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Epidemiological surveillance of chikungunya fever in Mexico since its introduction in 2014–2016 and identification of circulating genotypes

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Abstract

In 2014, the chikungunya virus (CHIKV) was detected for the first time in Mexico, the identified strain was the one corresponding to the Asian genotype which was phylogenetically grouped with the strains that circulated in the British Virgin Islands outbreak and was later classified with lineages of Caribbean strains. In three years, 13,569 cases of chikungunya were registered in Mexico. Although the transmission and spread of the virus are now considered a moderate risk, the danger that the virus reemerges is not ruled out due to the infestation of Aedes mosquitoes. In this study, we reviewed the chikungunya fever (CHIKF) cases reported between 2014 and 2016 to reanalyze the data. Seventeen cases were selected from different states where the circulation of the virus had been reported. Statistical data were analyzed and a retrospective analysis was carried out. Nucleic acid sequences were determined of these 17 samples. 2015 was the year with the highest number of cases (92.8%) and they were detected in 28 states of the country. There is a predominance of females, and the most affected age group was between 25 and 44 years. In 2016, CHIKV genotypes were not known, in this study the presence of the Asian genotype of Caribbean lineage was confirmed. The presence of the West African and ECSA genotypes was phylogenetically ruled out. The sequences obtained were deposited in GeneBank.

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Source: Unified Epidemiological Surveillance Information System (SUIVE) Mexico

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Acknowledgements

We acknowledge to the personnel of the Departments of Virology and Molecular Biology of the InDRE, Ministry of Health of México, likewise the Department of Immunology and Biochemistry of the ENCB, IPN for their support throughout this study. We are grateful to the anonymous reviewers to improve the readability of the manuscript.

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Authors and Affiliations

  1. Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico

    Belem Torres-Longoria & María M. B. Moreno-Altamirano

  2. Laboratorio de Inmunología Celular e Inmunopatogénesis, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico

    María Eugenia Castro-Mussot

  3. Laboratorio Biotecnología y Bioinformática Genómica, Departamento de Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Universidad Nacional Autónoma de México, Mexico City, Mexico

    Alfonso Méndez-Tenorio

  4. Departamento de Virología, Instituto de Diagnóstico y Referencia Epidemiológicos “Dr. Manuel Martínez Báez” (InDRE), Secretaria de Salud, Mexico City, Mexico

    Belem Torres-Longoria, Alma Núñez-León, María de la Luz Torres & Mauricio Vázquez-Pichardo

  5. Unidad de Desarrollo Tecnológico e Investigación Molecular, Instituto de Diagnóstico y Referencia Epidemiológicos “Dr, Manuel Martínez Báez” (InDRE), Secretaria de Salud, Mexico City, Mexico

    David Esaú Fragoso-Fonseca, Noé Escobar-Escamilla, Claudia Wong-Arámbula, José Ernesto Ramírez-González & Irma López-Martínez

  6. Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Mexico City, Mexico

    Jorge Membrillo-Hernández

  7. División de Estudios de Posgrado, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico

    José Alberto Díaz-Quiñónez

Authors
  1. Belem Torres-Longoria
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  2. David Esaú Fragoso-Fonseca
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  3. Alma Núñez-León
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  4. María de la Luz Torres
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  5. Mauricio Vázquez-Pichardo
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  6. Noé Escobar-Escamilla
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  7. Claudia Wong-Arámbula
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  8. José Ernesto Ramírez-González
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  9. Alfonso Méndez-Tenorio
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  10. María Eugenia Castro-Mussot
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  11. María M. B. Moreno-Altamirano
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  12. Jorge Membrillo-Hernández
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  13. Irma López-Martínez
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  14. José Alberto Díaz-Quiñónez
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Contributions

BTL, DEFF, ANL, MLTR, CWA, collected data, developed the experiments. MVP, NEE, JERG, AMT, analyzed the data and planned experiments. MECM and MMBMA reviewed the tables, figures and graphics design JMH, ILM and JADQ provide materials, analyzed results and wrote the manuscript.

Corresponding author

Correspondence to José Alberto Díaz-Quiñónez.

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Conflict of interest

All authors of this manuscript declare no conflict of interest.

Ethical approval

Residual samples were recovered from routine CHIKV screening as part of the national chikungunya program, so neither Institutional Review Board (IRB) approval nor informed consent from patients was required.

Research involving human and/or animal participants

This article does not contain any studies with human participants or animals performed by any of the authors.

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Torres-Longoria, B., Fragoso-Fonseca, D.E., Núñez-León, A. et al. Epidemiological surveillance of chikungunya fever in Mexico since its introduction in 2014–2016 and identification of circulating genotypes. Mol Biol Rep 48, 1967–1975 (2021). https://doi.org/10.1007/s11033-021-06151-0

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  • DOI: https://doi.org/10.1007/s11033-021-06151-0

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