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RETRACTED ARTICLE: Key genes associated with osteoporosis revealed by genome wide gene expression analysis

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This article was retracted on 18 August 2015

Abstract

Gene expression profiles of circulating monocytes were analyzed to identify key genes associated with osteoporosis. Raw microarray data were downloaded from gene expression omnibus under accession number GSE7158, including 8 microarray dataset for patients with high peak bone mass (PBM) and 8 for low PBM. Package linear models for microarray data of R was adopted to screen out differentially expressed genes (DEGs). Gene ontology enrichment analysis and Kyoto encyclopedia of genes and genomes pathway analysis were performed with plug-ins of cytoscape. Protein–protein interaction network was constructed using FunCoup. A total of 283 DEGs were identified in low-PBM group, including 135 up- and 148 down-regulated genes. A considerable part of DEGs were localized in plasma membrane. Several ion transport-related pathways were revealed, such as mineral absorption and carbohydrate digestion and absorption. A range of DEGs were identified and some of them were related to calcium transport as well as osteoporosis. These findings are helpful in disclosing the pathogenetic mechanisms of osteoporosis.

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Acknowledgments

This study was supported by Shanghai Municipal Education Commission (Grant no. 12YZ039) and Shanghai Municipal Commission of Health and Family Planning (20134224).

Conflict of interest

All authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Orthopedics, Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, People’s Republic of China

    Jie Chen, Lei Wang, Yuhui Shen, Jian Yu, Tingjun Ye, Chengyu Zhuang & Weibin Zhang

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  1. Jie Chen
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  2. Lei Wang
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  3. Yuhui Shen
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  4. Jian Yu
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  6. Chengyu Zhuang
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  7. Weibin Zhang
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Correspondence to Yuhui Shen or Weibin Zhang.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Chen, J., Wang, L., Shen, Y. et al. RETRACTED ARTICLE: Key genes associated with osteoporosis revealed by genome wide gene expression analysis. Mol Biol Rep 41, 5971–5977 (2014). https://doi.org/10.1007/s11033-014-3474-1

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  • DOI: https://doi.org/10.1007/s11033-014-3474-1

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