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Association study of common variations of FBN1 gene and essential hypertension in Han Chinese population

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Abstract

Fibrillin-1 (FBN1) was reported to have impact on the physiological arterial stiffness and vascular remodeling with hypertension of recent years. In the previous study we reported the association of four functional single nucleotide polymorphisms (SNPs) of FBN1 gene and hypertension. Here, we further investigate the association of four tagging SNPs (tagSNPs) which covered remain genetic variation blocks of FBN1 gene with hypertension, blood pressure and efficacy of antihypertensive in a South Han Chinese population. A case–control study including 2,012 hypertension cases and 2,116 controls age- and sex-matched controls was conducted from a community-based population and four candidate tagSNPs of the FBN1 gene were genotyped. Association analysis by multiple logistic regression was conducted for allele, genotype and haplotype and hypertension, blood pressure trait and control status with antihypertensive. General linear model was applied to compare blood pressure levels between genotypes. The association of rs17361868 and hypertension was statistically significant and that was further observed in female, ≥55 years, non-smoking and non-drinking populations (P < 0.05). Significant association of rs668842, rs11635140 and hypertension were observed in <55 years population as well as the later in female and non-smoking populations respectively. Haplotype G-T constructed of rs668842 and rs11635140 was significantly associated with hypertension comparing to reference haplotype A-C (P = 0.022). Normally distributed square root of TGF-β1 (pg/ml) of hypertension cases (148.56 ± 66.46) was significantly higher than that of control (128.52 ± 65.11), P = 0.008. Furthermore, TGF-β1 was significantly correlated with SBP (r = 0.135, P = 0.018) and DBP (r = 0.154, P = 0.007) respectively whereas no statistical difference of blood pressure or TGF-β1 was observed between genotypes. Remarkably, rs17361868 were significantly associated with the status of blood pressure in the patients taking three of the antihypertensive drugs, Zhen Ju Jiang Ya tablets, Jiang Ya tablet and compound reserpine (P < 0.05). The present study provides further association evidence of FBN1 gene polymorphisms and hypertension, antihypertensive efficacy. Further replication of these results via association or prospective studies conducted in other populations is warranted.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Nos. 81273165, 30800947 and Grant No. 81072367), the Natural Science Foundation of Jiangsu Province (No. BK2011776), Science & Technology Program of Wuxi (Nos. ZD1011 and CSEW1N1112) and the Priority Academic Program for the Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 210029, China

    Jinfeng Chen, Jiahui Shen, Hairu Wang & Chong Shen

  2. Department of Cardiology, Affiliated Yixing People’s Hospital of Jiangsu University, People’s Hospital of Yixing City, Yixing, 214200, China

    Song Yang, Xianghai Zhao, Yanchun Chen, Yanni Ji, Wen Wang & Wei Zhou

  3. Department of Clinical Laboratory, Affiliated Yixing People’s Hospital of Jiangsu University, People’s Hospital of Yixing City, Yixing, 214200, China

    Xuecai Wang & Junming Tang

  4. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China

    Xiangfeng Lu & Shufeng Chen

  5. National Human Genome Center at Beijing, Beijing, 100176, China

    Laiyuan Wang & Hongfan Li

  6. Department of Neurology, Affiliated Yixing People’s Hospital of Jiangsu University, People’s Hospital of Yixing City, Yixing, 214200, China

    Yanping Zhao

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  1. Jinfeng Chen
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  2. Song Yang
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  3. Xianghai Zhao
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  4. Jiahui Shen
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  8. Wen Wang
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  9. Wei Zhou
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  10. Xuecai Wang
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  11. Junming Tang
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  12. Xiangfeng Lu
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  15. Hongfan Li
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  16. Chong Shen
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  17. Yanping Zhao
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Corresponding authors

Correspondence to Chong Shen or Yanping Zhao.

Additional information

Jinfeng Chen, Song Yang and Xianghai Zhao have equally contributed to this study.

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Chen, J., Yang, S., Zhao, X. et al. Association study of common variations of FBN1 gene and essential hypertension in Han Chinese population. Mol Biol Rep 41, 2257–2264 (2014). https://doi.org/10.1007/s11033-014-3078-9

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  • DOI: https://doi.org/10.1007/s11033-014-3078-9

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