvedic preparation. Physiol Behav 91(1):46–54. https://doi.org/10.1016/j.physbeh.2007.01.016

    CAS  Article  PubMed  Google Scholar 

  109. Ven Murthy MRR, Ranjekar PKPK, Ramassamy C, Deshpande M, Murthy MRV, Ranjekar PKPK, Deshpande M (2010) Scientific Basis for the Use of Indian Ayurvedic Medicinal Plants in the Treatment of Neurodegenerative Disorders: 1. Ashwagandha. Cent Nerv Syst Agents Med Chem 10(3):238–246. https://doi.org/10.2174/1871524911006030238

    CAS  Article  PubMed  Google Scholar 

  110. Verma P, Singh P, Gandhi BS (2014) Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice. Iranian Journal of Basic Medical Sciences 17(4):307–311

    PubMed  PubMed Central  Google Scholar 

  111. Vohora D, Pal SN, Pillai KK (2000) Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant. J Ethnopharmacol 71(3):383–390. https://doi.org/10.1016/s0378-8741(99)00213-5

    CAS  Article  PubMed  Google Scholar 

  112. Wells RE, Baute V, Wahbeh H (2017) Complementary and Integrative Medicine for Neurologic Conditions. Med Clin North Am 101(5):881–893. https://doi.org/10.1016/j.mcna.2017.04.006

    Article  PubMed  PubMed Central  Google Scholar 

  113. Agnivesha T, Trikamji Acharya Y (2008) Chikitsasthana, Charaka Samhita with the Ayurveda Dipika commentary of Chakrapanidatta, 10th chapter. Varanasi, Chaukhambha Surabharati Prakashan, p 738

    Google Scholar 

  114. Agnivesha T, Samhita C (2013) ‘Ayurveda Deepika’ commentary by chakrapanidatta, Chapter 25. Choukhamba surabharati prakashana, Varanasi

    Google Scholar 

  115. Vagbhata A, Moreshwara Kunte A (2007) Uttarasthana, Ashtanga Hridaya with Sarvanga sundara and ayurveda rasayana commentary, 6th chapter. Varanasi, Chaukhambha Surabharati Prakashan, p 956

    Google Scholar 

  116. Das G, Mishra B (2007) Jwarachikitsa prakaranam, with the Vidyitinni Hindi commentary of Ambikadattashastri, 5th chapter. Varanasi, Chaukhambha Prakashan, p 162

    Google Scholar 

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Shalini, V.T., Neelakanta, S.J. & Sriranjini, J.S. Neuroprotection with Bacopa monnieri–A review of experimental evidence. Mol Biol Rep 48, 2653–2668 (2021). https://doi.org/10.1007/s11033-021-06236-w

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Keywords

  • Brahmi
  • Bacopa monnieri
  • Neuroprotection
  • Neurological disorders
  • Psychiatric disorders