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RETRACTED ARTICLE: Identification of featured biomarkers in different types of lung cancer with DNA microarray

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This article was retracted on 18 August 2015

Abstract

Lung cancer is a worldwide leading cause of cancer-related death. The aim of this study was to identify target genes and specific biomarkers for identification and treatment of different types of lung cancer with DNA microarray. Gene expression profile GSE6044 and miRNA microarray profile GSE17681 were downloaded from Gene Expression Omnibus database. The differentially expressed genes (DEGs) and miRNAs were screened with multtest package in R language. Then, functional enrichment analysis of identified DEGs was performed. Furthermore, the verified target genes based on screened miRNAs were selected from miRTarBase and miRecords databases. Then miRNA-target gene regulation network was constructed. APOE, CDC6 and ATP2B1were involved in most of the functions obtained for adenocarcinomas, small cell lung cancer and squamous cell carcinomas, respectively. The target DEGs of differentially expressed hsa-miR-29a included FGG in adenocarcinoma, RAN and COL4A1 in small cell lung cancer, GLUL in squamous cell carcinoma. The target DEGs of has-miR-7 were SNCA and SLC7A5 in adenocarcinoma and small cell lung cancer, respectively. ICAM1 and KIT were the target DEGs of hsa-miR-222 in adenocarcinoma and squamous cell carcinoma. The miRNAs and their differentially expressed target genes have the potential to be used in clinic for diagnosis and treatment of different kinds of lung cancer in the future.

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Acknowledgments

We wish to express our warm thanks to all the authors who contributed a lot to the research.

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Authors and Affiliations

  1. Department of Respiratory Medicine, Zhou Pu Hospital, 1500 Zhouyuan Road, Pudong new District, Shanghai, 201318, China

    Chao Zhou, Hao Chen, Li Han & An Wang

  2. Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing, 100853, China

    Liang-an Chen

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  1. Chao Zhou
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  2. Hao Chen
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  3. Li Han
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  4. An Wang
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  5. Liang-an Chen
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Correspondence to Chao Zhou or Liang-an Chen.

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The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Zhou, C., Chen, H., Han, L. et al. RETRACTED ARTICLE: Identification of featured biomarkers in different types of lung cancer with DNA microarray. Mol Biol Rep 41, 6357–6363 (2014). https://doi.org/10.1007/s11033-014-3515-9

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  • DOI: https://doi.org/10.1007/s11033-014-3515-9

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