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Acute oral treatment with resveratrol and Lactococcus Lactis Subsp. Lactis decrease body weight and improve liver proinflammatory markers in C57BL/6 mice

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Abstract

The present study aimed to evaluate the effects of resveratrol, a nutraceutical polyphenol, and Lactococcus lactis (bacteria probiotic), on metabolic parameters and hepatic proinflammatory markers expression. C57BL/6 mice were divided into 4 groups: Standard (ST), Lactococcus lactis (LL), Resveratrol (RSV), and Lactococcus lactis plus resveratrol (LL + RSV). Lactococcus lactis and resveratrol were administered by orogastric gavage. Blood parameters were assessed (total cholesterol, triglycerides, ALT and AST). IL-6 mRNA expression was evaluated by Real-time PCR and TNF-α protein expression was assessed by immunohistochemistry. The main findings showed that resveratrol and Lactococcus lactis association decreased body weight, aspartate aminotransferase and total cholesterol levels. LL and LL + RSV decreased triglycerides levels and IL-6 and TNF-α expression. These results open a perspective of using resveratrol and Lactococcus lactis to improve metabolic parameters and Lactococcus lactis in preventing inflammation and the hepatic diseases development.

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Funding

The present work was supported, in part, by Grants from Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG—Brazil), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq—Brazil) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Brazil).

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Authors and Affiliations

  1. Laboratory of Health Science, Postgraduate Program in Health Science, Department of Health Science, Hospital Universitário Clemente Faria, Universidade Estadual de Montes Claros (Unimontes), Avenida Cula Mangabeira, 562 - Santo Expedito, Montes Claros, Minas Gerais, CEP 39401-001, Brazil

    Keila Lopes Mendes, Deborah de Farias Lelis, Daniela Fernanda de Freitas, André Luiz Sena Guimarães, Janaína Ribeiro Oliveira, Mariléia Chaves Andrade, Sérgio Avelino Mota Nobre & Sérgio Henrique Sousa Santos

  2. Instituto Federal de Minas Gerais (IFMG), São João Evangelista, Minas Gerais, Brazil

    Keila Lopes Mendes

  3. Hospital Universitário Clemente de Faria, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil

    Luiz Henrique da Silveira

  4. Institudo de Ciências Agrárias (ICA), Food Engineering Department, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil

    Sérgio Henrique Sousa Santos

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  1. Keila Lopes Mendes
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This study was approved by the Ethics Committee of Experimentation and Animal Welfare of Unimontes, Montes Claros, Brazil (process nº 082/2014).

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Mendes, K.L., Lelis, D.F., de Freitas, D.F. et al. Acute oral treatment with resveratrol and Lactococcus Lactis Subsp. Lactis decrease body weight and improve liver proinflammatory markers in C57BL/6 mice. Mol Biol Rep 48, 1725–1734 (2021). https://doi.org/10.1007/s11033-021-06190-7

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