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A review on EBV encoded and EBV-induced host microRNAs expression profile in different lymphoma types

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Abstract

Previous literature supports the variations in microRNAs expression levels among lymphoma patients due to EBV infection. These alterations can be observed in both EBV-encoded-microRNAs and EBV-induced cellular microRNAs. Moreover, changes in the microRNA profile could be significant in disease progression. This study aimed to assess published literature to obtain a microRNA profile for both EBV-encoded microRNAs and EBV-induced cellular microRNAs among lymphoma patients. We searched common available electronic databases by using relevant keywords. The result demonstrated that EBV infection could alter the microRNA expression levels among lymphoma patients. In Burkitt lymphoma, hsa-miR197 and miR510 were most frequently assessed human micro RNAs. Also, miR-BART6-3P and miR-BART17-5P were the most frequent viral micro RNAs in Burkitt lymphoma. Other human important micro RNAs were hsa-miR155 (in Diffuse large B cell lymphoma (DLBCL)), hsa-miR145 (in Nasal natural killer T cell lymphoma (NNKTCL)), miR-96, miR-128a, miR-128b, miR-129, and miR-205 (in Classic Hodgkin lymphoma (CHL)), miR-21, miR-142-3P, miR-126, miR-451 and miR-494-3P (in Nasal natural killer cell lymphoma (NNKCL)). Also, viral assessed micro RNAs were miR-BART1-5P (in DLBCL and NNKTCL), miR-BART-5 (in CHL), and EBV-miR-BART20-5P (in NNKCL). In conclusion, it could be suggested that EBV-encoded-microRNAs and EBV-induced cellular-microRNAs can be utilized as helpful factors for different types of lymphoma diagnoses or prognostic factors. Moreover, the mentioned microRNAs can also be promising therapeutic targets and can be used to modulate the oncogenes.

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Acknowledgements

We gratefully acknowledge the Vice-Chancellor for Research and Technology, Hormozgan University of Medical Sciences, Bandar Abbas, and Tehran University of Medical Sciences, Tehran, Iran. Also, we are sincerely thankful to our counsellors in Clinical Research Development Center of Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

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Author notes

  1. Saber Soltani and Armin Zakeri contributed equally to this work.

Authors and Affiliations

  1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Saber Soltani & Milad Zandi

  2. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran

    Saber Soltani & Milad Zandi

  3. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Armin Zakeri & Saba Seifpour

  4. Department of Virology, Iran University of Medical Sciences, Tehran, Iran

    Alireza Tabibzadeh

  5. Pediatric Surgery Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Amir Mohammad Zakeri

  6. Razi Vaccine and Serum Research Institute, Karaj, Iran

    Saba Siavoshi

  7. Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

    Abbas Farahani

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  1. Saber Soltani
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  2. Armin Zakeri
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Contributions

SS and AF designed the study, carried out the search, study selection, data abstraction, analysis and drafted the manuscript. AT, AZ, AMZ and MZ carried out the search, study selection, data abstraction, analysis and drafted the manuscript. AT, SASI, and SASE participated in study selection, checked data abstraction and analysis. All authors reviewed and edited the manuscript and approved the final version of the manuscript.

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Correspondence to Abbas Farahani.

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Soltani, S., Zakeri, A., Tabibzadeh, A. et al. A review on EBV encoded and EBV-induced host microRNAs expression profile in different lymphoma types. Mol Biol Rep 48, 1801–1817 (2021). https://doi.org/10.1007/s11033-021-06152-z

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