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Post-exposure distribution of selenium and aluminum ions and their effects on superoxide dismutase activity in mouse brain

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Abstract

The study was conducted to determine how aluminum (Al) and selenium (Se) ions alone and in combination affect superoxide dismutase (SOD) activity and to evaluate the distribution of these elements in the blood and the brain of laboratory mice. SOD activity in mouse brain was evaluated after single-time (within 24 h) and repeated (over 14 days) intraperitoneal (IP) injections of SeO32−, Al3+, and (SeO32−+Al3+) solutions. The control mice received IP injections of the same volume of saline. Aluminum concentration in mouse blood increased both after single-time and repeated injections of AlCl3 and the combined (AlCl3 + Na2SeO3) solutions. The concentration of Se increased in blood after single-time and repeated injections of Na2SeO3 and the combined (AlCl3 + Na2SeO3) solutions. After the single-time injection of the experimental solutions, the concentrations of both Al and Se in mouse brain remained at baseline, but after repeated injections of (AlCl3 + Na2SeO3) solutions increased aluminum concentration. A single IP injection of Al did not change SOD activity in mouse brain, while a single injection of Se or the Se + Al mixture decreased it. After 14 days, IP injections of Al or Se alone did not affect SOD activity, while their combination decreased it. Our results showed that Se ions decreased SOD activity in mouse brain after both single-time and repeated IP injections of selenium-containing solutions. The study failed to show a direct or linear effect of increased Al or Se concentrations on SOD activity in mouse brain.

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Authors and Affiliations

  1. Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania

    Ilona Sadauskiene, Arunas Liekis, Vaida Simakauskiene, Dale Baranauskiene & Rima Naginiene

  2. Department of Biochemistry, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

    Ilona Sadauskiene, Inga Staneviciene, Dale Viezeliene & Dale Baranauskiene

  3. Department of Prosthodontics, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

    Gediminas Zekonis

  4. Laboratory of Molecular Neurobiology of the Neuroscience Institute, Lithuanian University of Health Sciences, Eiveniu St. 4-213, 50161, Kaunas, Lithuania

    Ilona Sadauskiene

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  1. Ilona Sadauskiene
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  2. Arunas Liekis
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  6. Vaida Simakauskiene
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Correspondence to Ilona Sadauskiene.

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Sadauskiene, I., Liekis, A., Staneviciene, I. et al. Post-exposure distribution of selenium and aluminum ions and their effects on superoxide dismutase activity in mouse brain. Mol Biol Rep 45, 2421–2427 (2018). https://doi.org/10.1007/s11033-018-4408-0

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  • DOI: https://doi.org/10.1007/s11033-018-4408-0

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