Abstract
Among the bacteria groups, most of them are known to be beneficial to human being whereas only a minority is being recognized as harmful. The pathogenicity of bacteria is due, in part, to their rapid adaptation in the presence of selective pressures exerted by the human host. In addition, through their genomes, bacteria are subject to mutations, various rearrangements or horizontal gene transfer among and/or within bacterial species. Bacteria’s essential metabolic functions are generally encoding by the core genes. Apart of the core genes, there are several number of mobile genetic elements (MGE) acquired by horizontal gene transfer that might be beneficial under certain environmental conditions. These MGE namely bacteriophages, transposons, plasmids, and pathogenicity islands represent about 15 % Staphylococcus aureus genomes. The acquisition of most of the MGE is made by horizontal genomic islands (GEI), recognized as discrete DNA segments between closely related strains, transfer. The GEI contributes to the wide spread of microorganisms with an important effect on their genome plasticity and evolution. The GEI are also involve in the antibiotics resistance and virulence genes dissemination. In this review, we summarize the mobile genetic elements of S. aureus.
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References
Lindsay JA, Holden MT (2004) Staphylococcus aureus: superbug, super genome? Trends Microbiol 12(8):378–385. doi:10.1016/j.tim.2004.06.004
Frost LS, Leplae R, Summers AO, Toussaint A (2005) Mobile genetic elements: the agents of open source evolution. Nat Rev Microbiol 3(9):722–732. doi:10.1038/nrmicro1235
Siefert JL (2009) Defining the mobilome. Methods Mol Biol 532:13–27. doi:10.1007/978-1-60327-853-9_2
Hacker J, Kaper JB (2000) Pathogenicity islands and the evolution of microbes. Annu Rev Microbiol 54:641–679. doi:10.1146/annurev.micro.54.1.641
Weigel LM, Clewell DB, Gill SR, Clark NC, McDougal LK, Flannagan SE, Kolonay JF, Shetty J, Killgore GE, Tenover FC (2003) Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus. Science 302(5650):1569–1571. doi:10.1126/science.1090956
Mlynarczyk A, Mlynarczyk G, Jeljaszewicz J (1998) The genome of Staphylococcus aureus: a review. Zentralblatt fur Bakteriologie 287(4):277–314
Sharma VK, Johnston JL, Morton TM, Archer GL (1994) Transcriptional regulation by TrsN of conjugative transfer genes on staphylococcal plasmid pGO1. J Bacteriol 176(12):3445–3454
Goering RV, Teeman BA, Ruff EA (1985) Comparative physical and genetic maps of conjugal plasmids mediating aminoglycoside resistance in Staphylococcus aureus in the United States. In: Jeljaszewicz U (ed) The Staphylococci, vol Suppl. 14. Gustav Fischer Verlag, New York, pp 625–628
Novick RP (1993) Staphylococcus. In: Sonenhein A, Hoch A, Losich R (eds) Biochemistry, physiology and molecular genetics: Bacillus subtilis and other gram positive bacteria. American Society for Microbiology, Washington, pp 17–33
Malachowa N, DeLeo FR (2010) Mobile genetic elements of Staphylococcus aureus. Cell Mol Life Sci 67(18):3057–3071. doi:10.1007/s00018-010-0389-4
Lowy FD (2003) Antimicrobial resistance: the example of Staphylococcus aureus. J Clin Investig 111(9):1265–1273. doi:10.1172/JCI18535
