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Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells

Molecular Biology Reports volume 47, pages 3065–3076 (2020)Cite this article

Abstract

The cell cycle is a complex and strictly controlled process, consisting of different phases. Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The alterations of cell cycle genes can predispose normal cells to have a cancerous phenotype. Indeed, several mechanisms underlying the deregulation of the cell cycle have been identified in different types of cancer. Cancer stem cells (CSCs), a fraction of tumor cells, are selectively capable of initiating tumor development. However, the deregulation of the cell cycle progression in CSCs still remains incompletely understood. This review describes epigenetic alterations and aberrant transcriptional regulation of cell cycle genes in CSCs as well as cell cycle patterns of CSCs.

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  1. Department of Stem Cell, Health Science Institute, Ege University, Bornova, 35100, Izmir, Turkey

    Hasan Onur Caglar

  2. Department of Medical Biology, Medical Faculty, Ege University, Bornova, 35100, Izmir, Turkey

    Cigir Biray Avci

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Caglar, H.O., Biray Avci, C. Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells. Mol Biol Rep 47, 3065–3076 (2020). https://doi.org/10.1007/s11033-020-05341-6

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Keywords

  • Cell cycle
  • Cyclins
  • Cyclin-dependent kinases
  • Cyclin-dependent kinase inhibitors
  • Cancer
  • Bmi-1
  • Cancer stem cells