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RETRACTED ARTICLE: Genetic variations in the KIR gene family may contribute to susceptibility to ankylosing spondylitis: a meta-analysis

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This article was retracted on 18 August 2015

Abstract

The present meta-analysis of relevant case–control studies was conducted to investigate the possible relationships between genetic variations in the killer cell immunoglobulin-like receptor (KIR) gene clusters of the human KIR gene family and susceptibility to ankylosing spondylitis (AS). The following electronic databases were searched for relevant articles without language restrictions: the Web of Science, the Cochrane Library Database, PubMed, EMBASE, CINAHL, the Chinese Biomedical Database (CBM) and Chinese National Knowledge Infrastructure (CNKI) databases, covering all papers published until 2013. STATA statistical software was adopted in this meta-analysis as well. We also calculated the crude odds ratios (OR) and its 95 % confidence intervals (95 % CI). Seven case–control studies with 1,004 patients diagnosed with AS and 2,138 healthy cases were implicated in our meta-analysis, and 15 genes in the KIR gene family were also evaluated. The results of our meta-analysis show statistical significance between the genetic variations in the KIR2DL1, KIR2DS4, KIR2DS5 and KIR3DS1 genes and an increased susceptibility to AS (KIR2DL1: OR 7.82, 95 % CI 3.87–15.81, P< 0.001; KIR2DS4: OR 1.91, 95 % CI 1.16–3.13, P = 0.010; KIR2DS5: OR1.51, 95 % CI 1.14–2.01, P = 0.004; KIR3DS1: OR 1.58, 95 % CI 1.34–1.86, P< 0.001; respectively). However, we failed to found positive correlations between other genes and susceptibility to AS (all P >0.05). The current meta-analysis provides reliable evidence that genetic variations in the KIR gene family may contribute to susceptibility to AS, especially for the KIR2DL1, KIR2DS4, KIR2DS5 and KIR3DS1 genes.

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References

  1. Tam LS, Gu J, Yu D (2010) Pathogenesis of ankylosing spondylitis. Nat Rev Rheumatol 6:399–405. doi:10.1038/nrrheum.2010.79

    Article  PubMed  Google Scholar 

  2. Chung SD, Chen YK, Liu SP, Lin HC (2013) Association between ed in ankylosing spondylitis: a population-based study. Int J Impot Res 25:229–233. doi:10.1038/ijir.2013.14

    Article  PubMed  Google Scholar 

  3. Dean LE, Jones GT, Macdonald AG, Downham C, Sturrock RD, Macfarlane GJ (2013) Global prevalence of ankylosing spondylitis. Rheumatology (Oxford). doi:10.1093/rheumatology/ket387

    Google Scholar 

  4. Braun J, Sieper J (2007) Ankylosing spondylitis. Lancet 369:1379–1390. doi:10.1016/S0140-6736(07)60635-7

    Article  PubMed  Google Scholar 

  5. Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, Oppermann U, Dilthey A et al (2011) Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet 43:761–767. doi:10.1038/ng.873

  6. Diaz-Pena R, Blanco-Gelaz MA, Suarez-Alvarez B, Martinez-Borra J, Lopez-Vazquez A, Alonso-Arias R, Bruges-Armas J, Vidal-Castineira JR et al (2008) Activating KIR genes are associated with ankylosing spondylitis in Asian populations. Hum Immunol 69:437–442. doi:10.1016/j.humimm.2008.04.012

    Article  CAS  PubMed  Google Scholar 

  7. Tajik N, Shahsavar F, Poormoghim H, Radjabzadeh MF, Mousavi T, Jalali A (2011) KIR3DL1+HLA-B BW4ILE80 and KIR2DS1+HLA-C2 combinations are both associated with ankylosing spondylitis in the Iranian population. Int J Immunogenet 38:403–409. doi:10.1111/j.1744-313X.2011.01024.x

    Article  CAS  PubMed  Google Scholar 

  8. Sivori S, Falco M, Moretta L, Moretta A (2010) Extending killer Ig-like receptor function: from HLA class I recognition to sensors of microbial products. Trends Immunol 31:289–294. doi:10.1016/j.it.2010.05.007

    Article  CAS  PubMed  Google Scholar 

  9. Dupont B, Selvakumar A, Steffens U (1997) The killer cell inhibitory receptor genomic region on human chromosome 19q13.4. Tissue Antigens 49:557–563. http://www.ncbi.nlm.nih.gov/pubmed/9234476

  10. McCappin J, Harvey D, Wordsworth BP, Middleton D (2010) No association of KIR3DL1 or KIR3DS1 or their alleles with ankylosing spondylitis. Tissue Antigens 75:68–73. doi:10.1111/j.1399-0039.2009.01392.x

    Article  CAS  PubMed  Google Scholar 

  11. Campbell KS, Purdy AK (2011) Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations. Immunology 132:315–325. doi:10.1111/j.1365-2567.2010.03398.x

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Mousavi T, Poormoghim H, Moradi M, Tajik N, Shahsavar F, Asadifar B (2010) Inhibitory killer cell immunoglobulin-like receptor KIR3DL1 in combination with HLA-B Bw4iso protect against ankylosing spondylitis. Iran J Immunol 7:88–95

