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The role of exosomes in stroke

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Abstract

Stroke is induced by a partial disruption of cerebral blood flow to the brain and is related to high morbidity and mortality. In the central nervous system, exosomes have been proven to exert neuroprotective effects, reducing brain damage following a stroke. This review was performed by searching the relevant articles in the SCIENCEDIRECT, PUBMED, and Web of Science databases from respective inception to November 2018. We review the relationship between exosomes and angiogenesis, neurogenesis, antiapoptosis, autophagy, and the blood–brain barrier in stroke. Moreover, exosomes are found to be a promising tool for the diagnosis and treatment of stroke. In summary, exosomes provide a novel way to alleviate brain damage following a stroke.

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  1. Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, 050051, Hebei, People’s Republic of China

    Man-Man Wang, Ya-Shuo Feng, Zi-Xuan Tan, Ying Xing & Feng Zhang

  2. Department of Clinical Laboratory Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, People’s Republic of China

    Fang Dong

  3. Hebei Provincial Orthopedic Biomechanics Key Laboratory, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, People’s Republic of China

    Feng Zhang

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Wang, MM., Feng, YS., Tan, ZX. et al. The role of exosomes in stroke. Mol Biol Rep 47, 6217–6228 (2020). https://doi.org/10.1007/s11033-020-05569-2

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