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Evaluation of the clinical significance of RNase III enzyme DROSHA in pediatrics acute lymphocytic leukemia

Molecular Biology Reports volume 48, pages 451–456 (2021)Cite this article

Abstract

Acute lymphocytic leukemia (ALL) is one of the subtypes of leukemia; it is one of the leading causes of malignancy and morbidity and childhood mortality. This study examined the dysregulation of DROSHA and its clinical implications in ALL. In the case-control investigation, we have included 140 samples, consisting of 70 peripheral whole blood samples diagnosed with ALL and 70 age and sex-matched healthy children, to assess the level of expression of DROSHA mRNA between two groups. Quantitative Real-Time PCR was used to establish the level of DROSHA gene expression in the patients and controls. The results revealed that DROSHA was overexpressed in patients compared with controls (p < 0.001). There were no major differences between DROSHA expression and demographic factors and clinicopathological parameters (p > 0.001). The finding of the study revealed that DROSHA expression in ALL patients is significantly up-regulated; which is suggesting that may be served as a critical role in the pathogenesis of ALL. Also, DROSHA will possibly be utilized as a novel therapeutic target for ALL patients within the future.

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Acknowledgements

This research was taken from Ahar Branch, Islamic Azad University, Ph.D. thesis. We wish all the participants to be respected.

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The present survey has no funds.

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  1. Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran

    Mahbobeh Hajirostamlou & Saeid Ghorbian

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  1. Mahbobeh Hajirostamlou
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  2. Saeid Ghorbian
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Correspondence to Saeid Ghorbian.

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Study design was approved by the local ethics committee of Tabriz University of Medical Sciences.

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Hajirostamlou, M., Ghorbian, S. Evaluation of the clinical significance of RNase III enzyme DROSHA in pediatrics acute lymphocytic leukemia. Mol Biol Rep 48, 451–456 (2021). https://doi.org/10.1007/s11033-020-06072-4

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  • DOI: https://doi.org/10.1007/s11033-020-06072-4

Keywords

  • DROSHA
  • Acute lymphocytic leukemia
  • RNase III enzyme
  • ALL