Jeljaszewicz J, Mlynarczyk G, Mlynarczyk A (2000) Antibiotic resistance in Gram-positive cocci. Int J Antimicrob Agents 16(4):473–478
Chambers HF, Deleo FR (2009) Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol 7(9):629–641. doi:10.1038/nrmicro2200
Kernodle DS (2000) Mechanisms of resistance to β-lactam antibiotics. In: Fischetti VA, Novick RP, Ferretti JJ, Portnoy DA, Rood JI (eds) Gram-positive pathogens. American Society for Microbiology, Washington, DC, pp 609–620
Hiramatsu K, Hanaki H, Ino T, Yabuta K, Oguri T, Tenover FC (1997) Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J Antimicrob Chemother 40(1):135–136
Showsh SA, De Boever EH, Clewell DB (2001) Vancomycin resistance plasmid in Enterococcus faecalis that encodes sensitivity to a sex pheromone also produced by Staphylococcus aureus. Antimicrob Agents Chemother 45(7):2177–2178
Woodford N, Johnson AP, Morrison D, Speller DC (1995) Current perspectives on glycopeptide resistance. Clin Microbiol Rev 8(4):585–615
Quintiliani R Jr, Courvalin P (1996) Characterization of Tn1547, a composite transposon flanked by the IS16 and IS256-like elements, that confers vancomycin resistance in Enterococcus faecalis BM4281. Gene 172(1):1–8
Pantosti A, Sanchini A, Monaco M (2007) Mechanisms of antibiotic resistance in Staphylococcus aureus. Futur Microbiol 2(3):323–334. doi:10.2217/17460913.2.3.323
Argudin MA, Mendoza MC, Rodicio MR (2010) Food poisoning and Staphylococcus aureus enterotoxins. Toxins 2(7):1751–1773. doi:10.3390/toxins2071751
Altboum Z, Hertman I, Sarid S (1985) Penicillinase plasmid-linked genetic determinants for enterotoxins B and C1 production in Staphylococcus aureus. Infect Immun 47(2):514–521
Jackson MP, Iandolo JJ (1986) Cloning and expression of the exfoliative toxin B gene from Staphylococcus aureus. J Bacteriol 166(2):574–580
Bukowski M, Wladyka B, Dubin G (2010) Exfoliative toxins of Staphylococcus aureus. Toxins 2(5):1148–1165. doi:10.3390/toxins2051148
Yamaguchi T, Hayashi T, Takami H, Ohnishi M, Murata T, Nakayama K, Asakawa K, Ohara M, Komatsuzawa H, Sugai M (2001) Complete nucleotide sequence of a Staphylococcus aureus exfoliative toxin B plasmid and identification of a novel ADP-ribosyltransferase, EDIN-C. Infect Immun 69(12):7760–7771. doi:10.1128/IAI.69.12.7760-7771.2001
Needham C, Noble WC, Dyke KG (1995) The staphylococcal insertion sequence IS257 is active. Plasmid 34(3):198–205. doi:10.1006/plas.1995.0005
Rouch DA, Byrne ME, Kong YC, Skurray RA (1987) The aacA-aphD gentamicin and kanamycin resistance determinant of Tn4001 from Staphylococcus aureus: expression and nucleotide sequence analysis. J Gen Microbiol 133(11):3039–3052
Lyon BR, Gillespie MT, Skurray RA (1987) Detection and characterization of IS256, an insertion sequence in Staphylococcus aureus. J Gen Microbiol 133(11):3031–3038
Lindsay JA (2010) Genomic variation and evolution of Staphylococcus aureus. Int J Med Microbiol 300(2–3):98–103. doi:10.1016/j.ijmm.2009.08.013
Rowland SJ, Dyke KG (1989) Characterization of the staphylococcal beta-lactamase transposon Tn552. EMBO J 8(9):2761–2773
Gill SR, Fouts DE, Archer GL, Mongodin EF, Deboy RT, Ravel J, Paulsen IT, Kolonay JF, Brinkac L, Beanan M, Dodson RJ, Daugherty SC, Madupu R, Angiuoli SV, Durkin AS, Haft DH, Vamathevan J, Khouri H, Utterback T, Lee C, Dimitrov G, Jiang L, Qin H, Weidman J, Tran K, Kang K, Hance IR, Nelson KE, Fraser CM (2005) Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. J Bacteriol 187(7):2426–2438. doi:10.1128/JB.187.7.2426-2438.2005
