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Polymorphisms of methylenetetrahydrofolate reductase and glutathione S-transferase are not associated with the risk of papillary thyroid cancer in Korean population

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Abstract

Korea has the highest incidence of thyroid cancer of any nation. We conducted a population-based, case–control study of the association between the risk of papillary thyroid cancer (PTC) in the Korean population and polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T, glutathione S-transferase class mu (GSTM1), and glutathione S-transferase class theta (GSTT1). The study subjects consisted of 2,194 newly diagnosed PTC cases and 1,669 population-based healthy controls. Odds ratios adjusted by age, sex, body mass index, smoking, drinking, serum thyroid-stimulating hormone level, family history of thyroid cancer, and previous history of thyroid disease, with 95 % confidence intervals, were estimated using logistic regression analysis. The frequencies of MTHFR 677TT genotypes, and null genotypes of GSTM1 and GSTT1 were 19.2, 56.8, and 51.4 % among PTC cases and 17.4, 54.1, and 50.6 % among the controls, respectively. No significant associations between PTC and TT genotypes of MTHFR C677T, null genotypes of GSTM1 and GSTT1, or double-null (GSTM1-GSTT1) genotypes were found. These findings suggest that polymorphisms of the MTHFR C677T, GSTM1 and GSTT1 genotypes do not contribute to the development of PTC susceptibility in the Korean population.

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None of the authors have any potential conflicts of interest associated with this research.

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Authors and Affiliations

  1. Department of Preventive Medicine, Chonnam National University Medical School, 160 Baekseok-ro, Dong-gu, Gwangju, 501-746, South Korea

    Sun-Seog Kweon & Min-Ho Shin

  2. Center for Creative Biomedical Scientists, Chonnam National University, 160 Baekseok-ro, Dong-gu, Gwangju, 501-746, South Korea

    Hee-Nam Kim

  3. Department of Laboratory Medicine, Chonnam National University Medical School, 160 Baekseok-ro, Dong-gu, Gwangju, 501-746, South Korea

    Soo-Hyun Kim

  4. Department of Internal Medicine, Chonnam National University Medical School, 160 Baekseok-ro, Dong-gu, Gwangju, 501-746, South Korea

    Ho-Cheol Kang

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  1. Sun-Seog Kweon
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  2. Min-Ho Shin
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  3. Hee-Nam Kim
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  4. Soo-Hyun Kim
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  5. Ho-Cheol Kang
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Correspondence to Ho-Cheol Kang.

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Kweon, SS., Shin, MH., Kim, HN. et al. Polymorphisms of methylenetetrahydrofolate reductase and glutathione S-transferase are not associated with the risk of papillary thyroid cancer in Korean population. Mol Biol Rep 41, 3793–3799 (2014). https://doi.org/10.1007/s11033-014-3245-z

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  • DOI: https://doi.org/10.1007/s11033-014-3245-z

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