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RETRACTED ARTICLE: Construction of pancreatic cancer double-factor regulatory network based on chip data on the transcriptional level

Molecular Biology Reports volume 41, pages 2875–2883 (2014)Cite this article

This article was retracted on 18 August 2015

Abstract

Transcription factor (TF) and microRNA (miRNA) have been discovered playing crucial roles in cancer development. However, the effect of TFs and miRNAs in pancreatic cancer pathogenesis remains vague. We attempted to reveal the possible mechanism of pancreatic cancer based on transcription level. Using GSE16515 datasets downloaded from gene expression omnibus database, we first identified the differentially expressed genes (DEGs) in pancreatic cancer by the limma package in R. Then the DEGs were mapped into DAVID to conduct the kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis. TFs and miRNAs that DEGs significantly enriched were identified by Fisher’s test, and then the pancreatic cancer double-factor regulatory network was constructed. In our study, total 1117 DEGs were identified and they significantly enriched in 4 KEGG pathways. A double-factor regulatory network was established, including 29 DEGs, 24 TFs, 25 miRNAs. In the network, LAMC2, BRIP1 and miR155 were identified which may be involved in pancreatic cancer development. In conclusion, the double-factor regulatory network was found to play an important role in pancreatic cancer progression and our results shed new light on the molecular mechanism of pancreatic cancer.

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Acknowledgments

This work was supported by the Fund of the Provincial Health Department of Heilongjiang Province (No. 2011-171), and we wish to express our warm thanks to Fenghe (Shanghai) Information Technology Co., Ltd. Their ideas and help gave a valuable added dimension to our research.

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Affiliations

  1. Department of Gastroenterology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37 Yiyuan Street, Nangang District, Harbin, 150001, Heilongjiang, China

    Li-Li Zhao, Tie-Fu Liu, Na Tao & Li-Wei Zhuang

  2. Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37 Yiyuan Street, Nangang District, Harbin, 150001, Heilongjiang, China

    Tong Zhang

  3. Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, No. 148 Baojian Street, Nangang District, Harbin, 150001, Heilongjiang, China

    Bing-Rong Liu

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  1. Li-Li Zhao
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  2. Tong Zhang
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  3. Bing-Rong Liu
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  4. Tie-Fu Liu
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Correspondence to Li-Wei Zhuang.

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The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Zhao, LL., Zhang, T., Liu, BR. et al. RETRACTED ARTICLE: Construction of pancreatic cancer double-factor regulatory network based on chip data on the transcriptional level. Mol Biol Rep 41, 2875–2883 (2014). https://doi.org/10.1007/s11033-014-3143-4

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  • DOI: https://doi.org/10.1007/s11033-014-3143-4

Keywords

  • Pancreatic cancer
  • Transcription factor (TF)
  • MicroRNA (miRNA)
  • Differentially expressed genes (DEGs)