Trees DL, Iandolo JJ (1988) Identification of a Staphylococcus aureus transposon (Tn4291) that carries the methicillin resistance gene(s). J Bacteriol 170(1):149–154
Guinane CM, Penades JR, Fitzgerald JR (2011) The role of horizontal gene transfer in Staphylococcus aureus host adaptation. Virulence 2(3):241–243
Novick RP (2003) Mobile genetic elements and bacterial toxinoses: the superantigen-encoding pathogenicity islands of Staphylococcus aureus. Plasmid 49(2):93–105
Xia G, Wolz C (2013) Phages of Staphylococcus aureus and their impact on host evolution. Infection, genetics and evolution. J Mol Epidemiol Evol Genet Infect Dis. doi:10.1016/j.meegid.2013.04.022
Deghorain M, Van Melderen L (2012) The Staphylococci phages family: an overview. Viruses 4(12):3316–3335
Christie GE, Dokland T (2012) Pirates of the Caudovirales. Virology 434(2):210–221. doi:10.1016/j.virol.2012.10.028
Rippon JE (1952) A new serological division of Staphylococcus aureus bacteriophages: group G. Nature 170(4320):287
Rippon JE (1956) The classification of bacteriophages lysing staphylococci. J Hyg 54(2):213–226
Ackermann HW (1975) Classification of the bacteriophages of Gram-positive cocci: Micrococcus, Staphylococcus, and Streptococcus. Pathologie-Biologie 23(3):247–253
Kwan T, Liu J, DuBow M, Gros P, Pelletier J (2005) The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages. Proc Natl Acad Sci USA 102(14):5174–5179. doi:10.1073/pnas.0501140102
Deghorain M, Bobay LM, Smeesters PR, Bousbata S, Vermeersch M, Perez-Morga D, Dreze PA, Rocha EP, Touchon M, Van Melderen L (2012) Characterization of novel phages isolated in coagulase-negative staphylococci reveals evolutionary relationships with Staphylococcus aureus phages. J Bacteriol 194(21):5829–5839. doi:10.1128/JB.01085-12
Goerke C, Pantucek R, Holtfreter S, Schulte B, Zink M, Grumann D, Broker BM, Doskar J, Wolz C (2009) Diversity of prophages in dominant Staphylococcus aureus clonal lineages. J Bacteriol 191(11):3462–3468. doi:10.1128/JB.01804-08
McCarthy AJ, van Wamel W, Vandendriessche S, Larsen J, Denis O, Garcia-Graells C, Uhlemann AC, Lowy FD, Skov R, Lindsay JA (2012) Staphylococcus aureus CC398 clade associated with human-to-human transmission. Appl Environ Microbiol 78(24):8845–8848. doi:10.1128/AEM.02398-12
Sumby P, Waldor MK (2003) Transcription of the toxin genes present within the Staphylococcal phage phiSa3ms is intimately linked with the phage’s life cycle. J Bacteriol 185(23):6841–6851
Wagner PL, Waldor MK (2002) Bacteriophage control of bacterial virulence. Infect Immun 70(8):3985–3993
Mir-Sanchis I, Martinez-Rubio R, Marti M, Chen J, Lasa I, Novick RP, Tormo-Mas MA, Penades JR (2012) Control of Staphylococcus aureus pathogenicity island excision. Mol Microbiol 85(5):833–845. doi:10.1111/j.1365-2958.2012.08145.x
Ram G, Chen J, Kumar K, Ross HF, Ubeda C, Damle PK, Lane KD, Penades JR, Christie GE, Novick RP (2012) Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism. Proc Natl Acad Sci USA 109(40):16300–16305. doi:10.1073/pnas.1204615109
