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Controlling pathogenesis in Candida albicans by targeting Efg1 and Glyoxylate pathway through naturally occurring polyphenols

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Abstract

Candida albicans has frequently shown resistance to azoles, the commonly used antifungal drugs. Efg1 has dual role under normoxia and hypoxia supporting infection. It is the major regulator of morphogenesis in C. albicans requisite for its pathogenesis. Targeting this protein is expected to render Candida ineffective to undergo filamentation causing virulence. Further the glyoxylate pathway supports the stress resistance and pathogenesis. In the present study an in silico approach and in vitro validation has been performed to find the potential role of polyphenols in controlling hyphal growth in C. albicans. The aspect of changes biome which may provide required niche to the pathogen has been checked which certainly opens the doors towards safe natural polyphenol-based drugs as potent antifungals.

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Authors and Affiliations

  1. Department of Applied Science and Bioinformatics, Indian Institute of Information Technology, Allahabad, 211012, India

    Sonali Mishra, Sangeeta Singh & Krishna Misra

  2. Yeast Molecular Genetics Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India

    Sumit Kumar Rastogi & Sneh Lata Panwar

  3. Medical Mycology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India

    Sumit Kumar Rastogi

  4. Center of Biomedical Research, Lucknow, India

    Manoj Kumar Shrivash & Krishna Misra

  5. Babasaheb Bhimrao Ambedkar University, Lucknow, India

    Manoj Kumar Shrivash

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  1. Sonali Mishra
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  2. Sumit Kumar Rastogi
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  3. Sangeeta Singh
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  4. Sneh Lata Panwar
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  5. Manoj Kumar Shrivash
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  6. Krishna Misra
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Correspondence to Krishna Misra.

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Mishra, S., Rastogi, S.K., Singh, S. et al. Controlling pathogenesis in Candida albicans by targeting Efg1 and Glyoxylate pathway through naturally occurring polyphenols. Mol Biol Rep 46, 5805–5820 (2019). https://doi.org/10.1007/s11033-019-05014-z

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  • DOI: https://doi.org/10.1007/s11033-019-05014-z

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