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Predicting membrane proteins and their types by extracting various sequence features into Chou’s general PseAAC

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Abstract

For many biological functions membrane proteins (MPs) are considered crucial. Due to this nature of MPs, many pharmaceutical agents have reflected them as attractive targets. It bears indispensable importance that MPs are predicted with accurate measures using effective and efficient computational models (CMs). Annotation of MPs using in vitro analytical techniques is time-consuming and expensive; and in some cases, it can prove to be intractable. Due to this scenario, automated prediction and annotation of MPs through CM based techniques have appeared to be useful. Based on the use of computational intelligence and statistical moments based feature set, an MP prediction framework is proposed. Furthermore, the previously used dataset has been enhanced by incorporating new MPs from the latest release of UniProtKB. Rigorous experimentation proves that the use of statistical moments with a multilayer neural network, trained using back-propagation based prediction techniques allows more thorough results.

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Authors and Affiliations

  1. Department of Computer Science, School of Systems and Technology, University of Management and Technology, C-II, Johar Town, P.O. Box 10033, Lahore, 54770, Pakistan

    Ahmad Hassan Butt & Yaser Daanial Khan

  2. Department of Life Sciences, School of Science, University of Management and Technology, C-II, Johar Town, P.O. Box 10033, Lahore, 54770, Pakistan

    Nouman Rasool

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  1. Ahmad Hassan Butt
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Correspondence to Ahmad Hassan Butt.

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Butt, A.H., Rasool, N. & Khan, Y.D. Predicting membrane proteins and their types by extracting various sequence features into Chou’s general PseAAC. Mol Biol Rep 45, 2295–2306 (2018). https://doi.org/10.1007/s11033-018-4391-5

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