  13. Jiao YL, Zhang BC, You L, Li JF, Zhang J, Ma CY, Cui B, Wang LC et al (2010) Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis. J Clin Immunol 30:840–844. doi:10.1007/s10875-010-9444-z

    Article  CAS  PubMed  Google Scholar 

  14. Yan H, Wang W, Hu ZD (2012) Association between the subtypes of HLA-B*27 and the polymorphisms of KIR gene. Shanxi Med J 41:281–284

    Google Scholar 

  15. Stang A (2010) Critical evaluation of the Newcastle–Ottawa Scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25:603–605. doi:10.1007/s10654-010-9491-z

    Article  PubMed  Google Scholar 

  16. Zintzaras E, Ioannidis JP (2005) Hegesma: genome search meta-analysis and heterogeneity testing. Bioinformatics 21:3672–3673. doi:10.1093/bioinformatics/bti536

    Article  CAS  PubMed  Google Scholar 

  17. Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L (2006) Comparison of two methods to detect publication bias in meta-analysis. JAMA 295:676–680. doi:10.1001/jama.295.6.676

    Article  CAS  PubMed  Google Scholar 

  18. Diaz-Pena R, Vidal-Castineira JR, Alonso-Arias R, Suarez-Alvarez B, Vicario JL, Solana R, Collantes E, Lopez-Vazquez A et al (2010) Association of the KIR3DS1*013 and KIR3DL1*004 alleles with susceptibility to ankylosing spondylitis. Arthritis Rheum 62:1000–1006. doi:10.1002/art.27332

    Article  CAS  PubMed  Google Scholar 

  19. Harvey D, Pointon JJ, Sleator C, Meenagh A, Farrar C, Sun JY, Senitzer D, Middleton D et al (2009) Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis. Ann Rheum Dis 68:595–598. doi:10.1136/ard.2008.095927

    Article  CAS  PubMed  Google Scholar 

  20. Nowak I, Majorczyk E, Wisniewski A, Pawlik A, Magott-Procelewska M, Passowicz-Muszynska E, Malejczyk J, Ploski R et al (2010) Does the KIR2DS5 gene protect from some human diseases? PLoS ONE 5:e12381. doi:10.1371/journal.pone.0012381

    Article  PubMed Central  PubMed  Google Scholar 

  21. Zvyagin IV, Mamedov IZ, Britanova OV, Staroverov DB, Nasonov EL, Bochkova AG, Chkalina AV, Kotlobay AA et al (2010) Contribution of functional KIR3DL1 to ankylosing spondylitis. Cell Mol Immunol 7:471–476. doi:10.1038/cmi.2010.42

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Fauriat C, Ivarsson MA, Ljunggren HG, Malmberg KJ, Michaelsson J (2010) Education of human natural killer cells by activating killer cell immunoglobulin-like receptors. Blood 115:1166–1174. doi:10.1182/blood-2009-09-245746

    Article  CAS  PubMed  Google Scholar 

  23. Qin H, Wang Z, Du W, Lee WH, Wu X, Riggs AD, Liu CP (2011) Killer cell ig-like receptor (KIR) 3DL1 down-regulation enhances inhibition of type 1 diabetes by autoantigen-specific regulatory T cells. Proc Natl Acad Sci USA 108:2016–2021. doi:10.1073/pnas.1019082108

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Moon SJ, Oh EJ, Kim Y, Kim KS, Kwok SK, Ju JH, Park KS, Kim HY et al (2013) Diversity of killer cell immunoglobulin-like receptor genes in uveitis associated with autoimmune diseases: ankylosing spondylitis and behcet disease. Ocul Immunol Inflamm 21:135–143. doi:10.3109/09273948.2012.754905

    Article  CAS  PubMed  Google Scholar 

  25. Jiao YL, Ma CY, Wang LC, Cui B, Zhang J, You L, Chen ZJ, Li JF et al (2008) Polymorphisms of KIRS gene and HLA-C alleles in patients with ankylosing spondylitis: Possible association with susceptibility to the disease. J Clin Immunol 28:343–349. doi:10.1007/s10875-008-9183-6

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We would like to acknowledge the reviewers for their helpful comments on this paper.

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. 1st Department of Trauma Surgery, Yantai Hill Hospital of Yantai, Yantai, 264000, People’s Republic of China

    Hai-Ning Zuo

  2. Department of Hand Surgery, Yantai Hill Hospital of Yantai, Yantai, 264000, People’s Republic of China

    Zhi-Long Wang

  3. Department of Orthopedics, The First People’s Hospital of Nantong, Nantong, 226000, People’s Republic of China

    Dao-Ran Cui

  4. 3rd Department of Trauma Surgery, Yantai Hill Hospital of Yantai, Jiefang Road No. 91, Zhifu District, Yantai, 264000, People’s Republic of China

    Da-Jiang Xin

Authors
  1. Hai-Ning Zuo
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  2. Zhi-Long Wang
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  4. Da-Jiang Xin
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Corresponding author

Correspondence to Da-Jiang Xin.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Zuo, HN., Wang, ZL., Cui, DR. et al. RETRACTED ARTICLE: Genetic variations in the KIR gene family may contribute to susceptibility to ankylosing spondylitis: a meta-analysis. Mol Biol Rep 41, 5311–5319 (2014). https://doi.org/10.1007/s11033-014-3402-4

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  • DOI: https://doi.org/10.1007/s11033-014-3402-4

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