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Immune-related chemotactic factors were found in acute coronary syndromes by bioinformatics

Molecular Biology Reports volume 41, pages 4389–4395 (2014)Cite this article

Abstract

DNA microarray data for thrombus-related leukocyte from patients with acute coronary syndrome (ACS) was analyzed to acquire key genes associated with ACS. Microarray data set GSE19339, including four ACS patients’ samples and four normal samples, were downloaded from Gene Expression Omnibus database. Raw data was pre-processed and differentially expressed genes (DEGs) were identified by Affy packages of R. The interaction network was established with STRING. DrugBank was retrieved to obtain relevant small molecules. A total of 487 differentially expressed genes were identified as DEGs between normal and disease samples. Among which, ten up-regulated genes belonging to chemokine family (CCL2, CCR1, CXCL3, CXCL2, CCL8, CXCL11, CCL7, IL10, CCL22 and CCL20) were related to inflammatory response. In addition, two inhibitors of CCL2 (L-Mimosine) were retrieved from the DrugBank database. Considering the roles of inflammatory response in the progression of ACS and the functions of the ten up-regulated genes, we speculated that these genes might be related to ACS. Moreover, the inhibitors could provide guidelines for future drug design acting on these genes.

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Affiliations

  1. Department of Special Needs Medical Branch, Shanghai Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Putuo District, Shanghai, 200065, China

    Lei Zhang & Hao Wang

  2. Department of Geriatrics, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China

    Jian Li

  3. Department of Hematology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China

    Aibin Liang

  4. Department of Cardiology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China

    Yang Liu

  5. Longhua Hospital Affiliated to Shanghai Traditional Chinese Medicine University, Shanghai, 200032, China

    Bing Deng

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  1. Lei Zhang
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  2. Jian Li
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  3. Aibin Liang
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  4. Yang Liu
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  5. Bing Deng
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Correspondence to Lei Zhang.

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Zhang, L., Li, J., Liang, A. et al. Immune-related chemotactic factors were found in acute coronary syndromes by bioinformatics. Mol Biol Rep 41, 4389–4395 (2014). https://doi.org/10.1007/s11033-014-3310-7

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  • DOI: https://doi.org/10.1007/s11033-014-3310-7

Keywords

  • Acute coronary syndrome
  • Differentially expressed gene
  • Functional enrichment analysis
  • Pathway analysis
  • Small molecule drug