Dearborn AD, Dokland T (2012) Mobilization of pathogenicity islands by Staphylococcus aureus strain Newman bacteriophages. Bacteriophage 2(2):70–78
Christie GE, Matthews AM, King DG, Lane KD, Olivarez NP, Tallent SM, Gill SR, Novick RP (2010) The complete genomes of Staphylococcus aureus bacteriophages 80 and 80alpha—implications for the specificity of SaPI mobilization. Virology 407(2):381–390. doi:10.1016/j.virol.2010.08.036
Subedi A, Ubeda C, Adhikari RP, Penades JR, Novick RP (2007) Sequence analysis reveals genetic exchanges and intraspecific spread of SaPI2, a pathogenicity island involved in menstrual toxic shock. Microbiology 153(Pt 10):3235–3245. doi:10.1099/mic.0.2007/006932-0
Novick RP, Subedi A (2007) The SaPIs: mobile pathogenicity islands of Staphylococcus. Chem Immunol Allergy 93:42–57. doi:10.1159/0000100857
Baba T, Bae T, Schneewind O, Takeuchi F, Hiramatsu K (2008) Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands. J Bacteriol 190(1):300–310. doi:10.1128/JB.01000-07
Diep BA, Gill SR, Chang RF, Phan TH, Chen JH, Davidson MG, Lin F, Lin J, Carleton HA, Mongodin EF, Sensabaugh GF, Perdreau-Remington F (2006) Complete genome sequence of USA300, an epidemic clone of community-acquired methicillin-resistant Staphylococcus aureus. Lancet 367(9512):731–739. doi:10.1016/S0140-6736(06)68231-7
Hacker J, Blum-Oehler G, Muhldorfer I, Tschape H (1997) Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution. Mol Microbiol 23(6):1089–1097
Maiques E, Ubeda C, Tormo MA, Ferrer MD, Lasa I, Novick RP, Penades JR (2007) Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer. J Bacteriol 189(15):5608–5616. doi:10.1128/JB.00619-07
Sato’o Y, Omoe K, Ono HK, Nakane A, Hu DL (2013) A novel comprehensive analysis method for Staphylococcus aureus pathogenicity islands. Microbiol Immunol 57(2):91–99. doi:10.1111/1348-0421.12007
Viana D, Blanco J, Tormo-Mas MA, Selva L, Guinane CM, Baselga R, Corpa J, Lasa I, Novick RP, Fitzgerald JR, Penades JR (2010) Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein. Mol Microbiol 77(6):1583–1594
Ubeda C, Barry P, Penades JR, Novick RP (2007) A pathogenicity island replicon in Staphylococcus aureus replicates as an unstable plasmid. Proc Natl Acad Sci USA 104(36):14182–14188. doi:10.1073/pnas.0705994104
Ubeda C, Tormo MA, Cucarella C, Trotonda P, Foster TJ, Lasa I, Penades JR (2003) Sip, an integrase protein with excision, circularization and integration activities, defines a new family of mobile Staphylococcus aureus pathogenicity islands. Mol Microbiol 49(1):193–210
Ubeda C, Maiques E, Barry P, Matthews A, Tormo MA, Lasa I, Novick RP, Penades JR (2008) SaPI mutations affecting replication and transfer and enabling autonomous replication in the absence of helper phage. Mol Microbiol 67(3):493–503. doi:10.1111/j.1365-2958.2007.06027.x
Ubeda C, Maiques E, Tormo MA, Campoy S, Lasa I, Barbe J, Novick RP, Penades JR (2007) SaPI operon I is required for SaPI packaging and is controlled by LexA. Mol Microbiol 65(1):41–50. doi:10.1111/j.1365-2958.2007.05758.x
Ubeda C, Olivarez NP, Barry P, Wang H, Kong X, Matthews A, Tallent SM, Christie GE, Novick RP (2009) Specificity of staphylococcal phage and SaPI DNA packaging as revealed by integrase and terminase mutations. Mol Microbiol 72(1):98–108
