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Grb10 is a dual regulator of receptor tyrosine kinase signaling

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Abstract

The adaptor protein Grb10 is a close homolog of Grb7 and Grb14. These proteins are characterized by an N-terminal proline-rich region, a Ras–GTPase binding domain, a PH domain, an SH2 domain and a BPS domain in between the PH and SH2 domains. Human Grb10 gene encodes three splice variants. These variants show differences in functionality. Grb10 associates with multiple proteins including tyrosine kinases in a tyrosine phosphorylation dependent or independent manner. Association with multiple proteins allows Grb10 to regulate different signaling pathways resulting in different biological consequences.

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Acknowledgments

We thank Professor Lars Rönnstrand for comments on manuscript. This research was funded by the Stiftelsen Olle Engkvist Byggmästare, Kungliga Fysiografiska Sällskapet i Lund, Ollie Elof Ericssons Stiftelse and Stiftelsen Lars Hiertas Minne.

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Authors and Affiliations

  1. Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Bagura Road, Barisal, Bangladesh

    Nuzhat N. Kabir & Julhash U. Kazi

  2. Translational Cancer Research, Department of Laboratory Medicine, Lund University, Medicon Village, Lund, Sweden

    Julhash U. Kazi

  3. Lund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden

    Julhash U. Kazi

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Correspondence to Julhash U. Kazi.

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Kabir, N.N., Kazi, J.U. Grb10 is a dual regulator of receptor tyrosine kinase signaling. Mol Biol Rep 41, 1985–1992 (2014). https://doi.org/10.1007/s11033-014-3046-4

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