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RETRACTED ARTICLE: Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease

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This article was retracted on 18 August 2015

Abstract

Kawasaki disease is a pediatric systemic vasculitis of unknown etiology, for which a genetic influence is suspected. But whether single nucleotide polymorphism (SNP) of caspase-3 rs72689236 is associated with Kawasaki disease is controversial. The aim of our study is to assess the association between the SNP of caspase-3 and risk for Kawasaki disease. We searched PubMed, MEDLINE, EMBASE, Springer, Elsevier Science Direct, Cochrane Library Google scholar, CNKI (China National Knowledge Infrastructure, in Chinese) and Wanfang database (in Chinese) to identify studies investigating the association between rs72689236 polymorphism and Kawasaki disease occurrence. There were five eligible studies, which included 4,241 (case group 1,560; control group 2,681) participants in this meta-analysis. Pooled odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were calculated in a fixed-effects model (the Mantel–Haenszel method) or a random-effects model (the DerSimonian and Laird method) when appropriate. Significant associations were found under the overall ORs for A-allele comparison (A vs. G, pooled OR 1.33, 95 % CI 1.21–1.46), AA versus GG comparison (pooled OR 1.64, 95 % CI 1.35–2.00), GA versus GG comparison (pooled OR 1.42, 95 % CI 1.24–1.63), recessive model (AA vs. GG + GA, pooled OR 1.37, 95 % CI 1.15–1.64) and dominant model (AA + GA vs. GG, pooled OR 1.47, 95 % CI 1.29–1.67). This meta-analysis suggested that SNP rs72689236 of caspase-3 might be associated with susceptibility of Kawasaki disease and the allele A might increase the risk of Kawasaki disease in Asian samples such as Japanese and Chinese. In addition, individual studies with large sample size are needed to further evaluate the associations in various ethnic populations.

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Acknowledgment

This work was funded by Liaoning Province Science and Technology Department, China (No. 2013225089).

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Authors and Affiliations

  1. Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning, China

    Yanlin Xing, Hong Wang, Xianyi Yu, Rui Chen, Ce Wang, Xuexin Yu & Le Sun

  2. Experimental research center, Shengjing Hospital of China Medical University, Shenyang, 110004, China

    Xiaomei Liu

Authors
  1. Yanlin Xing
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  2. Hong Wang
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  3. Xiaomei Liu
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  4. Xianyi Yu
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  5. Rui Chen
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  6. Ce Wang
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  7. Xuexin Yu
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  8. Le Sun
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Corresponding author

Correspondence to Xianyi Yu.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Xing, Y., Wang, H., Liu, X. et al. RETRACTED ARTICLE: Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease. Mol Biol Rep 41, 6377–6381 (2014). https://doi.org/10.1007/s11033-014-3517-7

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  • DOI: https://doi.org/10.1007/s11033-014-3517-7

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