Tormo MA, Ferrer MD, Maiques E, Ubeda C, Selva L, Lasa I, Calvete JJ, Novick RP, Penades JR (2008) Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins. J Bacteriol 190(7):2434–2440. doi:10.1128/JB.01349-07
Tormo-Mas MA, Mir I, Shrestha A, Tallent SM, Campoy S, Lasa I, Barbe J, Novick RP, Christie GE, Penades JR (2010) Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands. Nature 465(7299):779–782. doi:10.1038/nature09065
Schelin J, Wallin-Carlquist N, Cohn MT, Lindqvist R, Barker GC, Radstrom P (2011) The formation of Staphylococcus aureus enterotoxin in food environments and advances in risk assessment. Virulence 2(6):580–592. doi:10.4161/viru.2.6.18122
Pinchuk IV, Beswick EJ, Reyes VE (2010) Staphylococcal enterotoxins. Toxins 2(8):2177–2197. doi:10.3390/toxins2082177
Ortega E, Abriouel H, Lucas R, Galvez A (2010) Multiple roles of Staphylococcus aureus enterotoxins: pathogenicity, superantigenic activity, and correlation to antibiotic resistance. Toxins 2(8):2117–2131. doi:10.3390/toxins2082117
Hennekinne JA, De Buyser ML, Dragacci S (2012) Staphylococcus aureus and its food poisoning toxins: characterization and outbreak investigation. FEMS Microbiol Rev 36(4):815–836. doi:10.1111/j.1574-6976.2011.00311.x
Wilson GJ, Seo KS, Cartwright RA, Connelley T, Chuang-Smith ON, Merriman JA, Guinane CM, Park JY, Bohach GA, Schlievert PM, Morrison WI, Fitzgerald JR (2011) A novel core genome-encoded superantigen contributes to lethality of community-associated MRSA necrotizing pneumonia. PLoS Pathog 7:e1002271
Letertre C, Perelle S, Dilasser F, Fach P (2003) Identification of a new putative enterotoxin SEU encoded by the egc cluster of Staphylococcus aureus. J Appl Microbiol 95(1):38–43
Jarraud S, Peyrat MA, Lim A, Tristan A, Bes M, Mougel C, Etienne J, Vandenesch F, Bonneville M, Lina G (2001) egc, a highly prevalent operon of enterotoxin gene, forms a putative nursery of superantigens in Staphylococcus aureus. J Immunol 166(1):669–677
Monday SR, Bohach GA (2001) Genes encoding staphylococcal enterotoxins G and I are linked and separated by DNA related to other staphylococcal enterotoxins. J Nat Toxins 10(1):1–8
Thomas DY, Jarraud S, Lemercier B, Cozon G, Echasserieau K, Etienne J, Gougeon ML, Lina G, Vandenesch F (2006) Staphylococcal enterotoxin-like toxins U2 and V, two new staphylococcal superantigens arising from recombination within the enterotoxin gene cluster. Infect Immun 74(8):4724–4734. doi:10.1128/IAI.00132-06
Thomas D, Chou S, Dauwalder O, Lina G (2007) Diversity in Staphylococcus aureus enterotoxins. Chem Immunol Allergy 93:24–41. doi:10.1159/0000100856
Hacker J, Carniel E (2001) Ecological fitness, genomic islands and bacterial pathogenicity. A Darwinian view of the evolution of microbes. EMBO Rep 2(5):376–381. doi:10.1093/embo-reports/kve097
Ochman H, Lerat E, Daubin V (2005) Examining bacterial species under the specter of gene transfer and exchange. Proc Natl Acad Sci USA 102(Suppl 1):6595–6599. doi:10.1073/pnas.0502035102
Hentschel U, Hacker J (2001) Pathogenicity islands: the tip of the iceberg. Microbes Infect 3(7):545–548
Dobrindt U, Hochhut B, Hentschel U, Hacker J (2004) Genomic islands in pathogenic and environmental microorganisms. Nat Rev Microbiol 2(5):414–424. doi:10.1038/nrmicro884
