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Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris

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Abstract

Smoking, alcohol consumption and higher body mass index (BMI) are well established risk factors for psoriasis and also associated with the clinical traits of the disease. And the genetic influences on these three risk factors indeed exist. Previously studies have demonstrated these risk factors related genetic variants may also play a role in the development of risk factors-related diseases. Then we performed a hospital-based study in order to evaluate the combined effect of the risk factors and their related polymorphism rs6265 in brain-derived neurotrophic factor (BDNF) gene on psoriasis vulgaris (PV) risk and clinic traits. The case–control study involved 660 subjects including 345 cases and 315 controls in Chinese Han population. The variant of rs6265 was typed by SNaPshot Multiplex Kit (Applied Biosystems Co., USA). We confirmed that higher BMI (≥25), smoking and alcohol consumption were risk factors for PV, and the estimated ORs were 1.63(95 % confidence interval (CI); 1.12–2.37), 2.09(95 % CI; 1.44–3.03) and 1.65(95 % CI; 1.15–2.37) respectively. Genotype and allele distributions did not differ significantly between case and control. However, we found combined effect of rs6265 genotype (GG) and higher BMI (≥25) increased risk of PV (OR = 2.09; 95 % CI, 1.02–4.28; P < 0.05; adjusted OR = 3.19; 95 % CI, 1.37–7.45; P < 0.05) and clinically severity of PV (OR = 2.71; 95 % CI, 1.09–6.72; P < 0.05; adjusted OR = 1.25; 95 % CI, 1.10–1.40; P < 0.05). But none such significant combined effect was observed between others genotype (AA and AG) and other risk factors. In conclusions, the combined effect of BDNF rs6265 genotype (GG) and higher BMI may increases the risk and clinical severity of PV in Chinese Han population.

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Acknowledgments

We are most grateful to the members of all the families who have so willingly participated in this study. This work was supported by grants from Postdoctoral Science Foundation of China (2012M521580); Foundation for Distinguished Young Talents in Higher Education of Guangdong Province (2012LYM_0070); Guangdong Provincial Medical Research Fund (B2012282);The China Natural Science Foundation (81301351, 81101186); The Natural Science Foundation of Guangdong Province (S2013040012415).

Funding

This work was supported by grants from Postdoctoral Science Foundation of China (2012M521580); Foundation for Distinguished Young Talents in Higher Education of Guangdong Province (2012LYM_0070); Guangdong Provincial Medical Research Fund (B2012282);The China Natural Science Foundation (81301351, 81101186); The Natural Science Foundation of Guangdong Province (S2013040012415).

Conflict of interest

The data is an original data, has not been published before and is not being considered for publication elsewhere. The authors state no conflict of interest.

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Authors and Affiliations

  1. Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Cheng Quan & Jie Zheng

  2. Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China

    Kun-Ju Zhu, Zhong Liu, Huan Liu, Cheng-Yao Zhu & Yi-Ming Fan

  3. Department of Dermatology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China

    Chi Zhang

  4. Key laboratory of aging-related Cardio-cerebral diseases of Guangdong Province, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China

    Ke-Shen Li

  5. Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China

    Cheng Quan

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  1. Cheng Quan
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  2. Kun-Ju Zhu
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  3. Chi Zhang
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Correspondence to Kun-Ju Zhu.

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Cheng Quan and Kun-Ju Zhu contributed equally to this work.

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Quan, C., Zhu, KJ., Zhang, C. et al. Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris. Mol Biol Rep 41, 7015–7022 (2014). https://doi.org/10.1007/s11033-014-3589-4

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