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Long noncoding RNAs as a piece of polycystic ovary syndrome puzzle

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Abstract

Polycystic ovary syndrome (PCOS) is an endocrine disorder and affects 5–10% of reproductive-age women. Chronic anovulation, polycystic ovaries, and hyperandrogenism are the important features of this syndrome. Furthermore, hyperinsulinemia and central obesity are frequent in PCOS women. In recent years, noncoding RNAs detection provided new ideas to explain the etiology of female reproductive disorders. Long noncoding RNAs (lncRNAs) as a subset of noncoding RNAs are associated with the pathogenesis of manifold reproductive-related disorders. Various investigations emphasized the potential involvement of lncRNAs in PCOS development. Therefore, in this paper, we will summarize the function of numerous lncRNAs in the apoptosis and proliferation of granulosa cells (GCs), insulin resistance (IR), and steroidogenesis in PCOS.

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Authors and Affiliations

  1. Student Research Committee, Babol University of Medical Sciences, Babol, Iran

    Maryam Abolghasemi

  2. Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandaran, Iran

    Maryam Abolghasemi & Soleiman Mahjoub

  3. Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Ganjafrooz Avenue, Babol, Islamic Republic of Iran

    Maryam Abolghasemi & Soleiman Mahjoub

Authors
  1. Maryam Abolghasemi
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  2. Soleiman Mahjoub
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MA and SM designed the mini-review. MA wrote the manuscript. SM participated in the text editing of the manuscript and prepared the table of manuscript. All authors read the manuscript.

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Correspondence to Soleiman Mahjoub.

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Abolghasemi, M., Mahjoub, S. Long noncoding RNAs as a piece of polycystic ovary syndrome puzzle. Mol Biol Rep 48, 3845–3851 (2021). https://doi.org/10.1007/s11033-021-06196-1

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