Ito T, Okuma K, Ma XX, Yuzawa H, Hiramatsu K (2003) Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC. Drug Resist Updates 6(1):41–52
Lina G, Bohach GA, Nair SP, Hiramatsu K, Jouvin-Marche E, Mariuzza R, International Nomenclature Committee for Staphylococcal S (2004) Standard nomenclature for the superantigens expressed by Staphylococcus. J Infect Dis 189(12):2334–2336. doi:10.1086/420852
Holden MT, Feil EJ, Lindsay JA, Peacock SJ, Day NP, Enright MC, Foster TJ, Moore CE, Hurst L, Atkin R, Barron A, Bason N, Bentley SD, Chillingworth C, Chillingworth T, Churcher C, Clark L, Corton C, Cronin A, Doggett J, Dowd L, Feltwell T, Hance Z, Harris B, Hauser H, Holroyd S, Jagels K, James KD, Lennard N, Line A, Mayes R, Moule S, Mungall K, Ormond D, Quail MA, Rabbinowitsch E, Rutherford K, Sanders M, Sharp S, Simmonds M, Stevens K, Whitehead S, Barrell BG, Spratt BG, Parkhill J (2004) Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci USA 101(26):9786–9791. doi:10.1073/pnas.0402521101
Tsuru T, Kobayashi I (2008) Multiple genome comparison within a bacterial species reveals a unit of evolution spanning two adjacent genes in a tandem paralog cluster. Mol Biol Evol 25(11):2457–2473. doi:10.1093/molbev/msn192
Schmidt H, Hensel M (2004) Pathogenicity islands in bacterial pathogenesis. Clin Microbiol Rev 17(1):14–56
Waldron DE, Lindsay JA (2006) Sau1: a novel lineage-specific type I restriction-modification system that blocks horizontal gene transfer into Staphylococcus aureus and between S. aureus isolates of different lineages. J Bacteriol 188(15):5578–5585. doi:10.1128/JB.00418-06
Juhas M, Crook DW, Dimopoulou ID, Lunter G, Harding RM, Ferguson DJ, Hood DW (2007) Novel type IV secretion system involved in propagation of genomic islands. J Bacteriol 189(3):761–771. doi:10.1128/JB.01327-06
Hooper SD, Berg OG (2002) Detection of genes with atypical nucleotide sequence in microbial genomes. J Mol Evol 54(3):365–375. doi:10.1007/s00239-001-0051-8
Karlin S (2001) Detecting anomalous gene clusters and pathogenicity islands in diverse bacterial genomes. Trends Microbiol 9(7):335–343
Lawrence JG, Ochman H (1998) Molecular archaeology of the Escherichia coli genome. Proc Natl Acad Sci USA 95(16):9413–9417
Severin A, Wu SW, Tabei K, Tomasz A (2005) High-level (beta)-lactam resistance and cell wall synthesis catalyzed by the mecA homologue of Staphylococcus sciuri introduced into Staphylococcus aureus. J Bacteriol 187(19):6651–6658. doi:10.1128/JB.187.19.6651-6658.2005
Chongtrakool P, Ito T, Ma XX, Kondo Y, Trakulsomboon S, Tiensasitorn C, Jamklang M, Chavalit T, Song JH, Hiramatsu K (2006) Staphylococcal cassette chromosome mec (SCCmec) typing of methicillin-resistant Staphylococcus aureus strains isolated in 11 Asian countries: a proposal for a new nomenclature for SCCmec elements. Antimicrob Agents Chemother 50(3):1001–1012. doi:10.1128/AAC.50.3.1001-1012.2006
de Lencastre H, Oliveira D, Tomasz A (2007) Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power. Curr Opin Microbiol 10(5):428–435. doi:10.1016/j.mib.2007.08.003
International Working Group on the Classification of Staphylococcal Cassette Chromosome E (2009) Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements. Antimicrob Agents Chemother 53(12):4961–4967. doi:10.1128/AAC.00579-09
