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Insight into the expression of toll-like receptors 2 and 4 in patients with abdominal aortic aneurysm

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Abstract

An abdominal aortic aneurysm (AAA) is a relatively common, life-threatening disease prevalent in persons over the age of 65. In recent years, an increasing number of studies have suggested that pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), may serve as important regulators in the development of AAAs. In this study, we evaluated the TLR2 and TLR4 expression in the aortic wall and blood of patients with AAA. The TLR2 and TLR4 mRNA expression were significantly higher in the blood of patients with AAA than in the blood of healthy volunteers (p = 0.009 and p = 0.010, respectively). The expression of TLR2 and TLR4 transcripts was also higher in the blood compared with the aortic wall tissue of AAA patients (p = 0.001 for both). Higher TLR2 protein expression was observed in the aortic wall of AAA patients compared with the blood (p = 0.026). A significantly higher concentration of TNF-α and IL-4 in patients with AAA than in healthy volunteers (p < 0.001 for both) was noticed. This study suggests that TLR2 may play a role in the inflammatory response in the aorta, both locally and systemically, in patients with AAA.

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Acknowledgements

This work was supported by the Medical University of Vienna, Grant No. UE73101019. The authors would like to thank all volunteers for their valuable contribution to the study.

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Authors and Affiliations

  1. Laboratory of Virology, Institute of Medical Biology, Polish Academy of Sciences, 106 St., 93–232, Lodz, Poland

    Agnieszka Jabłońska

  2. Division of Vascular Surgery, Department of Surgery, Medical University of Vienna, Vienna General Hospital, Vienna, Austria

    Agnieszka Jabłońska, Christoph Neumayer, Michael Bolliger, Christopher Burghuber, Markus Klinger, Josif Nanobachvili & Ihor Huk

  3. Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

    Svitlana Demyanets

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Jabłońska, A., Neumayer, C., Bolliger, M. et al. Insight into the expression of toll-like receptors 2 and 4 in patients with abdominal aortic aneurysm. Mol Biol Rep 47, 2685–2692 (2020). https://doi.org/10.1007/s11033-020-05366-x

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