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Evaluation of the clinical significance of RNase III enzyme DROSHA in pediatrics acute lymphocytic leukemia

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Abstract

Acute lymphocytic leukemia (ALL) is one of the subtypes of leukemia; it is one of the leading causes of malignancy and morbidity and childhood mortality. This study examined the dysregulation of DROSHA and its clinical implications in ALL. In the case-control investigation, we have included 140 samples, consisting of 70 peripheral whole blood samples diagnosed with ALL and 70 age and sex-matched healthy children, to assess the level of expression of DROSHA mRNA between two groups. Quantitative Real-Time PCR was used to establish the level of DROSHA gene expression in the patients and controls. The results revealed that DROSHA was overexpressed in patients compared with controls (p < 0.001). There were no major differences between DROSHA expression and demographic factors and clinicopathological parameters (p > 0.001). The finding of the study revealed that DROSHA expression in ALL patients is significantly up-regulated; which is suggesting that may be served as a critical role in the pathogenesis of ALL. Also, DROSHA will possibly be utilized as a novel therapeutic target for ALL patients within the future.

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Acknowledgements

This research was taken from Ahar Branch, Islamic Azad University, Ph.D. thesis. We wish all the participants to be respected.

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The present survey has no funds.

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Authors and Affiliations

  1. Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran

    Mahbobeh Hajirostamlou & Saeid Ghorbian

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  1. Mahbobeh Hajirostamlou
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  2. Saeid Ghorbian
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Correspondence to Saeid Ghorbian.

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Study design was approved by the local ethics committee of Tabriz University of Medical Sciences.

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Hajirostamlou, M., Ghorbian, S. Evaluation of the clinical significance of RNase III enzyme DROSHA in pediatrics acute lymphocytic leukemia. Mol Biol Rep 48, 451–456 (2021). https://doi.org/10.1007/s11033-020-06072-4

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  • DOI: https://doi.org/10.1007/s11033-020-06072-4

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