Luong TT, Ouyang S, Bush K, Lee CY (2002) Type 1 capsule genes of Staphylococcus aureus are carried in a staphylococcal cassette chromosome genetic element. J Bacteriol 184(13):3623–3629
Baba T, Takeuchi F, Kuroda M, Yuzawa H, Aoki K, Oguchi A, Nagai Y, Iwama N, Asano K, Naimi T, Kuroda H, Cui L, Yamamoto K, Hiramatsu K (2002) Genome and virulence determinants of high virulence community-acquired MRSA. Lancet 359(9320):1819–1827
Fraser JD, Proft T (2008) The bacterial superantigen and superantigen-like proteins. Immunol Rev 225:226–243. doi:10.1111/j.1600-065X.2008.00681.x
Herold BC, Immergluck LC, Maranan MC, Lauderdale DS, Gaskin RE, Boyle-Vavra S, Leitch CD, Daum RS (1998) Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. JAMA 279(8):593–598
Johnson AP, Aucken HM, Cavendish S, Ganner M, Wale MC, Warner M, Livermore DM, Cookson BD, Participants UE (2001) Dominance of EMRSA-15 and -16 among MRSA causing nosocomial bacteraemia in the UK: analysis of isolates from the European Antimicrobial Resistance Surveillance System (EARSS). J Antimicrob Chemother 48(1):143–144
Dufour P, Gillet Y, Bes M, Lina G, Vandenesch F, Floret D, Etienne J, Richet H (2002) Community-acquired methicillin-resistant Staphylococcus aureus infections in France: emergence of a single clone that produces Panton-Valentine leukocidin. Clin Infect Dis 35(7):819–824. doi:10.1086/342576
Chiang YC, Liao WW, Fan CM, Pai WY, Chiou CS, Tsen HY (2008) PCR detection of Staphylococcal enterotoxins (SEs) N, O, P, Q, R, U, and survey of SE types in Staphylococcus aureus isolates from food-poisoning cases in Taiwan. Int J Food Microbiol 121(1):66–73. doi:10.1016/j.ijfoodmicro.2007.10.005
Makris G, Wright JD, Ingham E, Holland KT (2004) The hyaluronate lyase of Staphylococcus aureus—a virulence factor? Microbiology 150(Pt 6):2005–2013. doi:10.1099/mic.0.26942-0
Barrio MB, Rainard P, Prevost G (2006) LukM/LukF’-PV is the most active Staphylococcus aureus leukotoxin on bovine neutrophils. Microbes Infect 8(8):2068–2074. doi:10.1016/j.micinf.2006.03.004
Stec-Niemczyk J, Pustelny K, Kisielewska M, Bista M, Boulware KT, Stennicke HR, Thogersen IB, Daugherty PS, Enghild JJ, Baczynski K, Popowicz GM, Dubin A, Potempa J, Dubin G (2009) Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus. Biochem J 419(3):555–564. doi:10.1042/BJ20081351
Yamaguchi T, Nishifuji K, Sasaki M, Fudaba Y, Aepfelbacher M, Takata T, Ohara M, Komatsuzawa H, Amagai M, Sugai M (2002) Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B. Infect Immun 70(10):5835–5845
Highlander SK, Hulten KG, Qin X, Jiang H, Yerrapragada S, Mason EO Jr, Shang Y, Williams TM, Fortunov RM, Liu Y, Igboeli O, Petrosino J, Tirumalai M, Uzman A, Fox GE, Cardenas AM, Muzny DM, Hemphill L, Ding Y, Dugan S, Blyth PR, Buhay CJ, Dinh HH, Hawes AC, Holder M, Kovar CL, Lee SL, Liu W, Nazareth LV, Wang Q, Zhou J, Kaplan SL, Weinstock GM (2007) Subtlegenetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus. BMC Microbiol 7:99. doi:10.1186/1471-2180-7-99
Mehlin C, Headley CM, Klebanoff SJ (1999) An inflammatory polypeptide complex from Staphylococcus epidermidis: isolation and characterization. J Exp Med 189(6):907–918
Vuong C, Durr M, Carmody AB, Peschel A, Klebanoff SJ, Otto M (2004) Regulated expression of pathogen-associated molecular pattern molecules in Staphylococcus epidermidis: quorum-sensing determines pro-inflammatory capacity and production of phenol-soluble modulins. Cell Microbiol 6(8):753–759. doi:10.1111/j.1462-5822.2004.00401.x
