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Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle

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Abstract

The availability of dense genomic information has increased genome-wide association studies for the bovine species; however research to assess the effect of single genes on production traits is still important to elucidate the genes functions. On this study the association of IGF1, GH, and PIT1 markers with growth and reproductive traits (birth weight, weaning weight, weight at 12 and 18 months of age, preweaning average daily weight gain, age and weight at first calving, and scrotal circumference at 12 and 18 months of age) were assessed by means of the variance component approach. The phenotypes were adjusted and then analyzed under two animal models, one which considered the polygenic and genotype (IGF1, GH or PIT1 markers) effects (Model 1), and the other which considers only the polygenic effect (Model 2). When the likelihood ratio test and the Bonferroni correction was applied at 5 % significance level, the genetic markers for the IGF1, GH, and PIT1 genes did not influence significantly the traits (p > 0.002). However, evidence of association of IGF1 with birth weight (p = 0.06) and GH with weight at first calving (p = 0.03) and with weight at 12 months of age (p = 0.08) was observed. In conclusion we could not confirm the associations between IGF1, GH, and PIT1 and growth traits that were previously reported in Canchim cattle, and no association was observed between these genes and reproductive traits. Future studies involving functional markers of IGF1, GH and PIT1 genes may help to clarify the role of these genes in growth and reproductive processes.

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Acknowledgments

We would like to thank FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo) for the fellowship received by Grossi DA (06/60043-1) and Grupioni NV (08/09393-7). Buzanskas ME, Regitano LCA, Alencar MM, Munari DP, and Paz CCP were recipients of a CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) fellowship. We also thank the Centre for Genetic Improvement of Livestock for scientific support, especially Dr. Mehdi Sargolzaei for assistance with the statistical analyses, and Embrapa Pecuária Sudeste (Empresa Brasileira de Pesquisa Agropecuária) for providing data.

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Authors and Affiliations

  1. Centre for Genetic Improvement of Livestock, Department of Animal and Poultry Science, University of Guelph, 50 Stone Road East, Guelph, ON, N1G2W1, Canada

    Daniela do Amaral Grossi & Flávio Schramm Schenkel

  2. Departamento de Ciências Exatas, UNESP - Univ Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Via de Acesso Prof. Paulo Donato Castellane, Jaboticabal, SP, 14884-900, Brazil

    Marcos Eli Buzanskas, Natalia Vinhal Grupioni & Danísio Prado Munari

  3. Instituto de Zootecnia, Centro APTA de Bovinos de Corte, Rodovia Carlos Tonanni, km 94, Sertãozinho, SP, 14174000, Brazil

    Claudia Cristina Paro de Paz

  4. Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14049-900, Brazil

    Claudia Cristina Paro de Paz

  5. Empresa Brasileira de Pesquisa Agropecuária, EMBRAPA Pecuária Sudeste, Rodovia Washington Luiz, km 234, São Carlos, SP, 13560-970, Brazil

    Luciana Correia de Almeida Regitano & Maurício Mello de Alencar

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  1. Daniela do Amaral Grossi
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  2. Marcos Eli Buzanskas
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Correspondence to Danísio Prado Munari.

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Grossi, D.d., Buzanskas, M.E., Grupioni, N.V. et al. Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle. Mol Biol Rep 42, 245–251 (2015). https://doi.org/10.1007/s11033-014-3767-4

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  • DOI: https://doi.org/10.1007/s11033-014-3767-4

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