Ito T, Katayama Y, Asada K, Mori N, Tsutsumimoto K, Tiensasitorn C, Hiramatsu K (2001) Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 45(5):1323–1336. doi:10.1128/AAC.45.5.1323-1336.2001
Ito T, Katayama Y, Hiramatsu K (1999) Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315. Antimicrob Agents Chemother 43(6):1449–1458
Ma XX, Ito T, Tiensasitorn C, Jamklang M, Chongtrakool P, Boyle-Vavra S, Daum RS, Hiramatsu K (2002) Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemother 46(4):1147–1152
Ma XX, Ito T, Chongtrakool P, Hiramatsu K (2006) Predominance of clones carrying Panton-Valentine leukocidin genes among methicillin-resistant Staphylococcus aureus strains isolated in Japanese hospitals from 1979 to 1985. J Clin Microbiol 44(12):4515–4527. doi:10.1128/JCM.00985-06
Milheirico C, Oliveira DC, de Lencastre H (2007) Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: ‘SCCmec IV multiplex’. J Antimicrob Chemother 60(1):42–48. doi:10.1093/jac/dkm112
Berglund C, Ito T, Ma XX, Ikeda M, Watanabe S, Soderquist B, Hiramatsu K (2009) Genetic diversity of methicillin-resistant Staphylococcus aureus carrying type IV SCCmec in Orebro County and the western region of Sweden. J Antimicrob Chemother 63(1):32–41. doi:10.1093/jac/dkn435
Kwon NH, Park KT, Moon JS, Jung WK, Kim SH, Kim JM, Hong SK, Koo HC, Joo YS, Park YH (2005) Staphylococcal cassette chromosome mec (SCCmec) characterization and molecular analysis for methicillin-resistant Staphylococcus aureus and novel SCCmec subtype IVg isolated from bovine milk in Korea. J Antimicrob Chemother 56(4):624–632. doi:10.1093/jac/dki306
Ito T, Ma XX, Takeuchi F, Okuma K, Yuzawa H, Hiramatsu K (2004) Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC. Antimicrob Agents Chemother 48(7):2637–2651. doi:10.1128/AAC.48.7.2637-2651.2004
Berglund C, Ito T, Ikeda M, Ma XX, Soderquist B, Hiramatsu K (2008) Novel type of staphylococcal cassette chromosome mec in a methicillin-resistant Staphylococcus aureus strain isolated in Sweden. Antimicrob Agents Chemother 52(10):3512–3516. doi:10.1128/AAC.00087-08
Zhang K, McClure JA, Elsayed S, Conly JM (2009) Novel staphylococcal cassette chromosome mec type, tentatively designated type VIII, harboring class A mec and type 4 ccr gene complexes in a Canadian epidemic strain of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 53(2):531–540. doi:10.1128/AAC.01118-08
Li S, Skov RL, Han X, Larsen AR, Larsen J, Sorum M, Wulf M, Voss A, Hiramatsu K, Ito T (2011) Novel types of staphylococcal cassette chromosome mec elements identified in clonal complex 398 methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemother 55(6):3046–3050. doi:10.1128/AAC.01475-10
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Financial Support from Specific University Research (MSMT No. 20/2013).
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Alibayov, B., Baba-Moussa, L., Sina, H. et al. Staphylococcus aureus mobile genetic elements. Mol Biol Rep 41, 5005–5018 (2014). https://doi.org/10.1007/s11033-014-3367-3
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DOI: https://doi.org/10.1007/s11033-014-3367-3